Adelya Gabdulkhakova

SAT-173-YI TAZ and YAP play an interdependent role in biliary development and adaptation to cholestasis

Adelya Gabdulkhakova, Yekaterina Krutsenko, Satdarshan P. Monga, Laura Molina

Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury

Adelya Gabdulkhakova, Yekaterina Krutsenko, Junjie Zhu, Silvia Liu et autres

BACKGROUND: We previously showed that loss of yes-associated protein 1 (YAP) in early liver development (YAPKO) leads to an Alagille syndrome-like phenotype, with failure of intrahepatic bile duct development, severe cholestasis, and chronic hepatocyte adaptations to reduce liver injury. TAZ, a paralog …

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In the Absence of YAP, TAZ Contributes to Hepatocyte Adaptation in Chronic Cholestasis in Females

Laura Molina, Adelya Gabdulkhakova, Junjie Zhu, Silvia Liu et autres

We previously demonstrated that loss of Yes‐associated protein 1 (YAP1) in early liver development (YAP1 KO) leads to an Alagille syndrome‐like phenotype with absence of intrahepatic bile ducts and severe cholestasis accompanied by chronic hepatocyte adaptations to reduce liver injury. We noticed …

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