John G. Logan

Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease

Ryan C. Chai, Mischa Lundberg, Bernard Freudenthal, James T. Smith et autres

Musculoskeletal diseases are a major health burden. Development of bone-active therapies has been hindered by limited understanding of the cells and genes that regulate the skeleton. We exploited the value of cross-species analysis and developed single-cell methodologies in skeletal tissues to define …

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457 | BREATH BIOMARKERS FOR PREDICTION OF CYTOKINE RELEASE SYNDROME IN PATIENTS RECEIVING CHIMERIC ANTIGEN RECEPTOR T‐CELL THERAPY

Tessa M. John, Amalia Z. Berna, Yuhong Liu, John G. Logan et autres

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Genome-wide screening reveals the genetic basis of mammalian embryonic eye development

Justine M. Chee, Louise Lanoue, Dave Clary, Kendall Higgins et autres

BACKGROUND: Microphthalmia, anophthalmia, and coloboma (MAC) spectrum disease encompasses a group of eye malformations which play a role in childhood visual impairment. Although the predominant cause of eye malformations is known to be heritable in nature, with 80% of cases displaying loss-of-function …

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Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

Michelle McDonald, Weng Hua Khoo, Pei Ying Ng, Ya Xiao et autres

In brief: This paper reports an alternative cell fate for multinucleated, bone-resorbing osteoclasts and shows that they may undergo fission into smaller osteomorphs. The findings challenge the current dogma that osteoclasts primarily differentiate from hematopoietic progenitor cells and are terminally differentiated cells …

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Publisher Correction: Accelerating functional gene discovery in osteoarthritis

Natalie C. Butterfield, Katherine F. Curry, Julia Steinberg, Hannah F. Dewhurst et autres

The original version of this Article contained private information in the Data Availability statement, which was used by reviewers to access Proteomics datasets. This information has now been removed from both the PDF and HTML versions of this article.

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Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease

Scott E. Youlten, John P. Kemp, John G. Logan, Elena J. Ghirardello et autres

Abstract Osteocytes are master regulators of the skeleton. We mapped the transcriptome of osteocytes from different skeletal sites, across age and sexes in mice to reveal genes and molecular programs that control this complex cellular-network. We define an osteocyte transcriptome signature of …

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Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

Michelle M. McDonald, Weng Hua Khoo, Pei Ying Ng, Ya Xiao et autres

(Cell 184, 1330–1347.e1–e13; March 4, 2021) As a result of an author oversight in the originally published version of this article, the name of an author, Alexander Corr, did not appear in the author list. This error has now been corrected in …

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

Michelle M. McDonald, Weng Hua Khoo, Pei Ying Ng, Ya Xiao et autres

Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/macrophage-derived precursors that are thought to undergo apoptosis once resorption is complete. Here, by intravital imaging, we reveal that RANKL-stimulated osteoclasts have an alternative cell fate in which they fission into …

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Accelerating functional gene discovery in osteoarthritis

Natalie C. Butterfield, Katherine F. Curry, Julia Steinberg, Hannah F. Dewhurst et autres

Osteoarthritis causes debilitating pain and disability, resulting in a considerable socioeconomic burden, yet no drugs are available that prevent disease onset or progression. Here, we develop, validate and use rapid-throughput imaging techniques to identify abnormal joint phenotypes in randomly selected mutant mice …

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Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density

Anna Swan, Christine Schütt, Jan Rozman, Maria del Mar Muñiz Moreno et autres

The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for BMD, a measure that is frequently altered in a range of bone …

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Slc38a10 is a novel regulator of osteoblastic bone formation

Andrea S. Pollard, Davide Komla Ebri, Penny C. Sparkes, Apostolos Gogakos et autres

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Functional validation of the osteoporosis GWAS candidate FUBP3 in knockout mice

Laura Watts, Bernard Freudenthal, Natalie C. Butterfield, Andrea S. Pollard et autres

Osteoporosis affects millions of people worldwide, resulting in an enormous healthcare burden and major socioeconomic costs.Bone mineral density (BMD) is a highly heritable quantitative trait and the major risk factor for fracture.We and others have identified noncoding single nucleotide polymorphisms that define …

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