Waleed M. Renno

A Protective Role of Hydrogen Sulfide Donor GYY4137 Through Activated Microglia-induced Anti-inflammatory Cytokines in the Spinal Cord of Diabetic Rats

A.M. Mousa, Muneera AlDhaen, Bedoor Qabazard, Waleed M. Renno et autres

The increasing significance of inflammation in the pathophysiology of diabetes and its complications, such as diabetic peripheral neuropathy, has generated significant interest in targeting inflammation for disease prevention and control. Hydrogen sulfide (H₂S) has emerged as a promising therapeutic candidate due to …

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Regeneration of Insulin-Producing β Cells, Reduction in Inflammation and Oxidation Stress, and Improvement in Lipid Profile in a Type 1 Diabetes Rat Model by Intraperitoneal Injection of the Growth Factors-Rich Catfish Skin-Derived Fraction-B: An Introductory Report

Jassim Mohammad Al‐Hassan, Waleed M. Renno, Sosamma Oommen, Divya Nair et autres

Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells. The regeneration of durable insulin-producing β-cells remains a critical challenge. This study investigated the regenerative potential of Fraction-B (FB), a catfish skin-derived preparation rich in growth factors, in a T1D …

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The Regenerating Effect of FB from a Catfish Skin (Arius Bilineatus) on Carbon Tetrachloride-Induced Hepatotoxicity in a Rat Model (Abstract ID: 161497)

Waleed M. Renno, Fatemah J. Alomiri, Jassim Mohammad Al‐Hassan

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FRACTION B FROM CATFISH SKIN SECRETIONS CAUSES RECOVERY OF DIABETIC REPRODUCTIVE COMPILATIONS BY MODULATING THE APOPTOSIS AND DNA OXIDATIVE DAMAGE PATHWAYS IN RATS

Waleed M. Renno, Jassim Mohammad Al‐Hassan

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c-Jun N-terminal Kinase Supports Autophagy in Testicular Ischemia but Triggers Apoptosis in Ischemia-Reperfusion Injury

Sarah R. Alotaibi, Waleed M. Renno, May Al‐Maghrebi

Oxidative stress triggered by testicular torsion and detorsion in young males could negatively impact future fertility. Using a rat animal model for testicular IRI (tIRI), we aim to study the induction of autophagy (ATG) during testicular ischemia and tIRI and the role …

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Serotonergic and Adrenergic Neuroreceptor Manipulation Ameliorates Core Symptoms of ADHD through Modulating Dopaminergic Receptors in Spontaneously Hypertensive Rats

Sampath Madhyastha, Rao Ms, Waleed M. Renno

The core symptoms of attention deficit hyperactivity disorder (ADHD) are due to the hypofunction of the brain's adrenergic (NE) and dopamine (DA) systems. Drugs that enhance DA and NE neurotransmission in the brain by blocking their transporters or receptors are the current …

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Neuroprotective Effects of a Hydrogen Sulfide Donor in Streptozotocin-Induced Diabetic Rats

Abdulaziz M. F. Shayea, Waleed M. Renno, Bedoor Qabazard, Willias Masocha

Diabetic neuropathy is an important long-term complication of diabetes. This study explored the hypothesis that hydrogen sulfide (H2S) ameliorates neuropathic pain by controlling antiapoptotic and pro-apoptotic processes. The effects of a slow-releasing H2S donor, GYY4137, on the expression of antiapoptotic and pro-apoptotic …

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Isolated Flexor Digitorum Profundus Injuries in Flexor Zone II of the Hand: A Report of Five Cases

Ahmed Fareed Alkandari, Abrar Alawadhi, Fatma A Alawadhi, Waleed M. Renno

Injuries of the hand's flexor tendons carry a poor prognosis, mainly if they are in zone II (also called 'the critical zone' or 'no man's land'). The superficial tendon in this zone ends by bifurcating and attaching to the sides of the …

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Neuroregeneration of injured peripheral nerve by fraction B of catfish epidermal secretions through the reversal of the apoptotic pathway and DNA damage

Taiba Abdullah AlArbeed, Waleed M. Renno, Jassim Mohammad Al‐Hassan

Introduction: Crush injuries occur from acute traumatic nerve compression resulting in different degrees of neural damage leading to permanent functional deficits. Recently, we have shown that administration of Fraction B (FB) derived from catfish epidermal secretions accelerates healing of damaged nerve in …

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The impact of heat therapy on neuromuscular function and muscle atrophy in diabetic rats

Abdullah T. AlSabagh, Rao Ms, Waleed M. Renno

Introduction: Diabetes Mellitus (DM) is the most common metabolic disease worldwide and is associated with many systemic complications. Muscle atrophy is one of the significant complications in DM patients, making routine tasks laborious as atrophy continues. It is known that heat stress …

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Catfish Fraction B preparation improves the testicular morphology and functions through modulating the apoptotic pathway in STZ‐induced diabetes rat model

Waleed M. Renno, Jassim M. AlHassan

Diabetes Mellitus (DM)‐induced reproductive dysfunctions and infertility in men are globally on the rise with the increased incidence of DM patients. Diabetes causes testicular damage leading to reproductive dysfunctions. Further, DM‐induced reproductive dysfunctions are multifactorial in etiology encompassing both central (neurogenic) and …

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Catfish Epidermal Preparation Accelerates Healing of Damaged Nerve in a Sciatic Nerve Crush Injury Rat Model

Waleed M. Renno, Mohammad Afzal, Bincy Maniyalil Paul, Divya Nair et autres

, Val) epidermal gel secretion (PCEGS) exhibit potent anti-inflammatory and healing properties as shown in our previous clinical trials for the healing of non-healing diabetic foot ulcers, chronic back pain, and some other neurological disorders. Here, we report for the first time …

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