Claire Laird

Combining Anion Exchange and Size Exclusion Chromatography for Extracellular Vesicle Enrichment from Small Volumes of Human and Mouse Plasma for Quantitative Proteomics

Felicity Dunlop, Shaun A. Mason, Nadia Hafizi Rastabi, Sarah E. Alexander et autres

Abstract Extracellular vesicles (EVs) are promising biomarkers, yet their proteomic analysis from plasma is hampered by low abundance and co-purification of contaminants (e.g., lipoproteins, platelets) and technical variability, particularly in small-volume animal models. We developed and validated a modular protocol integrating Size …

au (code pays fourni par la source)

Skeletal muscle TDP-43 aggregation drives progressive motor dysfunction and neurodegeneration with potential for functional recovery after clearance

Shuzhao Zhuang, Nadia Hafizi Rastabi, Saeedeh Robatjazi, Anushka Podar et autres

Abstract Understanding the mechanisms driving TDP-43 pathology is essential for combating amyotrophic lateral sclerosis and other neurodegenerative diseases. To investigate the contribution of skeletal muscle to disease onset, progression, and recovery, we generated an inducible, muscle-specific TDP-43 mouse model. Cytoplasmic aggregation of …

au, nz (code pays fourni par la source)

DMD – ANIMAL MODELS

Angus Lindsay, Adam J. Trewin, Paul A. Della Gatta, Claire Laird et autres

au (code pays fourni par la source)