Jingzhe Guo

TipQuant : a robust algorithm for quantitative analysis of spatiotemporally dynamic activities in tip‐growing cells

Jingzhe Guo, Julian Le Gouic, Rémi Rosenthal, Ailing Zou et autres

Abstract Cell polarity, essential for cell development and function, relies on dynamic subcellular distribution of structural and signaling molecules. Tip growth, an extreme form of polar growth, involves unidirectional expansion at the apical region of cells and requires precise spatiotemporal coordination to …

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COG7 links Golgi integrity to stress signaling and senescence

María Fernanda Gómez-Méndez, Yahir Oseguera, Genesis Oseguera, Jingzhe Guo et autres

The mechanisms linking Golgi function to stress adaptation and senescence remain poorly understood. Here, we identify the conserved oligomeric Golgi (COG) subunit COG7 as a non-redundant determinant of Golgi integrity and stress adaptation in Arabidopsis thaliana. Functional disruption of COG7 reduces Golgi …

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Lithological identification for mixed carbonate and clay sediments employing principal component analysis of geophysical logging

Jingzhe Guo, Liang Wang, Ya Li, Yuxia Wang et autres

This study proposes a novel method for lithological identification to address the challenge of accurate classification in complex sedimentary successions. Leveraging principal component analysis, the methodology was developed using Ordovician data from the Western Ordos Basin, where the lithological assemblage predominantly comprises …

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Data from: TipQuant: A robust algorithm for quantitative analysis of spatiotemporally dynamic activities in tip-growing cells

Jingzhe Guo, Julian Le Gouic, Rémi Rosenthal, Ailing Zou et autres

Understanding the spatiotemporal dynamics of structural and signaling molecules is essential for elucidating the mechanisms and functions of cell polarity. However, manual quantification of these dynamics is extremely time-consuming, hindering progress in the field. Here, we present TipQuant, an automated analysis tool …

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Bimodal retrograde signaling disrupts a suppressor network and activates a key transcriptional activator to direct stress responses

Liping Zeng, Jingzhe Guo, Carlos Rodríguez, María Fernanda Gómez-Méndez et autres

SUMMARY Plastid‐to‐nucleus communication, crucial for regulating stress‐responsive gene expression, has long intrigued researchers. This study reveals how the plastidial metabolite 2‐C‐methyl‐D‐erythritol‐2,4‐cyclopyrophosphate (MEcPP) orchestrates transcriptional reprogramming by modulating the rapid stress response element (RSRE), a conserved regulatory hub in the plant general stress …

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An evolutionarily conserved metabolite inhibits biofilm formation in Escherichia coli K-12

Jingzhe Guo, Wilhelmina T Van De Ven, Aleksandra Skirycz, Venkatesh P. Thirumalaikumar et autres

Methylerythritol cyclodiphosphate (MEcPP) is an intermediate in the biosynthesis of isoprenoids in plant plastids and in bacteria, and acts as a stress signal in plants. Here, we show that MEcPP regulates biofilm formation in Escherichia coli K-12 MG1655. Increased MEcPP levels, triggered …

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Integrated Dual-Channel Retrograde Signaling Directs Stress Responses by Degrading the HAT1/TPL/IMPα-9 Suppressor Complex and Activating CAMTA3

Liping Zeng, Jingzhe Guo, Malathy Palayam, Carlos Rodríguez et autres

Abstract The intricate communication between plastids and the nucleus, shaping stress-responsive gene expression, has long intrigued researchers. This study combines genetics, biochemical analysis, cellular biology, and protein modeling to uncover how the plastidial metabolite MEcPP activates the stress-response regulatory hub known as …

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Activation of stress-response genes by retrograde signaling-mediated destabilization of nuclear importin IMPα-9 and its interactor TPR2

Liping Zeng, María Fernanda Gómez-Méndez, Jingzhe Guo, Jishan Jiang et autres

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A G-type lectin receptor kinase negatively regulates Arabidopsis immunity against root-knot nematodes

Dongmei Zhou, Damaris Godinez-Vidal, Jiangman He, Marcella Teixeira et autres

Root-knot nematodes (Meloidogyne spp., RKN) are responsible for extensive crop losses worldwide. During infection, they penetrate plant roots, migrate between plant cells, and establish feeding sites, known as giant cells, near the root vasculature. Previously, we found that nematode perception and early …

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A multichannel Ca2+ nanomodulator amplifies exogenous and endogenous calcium overload for efficient antitumor and antimetastasis therapy

Xiaoai Chen, Chang Xu, Peng Zhao, Yu Zhang et autres

Calcium overload–based antitumor therapy via disruption of Ca 2+ homeostasis has attracted significant attention, although the efficient elevation of calcium overload is extremely challenging. We designed an exogenous and endogenous Ca 2+ multichannel nanomodulator (Lipo CaO 2 –TA–Fe 3+ /PArg). The material …

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Constrained Nonlinear and Mixed Effects Integral Differential Equation Models for Dynamic Cell Polarity Signaling

Zhen Xiao, Nicolas Brunel, Chenwei Tian, Jingzhe Guo et autres

Polar cell growth is a process that couples the establishment of cell polarity with growth and is extremely important in the growth, development, and reproduction of eukaryotic organisms, such as pollen tube growth during plant fertilization and neuronal axon growth in animals. …

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CamelliA-based simultaneous imaging of Ca2+ dynamics in subcellular compartments

Jingzhe Guo, Jiangman He, Katayoon Dehesh, Xinping Cui et autres

As a universal second messenger, calcium (Ca2+) transmits specific cellular signals via a spatiotemporal signature generated from its extracellular source and internal stores. Our knowledge of the mechanisms underlying the generation of a Ca2+ signature is hampered by limited tools for simultaneously …

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