A. L. Hepburn

P044 The skin that told the story: from the incidental rash to acute respiratory failure

A. L. Hepburn

Abstract Introduction Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) characterised by skin rash and muscle weakness, and can be linked with interstitial lung disease (ILD). A severe, often amyopathic subtype is associated with the presence of anti-MDA5 antibodies and is linked …

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The role of intra‐operative void score during transurethral resection of prostate as a marker of efficacy: a feasibility study

Christian Robinson, A. L. Hepburn, Robin Turner, Amir Zarrabi

BACKGROUND: To assess the feasibility of a novel intra-operative void scoring technique. To determine if intra-operative void score (VS) could act as a marker for post-operative success following TURP. METHODS: Fifteen patients undergoing TURP were included in this single-centre feasibility study. All …

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The role of vitamin D testing and replacement in fibromyalgia: a systematic literature review

Shawn DP Ellis, Sam T. Kelly, Jonathan Shurlock, A. L. Hepburn

BACKGROUND: Fibromyalgia is a debilitating condition, characterized by extensive muscular pain and fatigue. Vitamin D is essential for overall health, with ubiquitous involvement in various inflammatory and pain pathways. Little is known about its role in fibromyalgia. We performed a systematic literature …

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080 Screening for diabetes and steroid-induced hyperglycaemia in patients with rheumatoid arthritis is done poorly

A. L. Hepburn, Nicola Pearson, Gail Darlington, Mike D Chard et autres

Background: Recent UK epidemiological research suggests a hazard ratio of 1.5 for diabetes in RA patients on prednisolone ≥5mg or daily. National guidelines produced by NICE, ARMA and BSR set clear standards for screening for diabetes and other cardiovascular risk factors in …

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Adult onset Still’s disease: rare but important cause of raised ferritin

Todd Leckie, Dominic Nee, A. L. Hepburn

Koperdanova and Cullis provide a concise and pragmatic approach to interpreting serum ferritin levels, which are commonly raised in a range of acute and chronic diseases.1 We would like to mention adult onset Still’s disease—a …

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Recurrent atraumatic metatarsal, rib and sacral insufficiency fractures in a woman with the antiphospholipid syndrome

Joseph Villiers, Munther A. Khamashta, A. L. Hepburn

Antiphospholipid syndrome (APS) is characterised by recurrent arterial and/or venous thromboses and recurrent late miscarriages in the presence of antiphospholipid antibodies, and can be a hugely debilitating disorder. While the commonest thrombotic manifestations of this condition such as deep vein thrombosis and …

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AB0461 The burden of behçet's disease in the south thames and, se coast regions – a regional review

L. Yalakki Jagadeesh, A. L. Hepburn, Rod Hughes, Brian P. Bourke et autres

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An Atraumatic Femoral Fracture in a Patient with Rheumatoid Arthritis and Osteoporosis Treated with Denosumab

Joseph Villiers, David W. Clark, Tony Jeswani, Scott P. Webster et autres

Osteoporosis is responsible for a significant burden both individually and socially, but is readily treated with antiresorptive agents and mineral supplementation. However, long-term usage of these agents, notably bisphosphonates, is rarely associated with atypical fractures. Denosumab is a monoclonal antibody that reduces …

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Temporal arteritis presenting with tongue necrosis

Anuttara Panchali Kumarasinghe, A. L. Hepburn, William J. Reuther, C.A. Pratt

Spontaneous glossodynia is uncommon and glossodynia progressing to necrosis is especially rare. Although the commonest cause of lingual necrosis is giant cell arteritis, only a few cases of a new diagnosis of giant cell arteritis, clinically presenting with isolated lingual necrosis, have …

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Don't forget the vasculitides

A. L. Hepburn

Clark and colleagues do not cite large vessel vasculitis as an important and readily treatable cause of a discrepancy in blood pressure recordings between limbs.1 For example, Takayasu’s arteritis is a rare granulomatous large vessel vasculitis and a …

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Scleroderma and related disorders: 223. Long Term Outcome in a Contemporary Systemic Sclerosis Cohort

Svetlana I. Nihtyanova, V. Ong, C Black, CP Denton et autres

Background: We have previously compared outcome in two groups of systemic sclerosis (SSc) patients with disease onset a decade apart and we reported data on 5 year survival and cumulative incidence of organ disease in a contemporary SSc cohort. The present study …

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Aspects of management

A. L. Hepburn, Tom Rider, K Jordan

In response to Cayley’s article,1 we would like to clarify some important aspects of the management of gout. In acute gout, we would recommend 0.5 mg of colchicine two to three times daily for three days, in accordance with published guidelines.2 More …

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