Jacob Epstein

APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics

Carla Cuní‐López, Jessica Root, Ying Hao, Niek Blomberg et autres

Lipid droplets are dynamic cellular organelles that store neutral lipids and coordinate metabolic and stress-response pathways. In the brain, lipid droplets in glial cells, including astrocytes, have been implicated in Alzheimer's disease, but how genetic risk factors influence their composition and turnover …

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Temporal proteomic and phosphoproteomic dynamics during neuronal differentiation in the reference iPSC line KOLF2.1J

Ying Hao, Ziyi Li, Erika Lara, Daniel M. Ramos et autres

Induced pluripotent stem cell (iPSC)-derived neurons are a powerful tool with which to investigate both neuronal development and neurodegenerative diseases. Here, we applied quantitative proteomic and phosphoproteomic analyses to profile the neuronal differentiation of the KOLF2.1J iPSC line, the first reference line …

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Author response: Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

Veronica H. Ryan, Sydney Lawton, Joel F. Reyes, James Hawrot et autres

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Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

Veronica H. Ryan, Sydney Lawton, Joel F. Reyes, James Hawrot et autres

TDP-43 mislocalization and pathology occurs across a range of neurodegenerative diseases, but the pathways that modulate TDP-43 in neurons are not well understood. We generated a Halo-TDP-43 knock-in human induced pluripotent stem cell (iPSC) line and performed a genome-wide CRISPR interference FACS-based …

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Author response: Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

Veronica H. Ryan, Sydney Lawton, Joel F. Reyes, James Hawrot et autres

TDP-43 mislocalization and pathology occurs across a range of neurodegenerative diseases, but the pathways that modulate TDP-43 in neurons are not well understood. We generated a Halo-TDP-43 knock-in iPSC line and performed a genome-wide CRISPR interference FACS-based screen to identify modifiers of …

Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

Veronica H. Ryan, Sydney Lawton, Joel F. Reyes, James Hawrot et autres

Abstract TDP-43 mislocalization and pathology occurs across a range of neurodegenerative diseases, but the pathways that modulate TDP-43 in neurons are not well understood. We generated a Halo-TDP-43 knock-in iPSC line and performed a genome-wide CRISPR interference FACS-based screen to identify modifiers …

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Large-scale HLA immunopeptidome and interactome profiling in microglia

Sydney Klaisner, Ying Hao, Alexandra Beilina, Jae Hyeon Park et autres

Microglia are immune cells of the brain and act as major antigen presenting cells. Antigen presentation involves the human leukocyte antigen (HLA) complex, which is implicated in genetic risk of multiple neurodegenerative diseases. How HLA affects the function of microglia in the …

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Temporal dynamics of proteome and phosphorproteome during neuronal differentiation in the reference KOLF2.1J iPSC line

Ying Hao, Ziyi Li, Erika Lara, Daniel M. Ramos et autres

Abstract Induced pluripotent stem cell (iPSC)-derived neurons have emerged as a powerful model to investigate both neuronal development and neurodegenerative diseases. Although transcriptomics and imaging have been applied to characterize neuronal development signatures, comprehensive datasets of protein and post-translational modifications (PTMs) are …

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Proteomic Analysis of Endemic Viral Infections in Neurons offers Insights into Neurodegenerative Diseases

Ziyi Li, Negin P. Martin, Jacob Epstein, Shih‐Heng Chen et autres

Endemic viral infections with low pathogenicity are often overlooked due to their mild symptoms, yet they can exert long-term effects on cellular function and contribute to disease pathogenesis. While viral infections have been implicated in neurodegenerative disorders, their impact on the neuronal …

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Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

Veronica H. Ryan, Sydney Lawton, Joel F. Reyes, James Hawrot et autres

TDP-43 mislocalization and pathology occurs across a range of neurodegenerative diseases, but the pathways that modulate TDP-43 in neurons are not well understood. We generated a Halo-TDP-43 knock-in human induced pluripotent stem cell (iPSC) line and performed a genome-wide CRISPR interference FACS-based …

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Rurality and Outcomes of Patients Undergoing Mechanical Thrombectomy for Acute Ischemic Stroke

Cassidy Lavin, Jacob Epstein, Huanwen Chen, Minahil Cheema et autres

Objective: To investigate differences in outcomes among patients with acute ischemic stroke from large vessel occlusion (AIS‐LVO) transferred from rural and urban hospitals to University of Maryland Medical Center (UMMC) for mechanical thrombectomy (MT). Methods: We identified patients with AIS‐LVO transferred to …

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Large-Scale HLA Immunopeptidome and Interactome Profiling in Microglia

Sydney Klaisner, Ying Hao, Alexandra Beilina, Jae Hyeon Park et autres

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