Xiaomei Wan

ANP32B knockdown suppresses glioma malignant progression via the E2F1 pathway

Xiaomei Wan, Lilong Wu, Chengcheng Huang, Feilong Tang et autres

Background: Glioma is an aggressive primary brain malignancy with a poor prognosis. This study aimed to investigate the mechanism by which ANP32B drives glioma progression, focusing on its regulation of E2F1-mediated cell cycle and malignant phenotypes. Methods: Bioinformatics analysis was first performed …

Raloxifene inhibits the proliferation of pediatric acute myeloid leukemia by targeting the ANP32B gene and regulating C-MYC expression

Xiaomei Wan, YQ Zhong, Chengcheng Huang, Ying Ren

Acute myeloid leukemia (AML) is a severe and life-threatening malignant disease of the hematopoietic system. Our previous research found that ANP32B is regulated by super enhancers in pediatric AML and regulates the progression of AML by modulating histone H3K27ac. Using virtual screening …

Raloxifene inhibits the proliferation of pediatric acute myeloid leukemia by targeting the ANP32B gene and regulating C-MYC expression

Xiaomei Wan, Yu Zhong, Chengcheng Huang, Ying Ren

OBJECTIVE: Acute myeloid leukemia (AML) is a severe and life-threatening malignant disease of the hematopoietic system. Our previous research found that ANP32B is regulated by super enhancers in pediatric AML and regulates the progression of AML by modulating histone H3K27ac. Using virtual …

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Raloxifene inhibits the proliferation of pediatric acute myeloid leukemia by targeting the ANP32B gene and regulating C-MYC expression

Xiaomei Wan, YQ Zhong, Chengcheng Huang, Ying Ren

Acute myeloid leukemia (AML) is a severe and life-threatening malignant disease of the hematopoietic system. Our previous research found that ANP32B is regulated by super enhancers in pediatric AML and regulates the progression of AML by modulating histone H3K27ac. Using virtual screening …

Super-enhancer-driven ELOVL5 promotes T-ALL progression through the MYC-SERBP1 pathway

Shuqi Zhang, Wei Cheng, Tiandan Li, Zi-Mu Zhang et autres

Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, with T-cell acute lymphoblastic leukemia (T-ALL) accounting for 10–25 % of cases. We identified ELOVL5 as a super-enhancer–driven oncogene that is highly expressed in T-ALL and associated with poor overall survival. Through …

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Core transcriptional regulatory circuitry molecule ZNF217 promotes AML cell proliferation by up-regulating MYB

Bi‐Cheng Zhou, Fang Fang, Yongping Zhang, Zhiheng Li et autres

Leukemia is characterized by multiple rearrangements of signal transduction genes and overexpression of nonmutated genes, such as transcription factors (TFs) genes.Super-enhancers (SEs) are prevalent in human cancers and are associated with the accumulation of numerous core TFs.SEs drive the expression of core …

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Super enhancer related gene ANP32B promotes the proliferation of acute myeloid leukemia by enhancing MYC through histone acetylation

Xiaomei Wan, Jianwei Wang, Fang Fang, Yixin Hu et autres

BACKGROUND: Acute myeloid leukemia (AML) is a malignancy of the hematopoietic system, and childhood AML accounts for about 20% of pediatric leukemia. ANP32B, an important nuclear protein associated with proliferation, has been found to regulate hematopoiesis and CML leukemogenesis by inhibiting p53 …

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BRD4 PROTAC degrader MZ1 exhibits anti-B-cell acute lymphoblastic leukemia effects via targeting CCND3

Li Ma, Jianwei Wang, Yang Yang, Jun Lan Lu et autres

INTRODUCTION: B-cell acute lymphoblastic leukemia (B-ALL) is the most prevalent malignant tumor affecting children. While the majority of B-ALL patients (90%) experience successful recovery, early relapse cases of B-ALL continue to exhibit high mortality rates. MZ1, a novel inhibitor of Bromodomains and …

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BRD4 PROTAC degrader MZ1 exhibits anti-B-cell acute lymphoblastic leukemia effects via targeting CCND3

Li Ma, Jianwei Wang, Yang Yang, Jun Lü et autres

B-cell acute lymphoblastic leukemia (B-ALL) is the most prevalent malignant tumor affecting children. While the majority of B-ALL patients (90%) experience successful recovery, early relapse cases of B-ALL continue to exhibit high mortality rates. MZ1, a novel inhibitor of Bromodomains and extra-terminal …

The BRD4 Inhibitor dBET57 Exerts Anticancer Effects by Targeting Superenhancer-Related Genes in Neuroblastoma

Si-qi Jia, Ran Zhuo, Zi-Mu Zhang, Yang Yang et autres

Neuroblastoma (NB) is the most common solid tumor of the neural crest cell origin in children and has a poor prognosis in high-risk patients. The oncogene MYCN was found to be amplified at extremely high levels in approximately 20% of neuroblastoma cases. …

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BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes

Li Ma, Jianwei Wang, Yongping Zhang, Fang Fang et autres

Acute myeloid leukemia (AML) is a highly cancerous and aggressive hematologic disease with elevated levels of drug resistance and relapse resulting in high mortality. Recently, bromodomains and extra-terminal (BET) protein inhibitors have been extensively researched in hematological tumors as potential anticancer agents. …

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