M. Taggi

L26/P-732 A family-building perspective in IVF: the contribution of each additional oocyte to cumulative live birth rate

E. Pittana, P. Petrone, A. Ruffa, F. Battista et autres

Abstract Study question Which is the contribution of each additional oocyte collected, regardless of the number of retrievals conducted, to the chance of 1 or 2 live-births (LBs)? Summary answer Each additional oocyte contributes to a 5.4%-increase in the odds of 1 …

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L26/P-893 Investigating technical variability in trophectoderm biopsy: implications for PGT data quality, re-biopsy and live-birth

V. Casciani, G.C. Cermisoni, F. Innocenti, M. Taggi et autres

Abstract Study question Which procedural and embryological factors of trophectoderm biopsy influence molecular data quality in PGT-A (median-absolute-pairwise-difference, MAPD-score), and do they associate with live-birth per euploid transfer? Summary answer Both day7-biopsy and biopsy operators were associated with higher MAPD-score. Only day7-biopsy …

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L26/P-153 Explainable AI reveals cytoplasmic dynamics and morphodynamic features during early development predictive of blastulation

A. Fantinato, L. Corso, M. Isernia, E. Kayar et autres

Abstract Study question Can explainable computer vision-based AI support transparent prediction of blastulation and understanding of preimplantation embryo development dynamics analysing the first 24hr post-ICSI? Summary answer Explainable AI identified predictive cytoplasmic dynamics at 0-5hr and 18-20hr post-ICSI, stressing the importance of …

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L26/P-873 From eggs to babies: outlining the competence of each single oocyte and the impact of intrinsic and extrinsic factors

P. Petrone, E. Pittana, A. Ruffa, F. Battista et autres

Abstract Study question Which intrinsic and extrinsic factors influenced the oocyte-to-baby rate across 11 years over an IVF clinic? Summary answer The overall oocyte-to-baby rate was 7.7%±14.2%, ranging between 13.3%±15.7% for women <35yr in absence of severe-male-factor and 0.7%±2.7% for women ≥42yr …

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L26/P-903 Morphometric consequences of blastocyst manipulations: size reduction and lower re-expansion after warming without impact on live-birth

S. Santopaolo, S Alfano, A. Solinto, F.M. Golia et autres

Abstract Study question What morphometric changes occur in blastocysts following biopsy and vitrification, and how do they influence live birth rate (LBR)? Summary answer Compared to blastocysts’ morphometric assessment before manipulations, trophectoderm biopsy induces measurable blastocyst size reduction, and vitrification with and …

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L26/P-188 Late bloomers or wasted costs? The cost-effectiveness of day7-blastocysts in ICSI–PGT-A cycles

D. Cimadomo, F. Mulas, C.S. Ottolini, Mauro Cozzolino et autres

Abstract Study question Is it cost-effective to include day7-blastocysts in ICSI cycles with PGT-A? Summary answer A routine use of day7-blastocysts is not cost-effective. Conversely, it is cost-effective in women 35-41yr and/or when <3 sibling day5/6-blastocysts are obtained. What is known already …

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L26/P-590 Treatment discontinuation in IVF: an in-depth characterization across different settings

F. Battista, V. Perone, G.G. Incognito, M. Taggi et autres

Abstract Study question What is the prevalence, timing and determinants of treatment discontinuation and non-conversion in IVF across different settings? Summary answer Treatment discontinuation is frequent and multifactorial throughout the IVF journey, increasing among repeated cycles (>3 cycles), influenced by patient prognosis, …

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L26/P-151 Exploring morphometric and morphodynamic profiles of rescued germinal vesicle (GV) oocytes: a pilot study in the clinical setting

M. Taggi, S. Pasku, G. Milazzo, F. Agate et autres

Abstract Study question Which morphometric and morphodynamic features are associated with germinal vesicle (GV) oocyte rescue to metaphase-II (rMII) stage and subsequent developmental competence to blastocyst? Summary answer Larger GV-oocyte size and faster GV breakdown (GVBD) timing are associated with higher rescue …

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L26/O-009 Human cumulus cell-derived miRNAs regulate pathways underlying oocyte maturation and developmental competence

G. Brazzale, G. Fiorentino, V. Merico, M. Taggi et autres

Abstract Study question Can miRNAs released from human cumulus cells (CCs) contribute to the acquisition of oocyte developmental competence and reflect preimplantation developmental regulatory mechanisms conserved in mammals? Summary answer Human and mouse CCs surrounding competent or incompetent oocytes release miRNAs targeting …

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L26/O-232 Reducing treatment discontinuation between first and second IVF attempts: the value of a multicycle approach

A. Ruffa, D. Cimadomo, P. Petrone, F. Battista et autres

Abstract Study question What factors are associated with treatment discontinuation between first and second IVF attempts? Summary answer The gradual introduction of DuoStim and oocyte donation programs decreased treatment discontinuation between first and second attempts from 57% in 2014 to 33% in …

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Cumulus cells secrete micro-vesicles carrying miRNAs: their role in the acquisition of mouse and human oocyte's developmental competence

Danilo Cimadomo, G. Fiorentino, F. Innocenti, V. Merico et autres

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