Takashi Konishi

Real‐Time Stress Visualization of Hydrogels Enabled by Supramolecularly Switched Stretch‐Induced Phase Separation

Sooyeon Noh, Akihide Sugawara, Naoaki Ishihara, Takashi Konishi et autres

The visualization of mechanical stress in soft materials is highly desirable; however, real-time optical readouts using conventional sensing approaches are problematic because mechanophore-based systems typically require strong threshold-type activation with slow recovery. Herein, we report supramolecular hydrogels that enable the continuous and …

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Synergistic Reinforcement of Composite Hydrogels via Dual Cross-Linking and Supramolecular Filler

Akihide Sugawara, Chao Luo, Kanji Yano, Yusei Fujiwara et autres

The weak mechanical properties of hydrogels limit their applicability in load-bearing environments. Here, tough composite hydrogels with dual supramolecular cross-linking via host–guest (HG) interactions were developed to enhance the mechanical properties. Primary HG cross-linking between β-cyclodextrin (β-CD) and adamantane (Ad) provided structural …

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Efficacy and continuability of 675 mg fremanezumab administration over 2 years

Shohei Yoshida, Noboru Imai, Masato Keicho, Jun Kamimura et autres

BACKGROUND: Real-world data on the long-term adherence to- and efficacy of fremanezumab 675 mg quarterly dosing remain scarce. Our study evaluated the efficacy of- and patient adherence to 675 mg fremanezumab for episodic migraine (EM) and chronic migraine (CM) over 2 years …

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Relation between the Water Content and Mechanical Properties of Hydrogels with Movable Cross-Links

Koki Nishida, Ryohei Ikura, Kenji Yamaoka, Osamu Urakawa et autres

To reveal the synergic effects of movable and reversible cross-links, we fabricated movable cross-linked hydrogels with hydrophobic acetylated cyclodextrins (CDs). The obtained hydrogels showed high toughness based on the broad range of relaxation times achieved by the high mobility of movable cross-links …

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Polymer crystallization process at high supercooling: Crystallization with nodular aggregation region near the glass transition

Takashi Konishi, Yoshihisa Miyamoto

Polymer crystallization has been treated as the formation mechanism of lamellae based on secondary nucleation. This treatment has well explained many experimental results especially at a low supercooling. On the other hand, it is also known that some experimental results cannot be …

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Headache-Related Characteristics of Biopsy-Confirmed Giant Cell Arteritis and the Relationship of Transmural Inflammation With Artery Tenderness and Chordal Thickening

Sho Shimohama, Noboru Imai, Takuya Tsubata, Kei Shinohara et autres

INTRODUCTION: Giant cell arteritis (GCA) is characterized by headaches, but few studies have examined the detailed characteristics of pathologically confirmed cases. We investigated the characteristics of GCA patients, particularly headache, and their correlation with pathological findings. METHODS: We retrospectively analyzed 26 patients …

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Neuroinflammation following anti-parkinsonian drugs in early Parkinson’s disease: a longitudinal PET study

Tatsuhiro Terada, Tomoyasu Bunai, Takanori Hashizume, Takashi Matsudaira et autres

Abstract The progression of neuroinflammation after anti-parkinsonian therapy on the Parkinson’s disease (PD) brain and in vivo evidence of the therapy purporting neuroprotection remain unclear. To elucidate this, we examined changes in microglial activation, nigrostriatal degeneration, and clinical symptoms longitudinally after dopamine …

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Phase transitions and dynamics in ionic liquid crystals confined in nanopores

Hiroki Nobori, Daisuke Fujimoto, Jun Yoshioka, Koji Fukao et autres

We investigate the phase-transition behavior of ionic liquid crystals, namely 1-methyl-3-alkylimidazolium tetrafluoroborate, [Cnmim]BF4, confined in cylindrical nanopores using differential scanning calorimetry, x-ray scattering, and dielectric relaxation spectroscopy. Here, n is the number of carbon atoms in the alkyl part of this ionic …

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Headache-related characteristics of biopsy-confirmed giant cell arteritis and the relationship of transmural inflammation with artery tenderness and chordal thickening

Sho Shimohama, Noboru Imai, Takuya Tsubata, Kei Shinohara et autres

Abstract Giant cell arteritis (GCA) is characterised by headache, but few studies have examined detailed characteristics in pathologically confirmed cases. We aimed to investigate the characteristics of GCA, particularly headache, and their correlation with pathologic findings. We retrospectively analysed 26 patients (median …

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Tough citric acid-modified cellulose-containing polymer composites with three components consisting of movable cross-links and hydrogen bonds

Junsu Park, Yuki Asaki, Yuki Fujiwara, Takuma Wada et autres

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Distribution of Oriented Lamellar Structures in Injection-Molded High-Density Polyethylene Visualized via the Small Angle X-ray Scattering-Computed Tomography Method

Yuki Watanabe, Hiroki Ogawa, Takashi Konishi, Shotaro Nishitsuji et autres

Using the SAXS-CT method, which observed the spatial distribution of nanometer-scale structures on a micrometer scale, we investigated the orientation distribution of the lamellar structure of injection-molded HDPE. We reconstructed CT images in the plane perpendicular ( X–Y ) and the plane …

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Hybridizing a Dual-Cross Network and a Linear Glassy Polymer for Dynamic Contributions to High Mechanical Toughness Based on Phase-Separated Structures

Yusaku Kawai, Junsu Park, Shunsuke Murayama, Ryohei Ikura et autres

Bulk copolymerization of alkyl acrylate and cyclodextrin (CD) host monomers forms a single movable cross network (SC), in which the CD units act as movable cross-linkers. Moreover, the bulk copolymerization of the CD monomer and main chain monomer in the presence of …

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