Maureece Day

Loss and gain of motor protein function cause microtubule bundle damage in Drosophila axons

Yu-Ting Liew, Milli Owens, David M.D. Bailey, William Cairns et autres

Neurodegeneration often starts by atrophy of the cable-like nerve fibers (axons) that wire nervous systems. Maintaining axons requires supply via motor-protein-driven transport along uninterrupted bundles of microtubules. Functional loss of motor proteins, but surprisingly also their hyperactivation, links to conditions of axonal …

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Impacts of mitochondrial dysfunction on axonal microtubule bundles as a potential mechanism of neurodegeneration

Scott Murray-Cors, Yu-Ting Liew, Maureece Day, William Cairns et autres

Mitochondrial dysfunction is an important cause for neurodegeneration, often associated with dyshomeostasis of reactive oxygen species, i.e., oxidative stress. However, apart from ATP production, mitochondria have many other functions the aberration of which may impact neurons in very different ways. Oxidative stress …

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Assessing impacts of mitochondrial dysfunction on axonal microtubule bundles as potential mechanism in neurodegeneration

Scott Murray-Cors, Yu-Ting Liew, Maureece Day, William Cairns et autres

Mitochondrial dysfunction is an important cause for neurodegeneration, often associated with dyshomeostasis of reactive oxygen species, i.e. oxidative stress. However, apart from ATP production, mitochondria have many other functions the aberration of which may impact neurons in very different ways. Oxidative stress …

gb (code pays fourni par la source)

Different mechanisms link gain and loss of kinesin functions to axonal degeneration

Yu-Ting Liew, David M. Bailey, William Cairns, Maureece Day et autres

Abstract Axons are the slender, often meter-long projections of neurons that form the biological cables wiring our bodies. Most of these delicate structures must survive for an organism’s lifetime, meaning up to a century in humans. Long-term maintenance and sustained functionality of …

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Different Mechanisms Link Gain and Loss of Kinesin Functions to Axonal Degeneration

Yu-Ting Liew, David M. Bailey, William Cairns, Maureece Day et autres

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Electronic journal usage and policy at UMIST

Maureece Day

Le nombre de titres electroniques acquis par l'UMIST (University of Manchester Institute of Science and Technology) n'a pas cesse d'augmenter depuis le debut des annees 1990, en meme temps que le nombre d'abonnements sous forme papier a considerablement decru. Les donnees d'utilisation …

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