María Concepción Gutiérrez‐Ruíz

Corrigendum to “Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress” [Toxicology 361–362 (2016) 39–48]

Luis E. Gómez-Quiroz, Daekwan Seo, Yun‐Han Lee, Mitsuteru Kitade et autres

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Growth differentiation factor 11 modulates metabolism, mitigating the pro-tumoral behavior provided by M2-like macrophages in hepatocellular carcinoma-derived cells

Alejandro Escobedo‐Calvario, Lisette Chávez-Rodríguez, Verónica Souza-Arroyo, Leticia Bucio et autres

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most aggressive tumors worldwide. Chronic inflammation contributes to tumor evolution, and the infiltration of tumor-associated macrophages (TAMs), also known as M2-like macrophages, is associated with the most aggressive behavior. Therefore, these macrophages provide the …

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Cholesterol and the gut-liver axis: unraveling their role in the onset and progression of metabolic-associated steatotic liver disease

Luis A. Rodríguez-Rojas, Leticia Bucio, Verónica Souza-Arroyo, María Concepción Gutiérrez‐Ruíz et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease worldwide. Its prevalence is increasing due to its close relationship with obesity, insulin resistance, and other metabolic disorders. In this context, the gut-liver axis has been identified as …

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Correction: Acute pancreatitis experimental models, advantages and disadvantages

Genaro J Rosales-Muñoz, Verónica Souza-Arroyo, Leticia Bucio, Roxana U. Miranda-Labra et autres

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Acute pancreatitis experimental models, advantages and disadvantages

Genaro J Rosales-Muñoz, Verónica Souza-Arroyo, Leticia Bucio, Roxana U. Miranda-Labra et autres

Acute pancreatitis represents a severe health problem, not only because of the number of people affected but also because of the severity of its clinical presentation that can eventually lead to the death of patients. The study of the disease is complex, …

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Fructose induces metabolic reprogramming in liver cancer cells, promoting aggressiveness and chemotherapy resistance

Lisette Chávez-Rodríguez, Alejandro Escobedo‐Calvario, Verena Jendrossek, Johann Matschke et autres

Aim: Fructose is a highly lipogenic compound related to the onset of steatosis, its progression to steatohepatitis, and the eventual initiation of hepatocellular carcinoma (HCC). One of the cancer hallmarks is the metabolic adaptation to the environmental sources; however, this characteristic could …

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The GDF11 represses the Stat3 signaling pathway, conferring metabolic, inflammatory, and oncogenic restrictions in cells derived from human hepatocellular carcinoma.

M. Belén Sánchez-Rodríguez, Monserrat Gerardo‐Ramírez, Arturo Simoni‐Nieves, María Concepción Gutiérrez‐Ruíz et autres

GDF11 has shown potential in displaying anti-tumor effects in cells derived from human HCC, but the molecular mechanisms that lead to this, as well as the early transcriptomic response of GDF11 in HCC, remain a mystery. To identify potential targets for therapeutic …

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Metabolic reprogramming induced by fructose promotes therapy´s failure in liver cancer cells in vitro and in vivo.

Lisette Chávez-Rodríguez, Oscar A. Escobedo Calvario, Johann Matschke, Verena Jendrossek et autres

Metabolic reprogramming is a hallmark of cancer cells. Fructose metabolism is decreased in liver cancer cells to counteract the oxidative environment induced by fructose. Ketohexokinase (KHK) A is overexpressed, and its switch confers advantages to cancer cells. The objective was to investigate …

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The Hepatic Effect of Sub-chronic Chronic Cadmium Exposure.

Jessica N. Jiménez-Fabián, Karina Martínez‐Flores, Leticia Bucio, Roxana U. Miranda-Labra et autres

MAFLD is an umbrella disease characterized by lipids storage. Epidemiological studies found that cadmium (Cd) exposure is related to the development of MAFLD. We're interested in evaluating the effect of Cd exposure on lipid accumulation in the liver. Eight-week-old CD-1 mice were …

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GDF11 downregulates FOXP3 in T-cell acute lymphoblastic leukemia-derived cells and associates with restraining aggressiveness

M. Belén Sánchez-Rodríguez, Roberto Lazzarini‐Lechuga, Verónica Souza-Arroyo, Leticia Bucio et autres

Background: Growth differentiation factor 11 (GDF11), a transforming growth factor-beta superfamily member, is a crucial protein involved in many differentiation processes in embryogenesis and morphogenesis, and it has been extensively characterized due to its capacity to target poorly differentiated cells, including transformed …

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HOTAIR Promotes the Hyperactivation of PI3K/Akt and Wnt/β-Catenin Signaling Pathways via PTEN Hypermethylation in Cervical Cancer

Samuel Trujano-Camacho, David Cantú de León, Eloy Andrés Pérez-Yépez, Carlos Contreras-Romero et autres

The mechanisms underlying the sustained activation of the PI3K/AKT and Wnt/β-catenin pathways mediated by HOTAIR in cervical cancer (CC) have not been extensively described. To address this knowledge gap in the literature, we explored the interactions between these pathways by driving HOTAIR …

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The ecto-enzyme CD38 modulates CD4T cell immunometabolic responses and participates in HIV pathogenesis

Fernando Díaz-Basilio, Moises Vergara‐Mendoza, Jessica Romero-Rodríguez, Sharik Hernández-Rizo et autres

Despite abundant evidence correlating T cell CD38 expression and HIV infection pathogenesis, its role as a CD4T cell immunometabolic regulator remains unclear. We find that CD38's extracellular glycohydrolase activity restricts metabolic reprogramming after T cell receptor (TCR)-engaging stimulation in Jurkat T CD4 …

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