Turgay Yildirim

Effect of Poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA) Side-Chain Length on the Antimicrobial Activity of Tobramycin-POEGMA Conjugates against Pseudomonas aeruginosa

Turgay Yildirim, Annette S. Boese, Aghiad Bali, Marcus Koch et autres

Abstract Polymer conjugation of cationic antibiotics has emerged as a promising strategy to improve their pharmacological properties and enhance their performance in biofilm-associated infections. Herein, we investigate the effect of poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA) side-chain length on the physicochemical properties, …

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Chrysin-Loaded Micelles Regulate Cell Cycle and Induce Intrinsic and Extrinsic Apoptosis in Ovarian Cancer Cells

Serife Cakir, Ummugulsum Yildiz, Turgay Yildirim, Ömer Faruk Aydin

Effective intracellular delivery for ovarian cancer therapy remains a significant challenge. We present chrysin-loaded p(MMA-co-DMAEMA)-b-(OEGMA-co-DMA), PMOD-Chr, a nanoparticle platform precisely engineered via RAFT polymerization for advanced therapeutic delivery. This multi-functional platform features a hydrophobic p(MMA) core encapsulating chrysin (Chr), a pH-responsive p(DMAEMA) …

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A New Class of Polyion Complex Vesicles (PIC‐somes) to Improve Antimicrobial Activity of Tobramycin in Pseudomonas Aeruginosa Biofilms

Turgay Yildirim, Aghiad Bali, Marcus Koch, Pascal Paul et autres

Pseudomonas aeruginosa (PA) is a major healthcare concern due to its tolerance to antibiotics when enclosed in biofilms. Tobramycin (Tob), an effective cationic aminoglycoside antibiotic against planktonic PA, loses potency within PA biofilms due to hindered diffusion caused by interactions with anionic …

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Development of Polymer-Based Nanoparticles for the Reduction of Melittin Toxicity

Berrin Chatzi Memet, Eren Demirpolat, Turgay Yildirim, Ömer Faruk Aydin

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Mobbing Düzeyinin Demografik Özellikler Açısından İncelenmesi; Iğdır Sanayi Sitesi Örneği

Turgay Yildirim

Size-controlled clustering of iron oxide nanoparticles within fluorescent nanogels using LCST-driven self-assembly

Turgay Yildirim, Maria Pervez, Bo Li, Rachel K. O’Reilly

Size-controlled clustering of iron oxide nanoparticles (IONPs) within the fluorescent polymer nanogels was achieved using the lower critical solution temperature (LCST) driven self-assembly and cross-linking of grafted polymer on the IONPs. The grafted polymer was comprised of oligoethyleneglycol methacrylate (OEGMA) and a …

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Pharmapolymers in the 21st century: Synthetic polymers in drug delivery applications

Christoph Englert, Johannes C. Brendel, Tobias C. Majdanski, Turgay Yildirim et autres

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Polymersomes with Endosomal pH-Induced Vesicle-to-Micelle Morphology Transition and a Potential Application for Controlled Doxorubicin Delivery

Turgay Yildirim, Anja Traeger, Pelin Sungur, Stephanie Hoeppener et autres

In order to obtain a novel, pH responsive polymersome system, a series of pH responsive block copolymers were synthesized via the reversible addition-fragmentation chain transfer (RAFT) polymerization of 3,4-dihydro-2H-pyran (DHP) protected 2-hydroxyethyl methacrylate (HEMA) (2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl methacrylate (THP-HEMA)) and 2-(dimethylamino) ethyl methacrylate (DMAEMA) …

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Uptake of Retinoic Acid‐Modified PMMA Nanoparticles in LX‐2 and Liver Tissue by Raman Imaging and Intravital Microscopy

Turgay Yildirim, Christian Matthäus, Adrian Tibor Press, Stephanie M. Schubert et autres

A primary amino-functionalized methyl methacrylate-based statistical copolymer is covalently coupled with retinoic acid (RA) and a fluorescent dye (DY590) in order to investigate the feasibility of the RA containing polymeric nanoparticles for Raman imaging studies and to study the possible selectivity of …

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Dual pH and ultrasound responsive nanoparticles with pH triggered surface charge-conversional properties

Turgay Yildirim, Ilknur Yildirim, Roberto Yáñez Macías, Steffi Stumpf et autres

A novel ultrasound responsive nanoparticle system with tunable surface charge-conversional properties is presented.

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Thermosensitive spontaneous gradient copolymers with block- and gradient-like features

Roberto Yáñez Macías, Ihor Kulai, Jens Ulbrich, Turgay Yildirim et autres

Amphiphilic gradient copolymers with thermoresponsive properties were synthesized in one pot via RAFT copolymerization.

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Retinol initiated poly(lactide)s: stability upon polymerization and nanoparticle preparation

Ilknur Yildirim, Turgay Yildirim, Diana Kalden, Grit Festag et autres

The synthesis of retinol initiated polylactide (PLA) by ring opening polymerization (ROP) of l -lactide via in situ calcium alkoxide formation with all- trans -retinol and Ca[N(SiMe 3 ) 2 ] 2 (THF) 2 is described.

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