Sutong Xiao

Enhancing Robustness of Constant Curvature Graph Convolutional Network with Lipschitz Regularization

Yang Shi, Jingchao Wang, Liangsi Lu, Haiying Huang et autres

Non-Euclidean spaces inherently enable high-fidelity embeddings for hierarchical and cyclical data due to their geometric properties. Existing approaches unify hyperbolic and spherical embeddings within the framework of constant curvature spaces. However, current methods for Lipschitz regularization remain limited to non-positive curvature geometries, …

cn, mo (code pays fourni par la source)

Photothermal‐Activable Artificial Macrophage With Amplified Systemic Antibacterial Responses to Combat Primary and Secondary Infection

Jiangge Li, Sutong Xiao, Shihuan Gao, Mao Wang et autres

The rapid evolution of antibiotic-resistant bacteria, particularly methicillin-resistant Staphylococcus aureus (MRSA), poses a critical threat to human healthcare, underscoring the need for antibiotic-free antibacterial strategies that achieve both effective pathogen eradication and sustained protection against reinfection. Here, inspired by the functions of …

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Sono‐Activated Artificial Vanadium Enzyme System for Efficient and Renewable Reactive Oxygen Nanobiocatalytic Therapies

Zihe Wu, Ling Li, Ting Wang, Sutong Xiao et autres

ABSTRACT Biocatalytic generation of reactive oxygen species (ROS) by artificial enzymes offers a promising strategy for treating diverse diseases, including pathogenic infections and malignancies. However, the sluggish ROS biocatalytic efficiency and unstable active sites have hindered their potential clinical translation. Here, inspired …

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Radio-Activable Gold-Single-Atom-Based Artificial Enzymes with Cascade Biocatalysis and Enhanced Radiosensitization to Prevent Metastasis and Recurrence in Malignancies

Yueting Zhu, Yu Min, Wei Geng, Zhigong Wei et autres

Radiotherapy is a cornerstone of oncological treatment and is frequently used in combination with chemotherapy or immunotherapy. However, its effectiveness is often limited by radioresistance and insufficient activation of systemic antitumor immunity. Overcoming these challenges necessitates the development of innovative radio-activable agents …

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Sonophoto-activable artificial cupreous peroxidases for controllable and redox-targeted ablation of primary and metastatic cancers

Ruiqian Guo, Sutong Xiao, Mao Wang, Wei Geng et autres

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Enzyme-reaction-system inspired nanobiocatalysts for bioadaptively eradicating primary and metastatic cancers

Sutong Xiao, Chuyi Han, Lang Ma, Wei Geng et autres

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Lattice‐Matched Iridium on Vanadium Nitride as Efficient Hydrogen Electrocatalyst

Yijuan Zheng, Zhenyu Xing, Sutong Xiao, Daoping Ye et autres

Abstract Iridium (Ir), with optimal hydrogen binding energy (HBE) and hydroxyl bonding energy (OHBE), is considered a promising platform for achieving bi‐directional hydrogen catalysis. However, traditional Ir‐based catalysts with multiple crystalline facets exhibit a gap between the apparent activity and theoretical value, …

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Sono-activable and biocatalytic 3D-printed scaffolds for intelligently sequential therapies in osteosarcoma eradication and defect regeneration

Xiao Rong, Sutong Xiao, Wei Geng, Bihui Zhu et autres

Abstract To mitigate the necessity for multiple invasive procedures in treating malignant osteosarcoma, an innovative therapeutic approach is imperative to achieve controllable tumor-killing effects and subsequent bone repair. Here, we propose the de novo design of sono-activable and biocatalytic nanoparticles-modified 3D-printed hydroxyapatite …

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Biocatalytic and Redox‐Regulated Nanoarchitectures for Precision Inflammation and Immune Homeostasis Modulation to Combat Rheumatoid Arthritis

Sutong Xiao, Songya Huang, Mao Wang, Ting Wang et autres

Abstract The chronic inflammatory milieu of rheumatoid arthritis (RA), marked by elevated reactive oxygen species (ROS), perpetually activated pro‐inflammatory macrophages (M1) and osteoclasts, and significant infiltration of pro‐inflammatory cytokines contributes to abnormal articular redox imbalance, severe synovitis, and progressive joint erosion. In …

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NADPH Oxidases‐Inspired Reactive Oxygen Biocatalysts with Electron‐Rich Pt Sites to Potently Amplify Immune Checkpoint Blockade Therapy (Adv. Mater. 3/2025)

Chuyi Han, Sutong Xiao, Zhenyu Xing, Xiaohui Xu et autres

Bioinspired Immunoregulatory Adjuvant In article number 2407644, Chong Cheng, Ling Ye, and co-workers introduce a bioinspired immunoregulatory adjuvant with electron-rich Pt sites and rapid electron transfer capability for superior reactive oxygen biocatalysis, which directly triggers endoplasmic reticulum stress, stimulates tumor-specific immune responses, …

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NADPH Oxidases‐Inspired Reactive Oxygen Biocatalysts with Electron‐Rich Pt Sites to Potently Amplify Immune Checkpoint Blockade Therapy

Chuyi Han, Sutong Xiao, Zhenyu Xing, Xiaohui Xu et autres

Abstract Clinical immune checkpoint blockade (ICB)‐based immunotherapy of malignant tumors only elicits durable responses in a minority of patients, primarily due to the highly immunosuppressive tumor microenvironment. Although inducing immunogenic cell death (ICD) through reactive oxygen biocatalyst represents an attractive therapeutic strategy …

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Infectious and Inflammatory Microenvironment Self‐Adaptive Artificial Peroxisomes with Synergetic Co‐Ru Pair Centers for Programmed Diabetic Ulcer Therapy

Yang Gao, Yuting Deng, Wei Geng, Sutong Xiao et autres

Complex microenvironments with bacterial infection, persistent inflammation, and impaired angiogenesis are the major challenges in chronic refractory diabetic ulcers. To address this challenge, a comprehensive strategy with highly effective and integrated antimicrobial, anti-inflammatory, and accelerated angiogenesis will offer a new pathway to …

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