Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study
Aung Ko Win, James G. Dowty, Jeanette C. Reece, Grant Lee et autres
BACKGROUND: Existing clinical practice guidelines for carriers of pathogenic variants of DNA mismatch repair genes (Lynch syndrome) are based on the mean age-specific cumulative risk (penetrance) of colorectal cancer for all carriers of pathogenic variants in the same gene. We aimed to …
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124 citations
The Lancet Oncology