Masayuki Hirose

Home blood pressure variability and risk of cardiovascular outcomes in elderly patients with non-valvular atrial fibrillation from the ANAFIE registry

Daisuke Yoshida, Keisuke Shinohara, Shota Ikeda, Masayuki Hirose et autres

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Ninjin’yoeito is associated with attenuation of postoperative decline in Prognostic Nutritional Index in patients with oral squamous cell carcinoma: a single-center, open-label, single-arm study

Hajime Suzuki, T Yoshimura, Haruka Amitani, Koshiro Tagawa et autres

Background Postoperative nutritional deterioration and immunosuppression are clinically important in patients undergoing surgery for oral squamous cell carcinoma (OSCC). The Prognostic Nutritional Index (PNI), calculated from serum albumin and total lymphocyte count, is associated with the prognosis of OSCC. Ninjin’yoeito (NYT), a …

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Long-term real-world effectiveness and safety of edoxaban in chronic thromboembolic pulmonary hypertension: a nationwide registry study

Kazuya Hosokawa, Masaki Kohei, Masayuki Hirose, Takumi Inami et autres

BACKGROUND: Long-term real-world outcomes of edoxaban in chronic thromboembolic pulmonary hypertension (CTEPH) remain incompletely characterized despite emerging evidence, including the KABUKI randomized trial. OBJECTIVES: To evaluate long-term effectiveness and safety of edoxaban in patients with CTEPH using a nationwide registry. METHODS: We …

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Upfront combination therapy with nintedanib and anti-inflammatory agents for progressive pulmonary fibrosis: a multicentre, single-arm phase 2 study (TOP-ILD)

Kazuya Tsubouchi, Masayuki Hirose, Reoto Takei, Tomoyuki Fujisawa et autres

Objective: Progressive pulmonary fibrosis (PPF) is a chronic interstitial lung disease (ILD) characterised by fibrotic progression and poor prognosis, with effective treatment strategies for previously untreated patients remaining unclear. This study evaluated the efficacy and safety of upfront combination therapy with anti-inflammatory …

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Biological impact of chemotherapy during treatment with EGFR tyrosine kinase inhibitors for non-small cell lung cancer positive for EGFR activating mutations

Eiji Iwama, Kazuko Sakai, Taishi Harada, Shintaro Kanda et autres

BACKGROUND: The aim of this study was to explore the biological impact of chemotherapy during epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment in individuals with non-small cell lung cancer (NSCLC). METHODS: Plasma and tumor tissue specimens were prospectively collected …

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Development and Validation of a Japanese Outcome Tool for Perceptual Assessment of Speech in Patients with Cleft Palate

Yuko Ogata, Masahiro Tezuka, Yuri Fujiwara, Yoshiko Takei et autres

INTRODUCTION: The lack of a standardized evaluation method for cleft palate (CP) speech makes it difficult to exchange information at the domestic and global levels. We aimed to develop and validate a Japanese outcome tool for the perceptual assessment of speech in …

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Relationship of dietary intake and eating behaviors with glycemic control and body weight under long-term treatment with dapagliflozin: an exploratory prospective study

Hisashi Yokomizo, Daiji Kawanami, Noriyuki Sonoda, Yasuhiro Ono et autres

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Biological Impact of Chemotherapy During Treatment with Egfr Tyrosine Kinase Inhibitors for Non-Small Cell Lung Cancer Positive for Egfr Activating Mutations

Eiji Iwama, Kazuko Sakai, Taishi Harada, Shintaro Kanda et autres

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Biological Impact of Chemotherapy During Treatment with Egfr Tyrosine Kinase Inhibitors for Non-Small Cell Lung Cancer Positive for Egfr Activating Mutations

Eiji Iwama, Kazuko Sakai, Taishi Harada, Shintaro Kanda et autres

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An exploratory cluster-randomized controlled trial on mindfulness yoga’s effectiveness in school-refusing children: reductions in SCAS-C physical injury fears and pulse rate

Suguru Kawazu, Marie Amitani, Hajime Suzuki, Haruka Amitani et autres

Introduction: School refusal is one of the serious problems with children's mental health, and various studies have examined its prevalence and factors among students. Although many studies suggested that anxiety and depression are deeply associated with school refusal, there is little agreement …

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Safety and efficacy of ripasudil eye drops in preterm infants with retinopathy of prematurity: phase 1/2, open label, single-arm trial

Mitsuru Arima, Hirosuke Inoue, Akiko Misumi, Shoko Tsukamoto et autres

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The effect of lavender aroma for anxiety disorder: a study protocol for a multicenter, double-masked, randomized, placebo-controlled clinical trial

Haruka Amitani, Ryusei Nishi, Kenichiro Sagiyama, Takamasa Fukumoto et autres

BACKGROUND: Anxiety disorder is the most prevalent psychiatric disorder. Benzodiazepines, which are often used for anxiety in patients with anxiety disorder, have various side effects. Lavender, one of the most commonly used essential oils in aromatherapy, has the potential to reduce benzodiazepine …

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