Fulvio Ratto

Hollow resonators for photoacoustic and photothermal spectroscopy

Gualtiero Nunzi Conti, Gabriele Frigenti, Lucia Cavigli, Fulvio Ratto et autres

Microbubble Resonators (MBRs) made in silica capillaries and based on Whispering Gallery Modes combine ultra-high optical and good mechanical Q-factors, together with integrated microfluidics, providing an ideal platform for photoacoustic (PA) and photothermal (PT) absorption spectroscopy. In the PA configuration, the MBR …

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Hierarchical materials based on polydimethylsiloxane as tissue-like phantoms for AI-enhanced photoacoustic imaging

Lucia Cavigli, Fulvio Ratto, Sonia Centi, Francesca Rossi et autres

Hierarchical materials as tissue-like phantoms for photoacoustic imaging

Lucia Cavigli, Sonia Centi, Fulvio Ratto, Francesca Rossi et autres

We introduce a hierarchical manufacturing method for creating anatomical phantoms using water-in-elastomer micro-emulsions. This approach addresses the cost, ethical, and technical limitations of animal models, providing a reliable alternative for multimodal imaging and artificial intelligence development, particularly in photoacoustic imaging.

Antitumoral Efficacy of AuNRs‐Laden ECFCs In Vitro and In Vivo: Decoding the Heat and Rays Combo Treatment in Breast Cancer and Melanoma Cells

Cecilia Anceschi, Francesca Scavone, Paolo Armanetti, Luca Menichetti et autres

Radiotherapy remains a cornerstone in metastatic cancer treatment but is often hindered by tumor hypoxia and radioresistance. Gold nanorods (AuNRs) offer promise in enhancing radiotherapy through hyperthermia, yet their clinical impact is limited by poor tumor targeting. Building on the previous findings …

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2576 MiniADAM: from a lung-equivalent compressible material to a miniaturized breathing phantom for theranostic applications

Immacolata Vanore, Fulvio Ratto, Andrea Profili, L. Marrazzo et autres

A universal label for the detection of PCR amplicons based on gold nanorods

Claudia Borri, Fulvio Ratto, Lara Mitia Castronovo, Patrizia Bogani et autres

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Plasmonic Particles for Optical Phantoms of Blood Tissue

Fulvio Ratto, Sonia Centi, Francesca Rossi, Giada Magni et autres

The biomedical engineering field faces significant challenges in transitioning innovations from proof-of-concept to practical applications. Animal models often contribute to these hurdles due to high costs, ethical concerns, as well as technical limitations. The development of reliable, low-cost, and multipurpose phantoms to …

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Novel Photo-sensitive Materials for Microengineering and Energy Harvesting

Domenico Sagnelli, Ambra Vestri, Amalia D'Avino, Massimo Rippa et autres

International audience

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Photomobile Polymer–Piezoelectric Composite for Enhanced Actuation and Energy Generation

Domenico Sagnelli, Amalia D’Avino, Massimo Rippa, Ambra Vestri et autres

In this study, we present an innovative approach to increase the quantum yield and wavelength sensitivity of photomobile polymer (PMP) films based on azobenzene by doping the polymer matrix with noble metal nanoparticles. These doped PMP films showed faster and more significant …

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Thermometric absorption spectroscopy through active locking of microbubble resonators

Gabriele Frigenti, Daniele Farnesi, Guglielmo Vesco, Sonia Centi et autres

We implemented a Microbubble Resonator (MBRs) as an opto-thermal transducer to reconstruct the absorption spectrum of a nanoparticle suspension through its temperature increase. The experimental configuration features the MBR as both the vial containing the suspension and the optical transducer, allowing for …

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Gold nanorods for integration in hybrid devices for biomedical applications

Fulvio Ratto, Sonia Centi, Claudia Borri, Filippo Micheletti et autres

Plasmonic particles like gold nanorods have aroused interest as contrast agents and labels for applications in biomedical optics and photonic sensing. Here, we review our recent work on complementary use cases of gold nanorods: A concept of cellular vehiculation with tumor-tropic cells, …

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Microbubble Resonators for Photoacoustic Detection and Photothermal Spectroscopy

Gabriele Frigenti, Lucia Cavigli, Fulvio Ratto, Sonia Centi et autres

Optical microresonators based on Whispering Gallery Modes have been extensively investigated as unique tools for fundamental studies and as core components in several applications. Specifically, microbubbles resonators (MBR) made from glass capillaries combine high optical and mechanical Q-factors together with intrinsic microfluidics, …

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