Marc A. Frahm

CD4+CD8+ T Cells Represent a Significant Portion of the Anti-HIV T Cell Response to Acute HIV Infection

Joseph J. Eron, Ralph A. Picking, Guido Ferrari, Marc A. Frahm et autres

Previous studies have revealed that HIV infected individuals possess circulating CD4+CD8+ (DP) T-cells specific for HIV antigens. In the present study, we analyzed the proliferation and functional profile of circulating DP T-cells from 30 acutely HIV infected individuals and 10 chronically HIV …

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The Human Antibody Response to the Surface of Mycobacterium tuberculosis

Casey C. Perley, Marc A. Frahm, Eva M. Click, Karen M. Dobos et autres

BACKGROUND: Vaccine-induced human antibodies to surface components of Haemophilus influenzae and Streptococcus pneumonia are correlated with protection. Monoclonal antibodies to surface components of Mycobacterium tuberculosis are also protective in animal models. We have characterized human antibodies that bind to the surface of …

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Response to Comment on “CD4+CD8+ T Cells Represent a Significant Portion of the Anti-HIV T Cell Response to Acute HIV Infection”

Marc A. Frahm, Georgia D. Tomaras, Guido Ferrari

Previous studies reported that the double-positive T cell compartment contains HIV-specific responses ([1][1], [2][2]). In our study, we further investigated the characteristics of the CD4+CD8+ T cell responses and reported 1) the magnitude of the double-positive T cell contribution to the total

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CD4+CD8+ T Cells Represent a Significant Portion of the Anti-HIV T Cell Response to Acute HIV Infection

Marc A. Frahm, Ralph A. Picking, JoAnn Kuruc, Kara McGee et autres

Previous studies have revealed that HIV-infected individuals possess circulating CD4(+)CD8(+) double-positive (DP) T cells specific for HIV Ags. In the present study, we analyzed the proliferation and functional profile of circulating DP T cells from 30 acutely HIV-infected individuals and 10 chronically …

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The Immune Response to Acute HIV-1 Infection and the Effect of HAART and HLA Alleles on the Control of Viral Replication

Marc A. Frahm

A fraction of HIV-1 patients are able to successfully control the virus and avoid developing AIDS. It has become increasingly clear that variations in the immune response during the initial days of acute infection including the period of peak viral replication determine …

Discriminating between latent and active tuberculosis with multiple biomarker responses

Marc A. Frahm, Neela D. Goswami, Kouros Owzar, Emily J. Hecker et autres

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Multi-cytokine Profiles After Tuberculosis Antigen Stimulation: A Search For New Biomarkers For Latent And Active Tuberculosis

Marc A. Frahm, Neela D. Goswami, Kouros Owzar, Emily J. Hecker et autres

1,25-Dihydroxyvitamin D3 up-regulates the renal vitamin D receptor through indirect gene activation and receptor stabilization

Kevin D. Healy, Marc A. Frahm, Hector F. DeLuca

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