Virgínia M. F. Gonçalves

Influence of Surface Sealants and Chromogenic Dietary Agents on the Color Stability of Composite Resin Restorations: An In Vitro Study

Jorge Ferreira-Coelho, Maria do Carmo Vilas-Boas, Orlanda Torres, Virgínia M. F. Gonçalves et autres

Background: The influence of surface sealants on the color stability of composite resin restorations remains controversial. This in vitro study evaluated the effect of two surface sealants on the color stability of a nanohybrid composite resin exposed to staining beverages. Methods: Ninety …

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Separação enantiomérica e determinação da configuração absoluta da 3-clorometacatinona, e avaliação da sua toxicidade em D. magna

Ivan Langa, João António, Claudia Cipriano Ribeiro, Ana Maria Guimarães Carvalho et autres

Introdução: A catinona sintética 3-clorometacatinona (3-CMC) é atualmente uma das novas substâncias psicoativas (NSP) mais prevalentes, representando cerca de 46 % das NSP apreendidas na Europa em 2023 (EUDA, 2025). A 3-CMC é uma molécula quiral que, após consumo, pode sofrer metabolismo …

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Fluoroquinolonas: Otimização de um método cromatográfico e avaliação ecotoxicológica em Daphnia magna

Ana Rita Carvalho, Renata Vidal, Virgínia M. F. Gonçalves, Alexandra Maia et autres

Introdução: As fluoroquinolonas (FQs) como a ofloxacina (OFL) são antibióticos utilizados na medicina humana e na veterinária, tanto em contextos profiláticos como terapêuticos. Devido ao elevado consumo e excreção parcial na forma não metabolizada, persistem no meio aquático, sendo frequentemente detetados em …

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Enantioselective toxicity of 3,4-methylenedioxypyrovalerone in Daphnia magna: Assessment of morphophysiological, behavioural, biochemical and reproductive responses

Ariana Pérez‐Pereira, Ana Rita Carvalho, Pedro Alexandre Costa, Bruno B. Castro et autres

The enantioselective toxicity of 3,4-methylenedioxypyrovalerone (MDPV) remains unexplored in freshwater organisms. This study investigated the effects of MDPV racemate and its enantiomers in Daphnia magna using two approaches: ( i ) an 8-day sub-chronic assay focused on early development stages; and ( …

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Unveiling enantioselective mechanisms of toxicity of butylone in Daphnia magna

R Vidal, Ana Rita Carvalho, Juliana Faria, Joana Barbosa et autres

• ( S )-BTL and racemate increased LIP4 expression gene leading to reduced body size/growth. • BTL caused neurotoxic effects, including acetylcholinesterase activity inhibition. • BTL caused upregulation of genes involved in dopamine and serotonin synthesis. • Enantioselective morphophysiological effects and AAAD …

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Effect of Ageing on the Mechanical Properties of Dental Resin with and Without Bisphenol A

Lígia Lopes‐Rocha, Orlanda Torres, Joana Garcez, Ricardo J. C. Carbas et autres

(1) Background: The work aims to determine different chemical and mechanical properties with and without BPA dental resin–matrix composites under the same curing and testing conditions. (2) Methods: Disc-shaped specimens were prepared from six resin–matrix composites used in dentistry, three with BPA …

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Exploring Factors Associated with Health Status and Dietary Supplement Use Among Portuguese Adults: A Cross-Sectional Online Survey

Sandra Leal, Ana Sousa, Rui Valdiviesso, Inês Pádua et autres

Background/Objectives: Dietary supplements are associated with general well-being. However, there is a growing concern about health risks from unlabeled harmful substances, contaminants, or their interactions with conventional drugs. The use of dietary supplements should also be monitored in vulnerable groups. Hence, this …

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Fishroesomes show intrinsic anti-inflammatory bioactivity and ability as celecoxib carriers in vivo

Marta Guedes, Joana Vieira de Castro, Ana Cláudia Lima, Virgínia M. F. Gonçalves et autres

According to the World Health Organization (WHO), chronic inflammatory-related diseases represent the greatest threat to human health. Indeed, failure in the resolution of inflammation leads to serious pathological conditions, such as cardiovascular diseases, arthritis, cancer, diabetes, autoimmune diseases, and neurodegenerative disorders that …

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Evaluation of Echinacea purpurea Extracts as Immunostimulants: Impact on Macrophage Activation

Sara F. Vieira, Samuel M. Gonçalves, Virgínia M. F. Gonçalves, Maria Elizabeth Tiritan et autres

Abstract Echinacea purpurea has been traditionally used to strengthen the immune system. Therefore, herein, we investigated the potential of E. purpurea aqueous extracts (AEs) obtained from flowers (F), leaves (L), or roots (R) as an immune booster in human primary monocyte‐derived macrophages …

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Unveil the toxicity induced on early life stages of zebrafish (Danio rerio) exposed to 3,4-methylenedioxymethamphetamine (MDMA) and its enantiomers

Ondina Ribeiro, Luís Félix, Cláudia Ribeiro, Mónica Torres-Ruíz et autres

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Development of an Enantioselective Method by Liquid Chromatography to Monitor 3,4-Methylenedioxypyrovalerone in Culture Media from Ecotoxicity Assays

Ariana Pérez‐Pereira, Virgínia M. F. Gonçalves, Ana R. Ribeiro, Carla Fernandes et autres

3,4-Methylenedioxypyrovalerone (MDPV) is an emerging, chiral, new psychoactive substance belonging to the synthetic cathinones group that has been frequently detected in wastewater effluents and aquatic environments. However, the knowledge of its enantioselective occurrence and toxicity toward aquatic organisms is scarce. The aim …

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Amphetamine-like substances and synthetic cathinones in Portuguese wastewater influents: Enantiomeric profiling and role of suspended particulate matter

Ivan M. Langa, Nuno Ratola, Virgínia M. F. Gonçalves, Maria Elizabeth Tiritan et autres

Wastewater based epidemiology (WBE) has been used worldwide to estimate drug consumption routinely. Even though WBE provides valuable data to support legal and health interventions associated to drug use, monitoring studies in Portuguese wastewaters are scarce. Hence, this work aimed to estimate …

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