Hidde R. Zuidhof

The m6A demethylase FTO promotes C/ EBPβ ‐ LIP translation to perform oncogenic functions in breast cancer cells

Hidde R. Zuidhof, CHRISTINE B. MÜLLER, Gertrud Kortman, René Wardenaar et autres

N6-methyladenosine (m6A) is a prevalent posttranscriptional mRNA modification involved in the regulation of transcript turnover, translation, and other aspects of RNA fate. The modification is mediated by multicomponent methyltransferase complexes (so-called writers) and is reversed through the action of the m6A-demethylases fat …

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Author response for "The m6A demethylase FTO promotes C/ EBPβ ‐ LIP translation to perform oncogenic functions in breast cancer cells"

Hidde R. Zuidhof, Christine Müller, Gertrud Kortman, René Wardenaar et autres

Author Reply to Peer Reviews of Oncogenic functions of the m6A demethylase FTO in breast cancer cells involving translational upregulation of C/EBPβ-LIP

Hidde R. Zuidhof, CHRISTINE B. MÜLLER, Gertrud Kortman, René Wardenaar et autres

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Oncogenic functions of the m6A demethylase FTO in breast cancer cells involving translational upregulation of C/EBPβ-LIP

Hidde R. Zuidhof, CHRISTINE B. MÜLLER, Gertrud Kortman, René Wardenaar et autres

Abstract N6-methyladenosine (m6A) is a prevalent posttranscriptional mRNA modification involved in the regulation of transcript turnover, translation, and other aspects of RNA fate. The modification is mediated by multicomponent methyltransferase complexes (so-called writers) and is reversed through the action of the m6A-demethylases …

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C/EBPβ-LIP mediated activation of the malate-aspartate shuttle sensitizes cells to glycolysis inhibition

Tobias Ackermann, Hidde R. Zuidhof, CHRISTINE B. MÜLLER, Gertrud Kortman et autres

Cancer cells use glycolysis for generation of metabolic intermediates and ATP needed for cell growth and proliferation. The transcription factor C/EBPβ-LIP stimulates glycolysis and mitochondrial respiration in cancer cells. We initially observed that high expression of C/EBPβ-LIP makes cells vulnerable to treatment …

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Data from Oncogenic and Tumor-Suppressive Functions of the RNA Demethylase FTO

Hidde R. Zuidhof, Cornelis F. Calkhoven

Abstract The epitranscriptome represents the more than 140 types of chemically varying and reversable RNA modifications affecting RNA fate. Among these, the most relevant for this review are the mRNA modifications N6-methyladenosine and N6,2′-O-dimethyladenosine. Epitranscriptomic mRNA biology involves RNA methyltransferases (so-called “writers”), …

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Supplementary Table from Oncogenic and Tumor-Suppressive Functions of the RNA Demethylase FTO

Hidde R. Zuidhof, Cornelis F. Calkhoven

Supplementary Table from Oncogenic and Tumor-Suppressive Functions of the RNA Demethylase FTO

Supplementary Table from Oncogenic and Tumor-Suppressive Functions of the RNA Demethylase FTO

Hidde R. Zuidhof, Cornelis F. Calkhoven

Supplementary Table from Oncogenic and Tumor-Suppressive Functions of the RNA Demethylase FTO

Data from Oncogenic and Tumor-Suppressive Functions of the RNA Demethylase FTO

Hidde R. Zuidhof, Cornelis F. Calkhoven

Abstract The epitranscriptome represents the more than 140 types of chemically varying and reversable RNA modifications affecting RNA fate. Among these, the most relevant for this review are the mRNA modifications N6-methyladenosine and N6,2′-O-dimethyladenosine. Epitranscriptomic mRNA biology involves RNA methyltransferases (so-called “writers”), …

A Case of Yellow Airway Secretions and Oral Fluid

Hidde R. Zuidhof, Martijn van Schelt, Jeanine M.L. Roodhart, Maarten J. ten Berg et autres

A 52-year-old woman with a history of radioembolisation and chemotherapy for colorectal liver metastases presented with severe coughing, dyspnea, and production of yellow sputum. She was treated for pneumonia with antibiotics and corticosteroids, but coughing persisted for several weeks. During bronchoscopy, yellow …

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Translational control of C/EBPβ isoform expression

Hidde R. Zuidhof

The widely expressed C/EBPβ transcription factor regulates various cellular processes such as differentiation, proliferation, migration, senescence and apoptosis to maintain tissue homeostasis. Three protein isoforms (LAP1, LAP2 and LIP) are translated from the single‐exon CEBPB‐mRNA through the usage of alternative translation initiation …

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Oncogenic and Tumor-Suppressive Functions of the RNA Demethylase FTO

Hidde R. Zuidhof, Cornelis F. Calkhoven

The epitranscriptome represents the more than 140 types of chemically varying and reversable RNA modifications affecting RNA fate. Among these, the most relevant for this review are the mRNA modifications N6-methyladenosine and N6,2'-O-dimethyladenosine. Epitranscriptomic mRNA biology involves RNA methyltransferases (so-called "writers"), RNA …

nl (code pays fourni par la source)