Xingzhu Yin

Associations between biological aging and the risk of endometriosis: Evidence from a large population-based prospective cohort study

Yang Chen, Li Chen, Xingzhu Yin, Biao Chen et autres

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Interleukin 33 Promotes Liver Sinusoidal Endothelial Cell Dysfunction and Hepatic Fibrosis in Diabetic Mice

Huimin Chen, Chao Gao, Mo Li, Xingzhu Yin et autres

BACKGRUOUND: Interleukin 33 (IL33) drives liver fibrosis, and individuals with type 2 diabetes mellitus are more likely advanced to liver fibrosis. However, the role of IL33 in diabetic liver fibrosis remains unclear, prompting our investigation. METHODS: We developed a diabetes model in …

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High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models

Li Chen, Bangfu Wu, Mo Li, Huimin Chen et autres

Accumulated senescent cells during the aging process are a key driver of functional decline and age-related disorders. Here, we identify ganoderic acid A (GAA) as a potent anti-senescent compound with low toxicity and favorable drug properties through high-content screening. GAA, a major …

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The Associations of Vitamin D Status and Lifestyle Behaviors with General Obesity and Metabolically Unhealthy Obesity in Chinese Children and Adolescents

Fangqu Liu, Li Yan, Chanhua Liang, Bingxuan Kong et autres

BACKGROUND: Vitamin D and lifestyle behaviors are closely related to children's health. However, current research on the combined influences of vitamin D and adherence to 24-Hour Movement Guidelines (24-HMG) on childhood obesity remains scarce. Our study aimed to examine individual and joint …

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Partial reduction of interleukin‐33 signaling improves senescence and renal injury in diabetic nephropathy

Li Chen, Chao Gao, Xingzhu Yin, Li Mo et autres

Diabetic nephropathy (DN) is a frequent and costly complication of diabetes with limited understandings of mechanisms and therapies. Emerging evidence points to the important roles of interleukin-33 (IL-33) in acute kidney injury, yet its contribution to DN is still unclear. We here …

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Chinese Healthy Eating Index (CHEI) and risk of diabetes in Chinese adults: a prospective cohort study

Zhuangyu Zhang, Fangqu Liu, Xingzhu Yin, Bangfu Wu et autres

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Biological ageing and the risks of all-cause and cause-specific mortality among people with diabetes: a prospective cohort study

Li Chen, Xingzhu Yin, Ying Zhao, Huimin Chen et autres

Background The aetiology of diabetes is complex with limited treatment strategies. Growing animal studies have shown that targeted antiageing can improve the outcomes of diabetes. However, population evidence is limited. This study aims to evaluate the associations of biological ageing with all-cause …

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