Peng Xu

Brominated [15]Dehydrobenzoannulenes: Synthesis, Properties, and Applications

Yu Zuo, Huabi Xie, Chengye Yuan, Wenjie Chen et autres

Abstract Utilizing dehydrobenzoannulene (DBA) as a structural core, a brominated DBA molecular carbon material was concisely synthesized. To investigate the influence of substituents on the properties of such structures, four electron-donating methoxy groups were introduced onto the DBA ring. As a result, …

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Nitrogen-Doped Dehydrobenzoannulene as an Electron Acceptor Enabling Trace Epinephrine Analysis

Peng Xu, Huabi Xie, Yu Zuo, Ningwen Sun et autres

Herein, utilizing dehydrobenzoannulene and azadehydrobenzoannulene as the acceptor, three electron donor-acceptor architectures were divergently synthesized. Intriguingly, benefiting from the nitrogen-doped skeleton, the corresponding aza derivative exhibited striking red-shifted fluorescence and enhanced bipolar electrochemiluminescence. Furthermore, their intramolecular charge transfer properties were disclosed by …

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Advances in Targeted Therapy and Drugs for Advanced Colorectal Cancer

Peng Xu

Colorectal cancer (CRC) is one of the common malignant tumors of the digestive tract. Traditional conventional treatments primarily include surgery, chemotherapy, and radiotherapy. However, for advanced colorectal cancer, treatment often relies on drug rechallenge. Research on targeted therapy mainly focuses on molecular …

Synthesis of Carbazole-Based Electron Donor–Acceptor Architectures Enabling Ultrasensitive Epinephrine Detection

Jinjin Ding, H. Jia, Hui Xie, Jinling Zhang et autres

In this work, using carbazole as the electron donor and pyridinyl as the acceptor, we synthesized three novel donor–acceptor (D–A) architectures ( CzP s). Notably, all exhibited significant solvent-dependent fluorescence emission in the visible-light region. Interestingly, the antiaromatic diazocine core interrupted the …

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18F-FDG PET-based ensemble deep learning model for the prediction of lymphovascular invasion in colorectal cancer patients

Hongyue Zhao, Zhehao Lyu, Yexin Su, Huiting Zhang et autres

OBJECTIVE: F-fuorodeoxyglucose (FDG) positron emission tomography (PET) images in predicting lymphovascular invasion (LVI) in colorectal cancer (CRC) patients. METHODS: F-FDG PET/computed tomography were enrolled and assigned to the training cohort or the internal test cohort. Three inputs were determined according to the …

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Exploring the prognostic value of EBV DNA in advanced nasopharyngeal carcinoma treated with chemoradiotherapy using AI-based modeling

Yang Yang, Shun Lu, Lintao Li, Peng Xu et autres

Background: Epstein-Barr virus (EBV) DNA is a well-established biomarker in nasopharyngeal carcinoma (NPC), but its integration into artificial intelligence (AI)-based prognostic tools remains limited. This study aimed to develop and validate AI models incorporating EBV DNA load levels to predict progression-free survival …

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Comparison of endoscopic papillectomy and pancreatoduodenectomy for high-grade intraepithelial neoplasia of the duodenal papilla: a retrospective cohort study

Zhengwang Wang, Yuanyuan Chen, Ke Zhang, Xinyu Ge et autres

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Self-doped carbon nitride-enabled low-potential cathodic electrochemiluminescence immunosensor for ultrasensitive detection of neuron-specific enolase

Yu Du, Rui Feng, Kezhen Qi, Peng Xu et autres

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Multi-omics Analysis Reveals miR-7220-5p Alleviates N 2 O Addictive Behaviors via NR2B/ERK/CREB Signaling

Tianyi Yang, Yan Chen, Ren Ren, Yan Fang et autres

Nitrous oxide use disorder (NUD) has recently received increasing social concern for its sharp rise among young people. However, the underlying mechanisms of NUD remain largely unexplored, which obstructs treatment strategy development and may exacerbate the epidemic of N 2 O abuse. …

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Layout optimization of a dual-robot system for mirror milling of thin-walled parts

Chenghao Huang, P. H. Lin, Xianlei Shan, Bing Li et autres

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Characterization of novel anoikis-related genes as prognostic biomarkers and key determinants of the immune microenvironment in esophageal cancer

Yani Su, Mingxing Zhang, Peng Xu, Pengfei Wen et autres

Objective: Esophageal cancer (EC) ranks among the most prevalent malignancies globally and represents a significant and growing public health burden. This study aimed to construct a prognostic model leveraging anoikis-related genes (ARGs) to predict patient survival and elucidate the immunological microenvironment in …

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Synthesis, Properties, and Application of a Polyyne Propeller

Peng Xu, Yongkang Zuo, Ning‐Ning Sun, Kang Yin et autres

Abstract A polyyne propeller was synthesized and the structure was characterized via 1H, 13C NMR and FT-IR, etc. Subsequently, its photophysical properties in a series of solvents were investigated by steady-state spectroscopy and transient spectroscopy. Intriguingly, the polyyne in ethyl acetate solution …

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