Birgitte Lygren

Hvordan kan norske kreftpasienter få økt tilgang til kliniske studier?

Signe Øien Fretland, Birgitte Lygren, Ravinder Singh, Line Bjørge et autres

Hvordan kan norske kreftpasienter få økt tilgang til kliniske studier?KRONIKK Signe Øien Fretland er cand.pharm.og leder NorTrials koordinerende enhet ved Oslo universitetssykehus.Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. Birgitte Lygren er ph.d. og Medical Manager innen onkologi og kliniske studier, …

2376eP CONNECT: Enhancing precision cancer medicine through public-private collaboration

Emiel A. M. Janssen, Jörg Dahle, Kristian Hveem, S Fretland et autres

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New therapeutic strategy targeting regulation of the SERCA2 complex protects from myocardial ischemia-reperfusion injury

Ana I. Calejo, Ellen Østensen, Magnus Aronsen, Birgitte Lygren et autres

Abstract 7 million people suffer every year from myocardial infarction. There is significant unmet medical need for cardioprotection during MI treatment. The beta-adrenergic receptor/cyclic AMP/protein kinase A (PKA) signalling pathway regulates heart rate and contractility. Activation of cAMP-dependent PKA causes phospholamban (PLB) …

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A national precision cancer medicine implementation initiative for Norway

Kjetil Taskén, Hege Elisabeth Giercksky Russnes, Eline Aas, Line Bjørge et autres

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A PKA-ezrin-connexin 43 signaling complex controls gap junction communication and thereby trophoblast cell fusion

Guillaume Pidoux, Pascale Gerbaud, Jim Dompierre, Birgitte Lygren et autres

Cell fusion occurs as part of the differentiation of some cell types, including myotubes in muscle and osteoclasts in remodeling bone. In the human placenta, mononuclear cytotrophoblasts in a human chorionic gonadotropin (hCG)-driven process fuse to form multinucleated syncytia that allow the …

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Molecular basis of cholera blood group dependence

Julie Elisabeth Heggelund, Ellen Haugen, Birgitte Lygren, Alexander Mackay Mackenzie et autres

Cholera is a serious diarrhoeal disease that claims hundreds of thousands of deaths every year.The disease is known to be strongly blood-group dependent, with blood group O individuals experiencing increased risk of severe symptoms, but the molecular basis of this blood-group dependence …

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Both El Tor and classical cholera toxin bind blood group determinants

Julie Elisabeth Heggelund, Espen Haugen, Birgitte Lygren, Alasdair M. Mackenzie et autres

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An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria

Christopher Kable Means, Birgitte Lygren, Lorene K. Langeberg, Ankur Jain et autres

A-kinase anchoring proteins (AKAPs) tether the cAMP-dependent protein kinase (PKA) to intracellular sites where they preferentially phosphorylate target substrates. Most AKAPs exhibit nanomolar affinity for the regulatory (RII) subunit of the type II PKA holoenzyme, whereas dual-specificity anchoring proteins also bind the …

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The adaptor protein EBP50 is important for localization of the protein kinase A–Ezrin complex in T-cells and the immunomodulating effect of cAMP

Anne Jorunn Stokka, Randi Mosenden, Anja Ruppelt, Birgitte Lygren et autres

We recently reported that the dual-specificity AKAP (A-kinaseanchoring protein) Ezrin targets type I PKA (protein kinase A) to the vicinity of the TCR (T-cell receptor) in T-cells and, together with PAG (phosphoprotein associated with glycosphingolipid-enriched membrane microdomains) and EBP50 [ERM (Ezrin/Radixin/Moesin)-binding phosphoprotein …

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Design of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling

Eirik A. Torheim, Elisabeth Jarnæss, Birgitte Lygren, Kjetil Taskén

We have reported previously the design of a RIAD (RI-anchoring disruptor) peptide that specifically displaces PKA (protein kinase A) type I from the AKAP (A-kinase-anchoring protein) ezrin, which is present in the immunological synapse of T-cells. This increases immune reactivity by reducing …

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Mechanisms for cardiac dysfunction in COPD and respiratory failure

Karl‐Otto Larsen, Birgitte Lygren, Ivar Sjaastad, K.A. Krobert et autres

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Dual Specificity A-kinase Anchoring Proteins (AKAPs) Contain an Additional Binding Region That Enhances Targeting of Protein Kinase A Type I

Elisabeth Jarnæss, Anja Ruppelt, Anne Jorunn Stokka, Birgitte Lygren et autres

A-kinase anchoring proteins (AKAPs) target protein kinase A (PKA) to a variety of subcellular locations. Conventional AKAPs contain a 14-18-amino acid sequence that forms an amphipathic helix that binds with high affinity to the regulatory (R) subunit of PKA type II. More …

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