Quan Zhou

A lipoprotein-biomimetic nanoplatform for oncogenic KRAS mutation-specific lysosome-targeting protein degradation

Hang Yang, Xinyi Zhou, Jiafeng Wang, Chenyue Yang et autres

Lysosome-targeting protein degradation strategies have evolved to leverage lineage–specific receptors to improve selectivity, yet remain unable to distinguish malignant from normal cells within the same lineage. Since oncogenic mutations are the defining feature of malignant cells, we here develop KRAS-mutated (MT) tumor …

cn (code pays fourni par la source)

Development of pH-responsive ZIF-8-based multimetallic redox nanoreactors for ferroptosis-mediated cancer therapy

Wanmei Zhou, Zixin Wang, Chengdong Nie, Haiting Tian et autres

cn (code pays fourni par la source)

An innate immunity-reprogramming hydrogel nips postoperative adhesions in the bud via transforming pathological healing into physiological recovery

Yinqi Chen, Jiafeng Wang, Yechun Wang, Zimeng Liu et autres

cn (code pays fourni par la source)

Recent advances in cancer nanomedicine: From smart targeting to personalized therapeutics - pioneering a new era in precision oncology

Ayesha Younas, Shuanghu Wang, Muhammad Asad, Abdullah Al Mamun et autres

Cancer nanomedicine has evolved from the 1995 landmark approval of Doxil® into a programmable platform of precision oncology. The field now progresses along a coherent continuum that begins with passive enhanced permeability and retention (EPR)-mediated tumor accumulation, advances to active ligand-receptor targeting, …

cn, cz, pk (code pays fourni par la source)

Diaphragm Contraction Pressure Index: A New Forecasting Indicator for Weaning from Mechanical Ventilation

Peng Zhang, Haijiao Jiang, Zhizhong Li, Quan Zhou et autres

Purpose: Failure to wean from mechanical ventilation can lead to prolonged hospital stays, increased incidence of ventilator-associated pneumonia, and higher mortality rates. This study aimed to explore the effectiveness of the diaphragm contraction pressure index (DCPI) in predicting weaning outcomes in patients …

cn (code pays fourni par la source)

A skin-permeable polymer for non-invasive transdermal insulin delivery

Qiuyu Wei, Zhimin He, Zifan Li, Zhuxian Zhou et autres

Abstract Non-invasive skin permeation is widely used for convenient transdermal delivery of small-molecule therapeutics (less than 500 Da) with appropriate hydrophobicities 1 . However, it has long been deemed infeasible for large molecules—particularly polymers, proteins and peptides 2,3 —due to the formidable …

nz, cn, gb (code pays fourni par la source)

Aging-Directed Structural Evolution of In Situ Formed Polymeric Coacervates and Their Applications in Constructing Hierarchical Assemblies

Yongli Mu, Jiafeng Wang, Xiangrui Liu, Tianhua Zhou et autres

Liquid–liquid phase separation (LLPS) represents a metastable state that undergoes natural aging, ultimately evolving into either physiological arrested states or pathological amyloid fibrils. However, the influence of the aging process on the structural evolution of macromolecular condensates remains poorly understood. In this …

cn (code pays fourni par la source)

Nitric Oxide‐Enhanced Chitosan‐Based Nanoparticles for Dual‐Mode Photothermal and Photodynamic Therapy in Infected Wounds

Yueting Li, Shaojun Du, Xiaopeng Zhou, Jianfeng Wang et autres

Abstract Bacterial infections pose a significant challenge to global health, as conventional treatments frequently cause side effects and resistance. Phototherapy, encompassing photothermal therapy (PTT) and photodynamic therapy (PDT), emerges as a viable alternative, eradicating bacteria through heat and reactive oxygen species (ROS). …

cn (code pays fourni par la source)

Cholesterol sensing by the SCAP–FAM134B complex regulates ER-phagy and STING innate immunity

Boran Li, Dongheng Zhou, Xinyi Wang, Xiao Ming Jiang et autres

cn (code pays fourni par la source)

A two-dimensional liquid chromatography method with optimized pretreatment for detection of guanidine compounds in animal liver and kidney

Quan Zhou, Rong-Ju Yang, Yuqing Zhou, Jiali Jiang et autres

This study is centered on optimizing the derivatization reaction conditions and the protein precipitation reagent system for the detection of guanidine compounds (GCs) in animal liver and kidney. It introduces a two-dimensional liquid chromatography combined with ultraviolet detection (2D-LC-UV) method. The optimal …

cn (code pays fourni par la source)

In situ Electrochemical Transformation of MoO 2 /Mo 4 O 11 @Mo for High‐Capacity Aqueous Zinc‐Ion Batteries

Yinfeng Zhang, Xinlei Ma, Panpan Mi, Zhengbo Chen et autres

Abstract Taking advantage of the variable valence states of molybdenum, this work develops a MoO 2 /Mo 4 O 11 @Mo heterostructure as a highly efficient cathode, aiming to boost the electrochemical performance of aqueous zinc‐ion batteries (AZIBs). It is noteworthy that …

cn, Éthiopie (code pays fourni par la source)

An Activated Gasdermin Mimicking Polymer for Antitumor Immunity

Junjun Li, Yongli Mu, Yinqi Chen, Xuanhao Zhang et autres

Synthetic polymers with protein-like functions have the potential to revolutionize the way of modulating physiological processes. Pyroptosis, a form of gasdermin-driven programmed necrosis, is widely viewed as a promising strategy to ignite antitumor immunity. Yet, the intrinsic silence or absence of gasdermins …

cn, mo, us, nz (code pays fourni par la source)