Li Zhu

AX-024 Inhibits Antigen-Specific T-Cell Response and Improves Intracerebral Hemorrhage Outcomes in Mice

Shuai Chen, Peiji Fu, Yousef Rastegar‐Kashkooli, Li Zhu et autres

BACKGROUND: Stroke-induced opposite T-cell responses in the peri-lesion area and periphery worsen stroke outcomes by aggravating brain injury or increasing infectious complications, respectively. Despite their well-known role in T lymphocyte activation, the impact of TCRs (T-cell receptors) on stroke remains poorly understood. …

cn (code pays fourni par la source)

Type I interferon-stimulated genes predict clinical response to belimumab in systemic lupus erythematosus

Hanchao Li, Bomiao Ju, Li Zhu, Jing Zhang et autres

cn (code pays fourni par la source)

Toll-Like Receptors Mediate Opposing Dendritic Cell Effects on Treg/Th17 Balance in Mice With Intracerebral Hemorrhage

Li Zhu, Junkui Shang, Yinuo Li, Zhiying Zhang et autres

BACKGROUND: Dendritic cells (DCs) regulate the immune response associated with T lymphocytes, but their role in stroke remains unclear. In this study, we investigated the causal relationship between DCs and T-cell response in intracerebral hemorrhage (ICH) by focusing on TLRs (toll-like receptors) …

cn (code pays fourni par la source)

The rapid inhibition of B-cell activation markers by belimumab was associated with disease control in systemic lupus erythematosus patients

Jing Wang, Bomiao Ju, Li Zhu, Hanchao Li et autres

Objective: To examine the kinetics of B cell subsets and activation markers in the early stage of belimumab treatment and their correction with treatment response. Methods: We enrolled 27 systemic lupus erythematosus (SLE) patients receiving 6 months belimumab treatment. Flow cytometry was …

cn (code pays fourni par la source)

Peripheral immunophenotypes associated with the flare in the systemic lupus erythematosus patients with low disease activity state

Jian Zheng, Li Zhu, Bomiao Ju, Jing Zhang et autres

cn (code pays fourni par la source)

Interactions between the Autonomic Nervous System and the Immune System after Stroke

Li Zhu, Leo Huang, Anh Cong Tuan Le, Tom J. Wang et autres

Abstract Acute stroke is one of the leading causes of morbidity and mortality worldwide. Stroke‐induced immune‐inflammatory response occurs in the perilesion areas and the periphery. Although stroke‐induced immunosuppression may alleviate brain injury, it hinders brain repair as the immune‐inflammatory response plays a …

cn, ca, us (code pays fourni par la source)