Alex McCormack

Surviving Colonies of Pseudomonas aeruginosa Isolated In Vivo from Infected, Antibiotic-Treated Galleria mellonella Larvae Acquire an Antibiotic-Tolerant Phenotype

Alex McCormack, Joanne K. Hobbs, Paul R. Johnston, Peter John Coote

Background: The aim of this work was to induce the formation of antibiotic-tolerant and/or persister cells in vivo using antibiotic therapy on Galleria mellonella larvae infected with P. aeruginosa, isolate these surviving cells, and characterise their phenotype and genotype. Methods: Infected larvae …

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Combination Therapy with Ciprofloxacin and Pentamidine against Multidrug-Resistant Pseudomonas aeruginosa: Assessment of In Vitro and In Vivo Efficacy and the Role of Resistance–Nodulation–Division (RND) Efflux Pumps

Megan Fletcher, Alex McCormack, Benjamin J. Parcell, Peter John Coote

The aim of this work was to (i) evaluate the efficacy of a combination treatment of pentamidine with ciprofloxacin against Galleria mellonella larvae infected with an MDR strain of P. aeruginosa and (ii) determine if pentamidine acts as an efflux-pump inhibitor. Resistant …

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The reflections of a Lincoln graduate in a small council facing a big challenge

Alex McCormack

The COMPTEL project and Logica's involvement.

Alex McCormack, Neelum Bains, Carol Jenkins, Rodney Bruce Hall et autres