Haoquan Yu

Deciphering tRNA repertoires and translation coordination during mouse early embryogenesis by ORACLE-tRNAseq

Yun Li, Xin Wang, Ruofan Huang, Haoquan Yu et autres

Translational control is vital during the maternal-to-zygotic transition (MZT), yet the landscape of embryonic transfer RNA (tRNA) pools has been difficult to explore. Here, we develop Optimized Reaction for Accurate Capture of Low-input Entities tRNA Sequencing (ORACLE-tRNAseq), enabling robust tRNA profiling from …

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Spatiotemporally Resolved Mapping of Nuclear‐associated Protein Through Photocatalytic Proximity Labeling

Xiyun Luo, H. Z. Shi, Haoquan Yu, Ke Zhang et autres

ABSTRACT Spatiotemporal profiling of nuclear‐associated proteomes is crucial for elucidating disease mechanisms, identifying key therapeutic targets, and guiding the design of effective drugs. Currently, proximity labeling (PL) using genetically transfected enzymes or photocatalyst‐based probes has emerged as a powerful tool for proteomic …

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Synthesis of a novel C46 ceramide and its skin barrier repair effect verified by molecular dynamics and cellular assays

Hang Lu, Haoquan Yu, Ziheng Zhang, Yanqiu Mu et autres

Objective Ceramides play a critical role in skin barrier function. Here, we synthesized a novel long-chain ceramide, C46 EOP, via a sustainable catalyst-free route and elucidated its molecular mechanisms and barrier repair efficacy using an integrated computational-experimental strategy. Methods A novel C46 …

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Astragaloside IV and ceramide IIIB co-modified ferulic acid ethosomes: a promising novel approach for skin anti-aging

Zhixin Wen, Hang Lu, Haoquan Yu, Yiyuan Liu et autres

Ferulic acid (FA) has multiple anti-aging functions but is limited by poor solubility, low bioavailability, and unclear mechanism in skincare. To overcome these challenges, we have developed ferulic acid ethosomes (FA-ES) co-modified with astragaloside IV and ceramide IIIB. Stability of FA-ES was …

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Ferulic Acid Ethosomes: A Versatile Nanodelivery System for Anti-Ageing Interventions in Zebrafish and C. Elegans Aquatic Model Organisms

Zhixin Wen, Hang Lu, Haoquan Yu, Yiyuan Liu et autres

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UV-modification of Ag nanoparticles on α-MoC x for interface polarization engineering in electromagnetic wave absorption

Pengyuan Zhu, Yifan Kang, Xinglong Li, Haoquan Yu et autres

Based on bimetallic HZIF-ZnMo, a high-performance electromagnetic wave absorbing material with comprehensive conductivity loss, polarization loss and dielectric loss was obtained by graphiting and UV-modified silver nanoparticles.

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Remediation of PO43– and Ni2+ from aqueous solution by novel jarosite: competitive adsorption performance and mechanism

Rui Han, Shengtao Wang, Yilin Xu, Zhenxing Wang et autres

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Three-dimensional ordered macroporous ZIF-8 nanoparticle-derived nitrogen-doped hierarchical porous carbons for high-performance lithium–sulfur batteries

Xinxin Ji, Qian Li, Haoquan Yu, Xiaolin Hu et autres

after 50 cycles at a higher rate of 1C, and this enhanced cycling stability and rate capability demonstrate great practical application potential in Li-S battery systems.

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Activation of PhoBR under phosphate‐rich conditions reduces the virulence of Xanthomonas oryzae pv. oryzae

Dehong Zheng, Bingbing Xue, Yanan Shao, Haoquan Yu et autres

Summary The two‐component signal transduction system PhoBR regulates the adaptation to phosphate limitation and the virulence of many animal bacterial pathogens. However, PhoBR in phytopathogens has rarely been investigated. In this study, we found that PhoBR in Xanthomonas oryzae pv. oryzae ( …

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The global strategy employed by Xanthomonas oryzae pv . oryzae to conquer low-oxygen tension

Jianliang Wang, Jing Guo, Shasha Wang, Zhiyong Zeng et autres

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A two‐domain protein triggers heat shock pathway and necrosis pathway both in model plant and nematode

Lifang Ruan, Huihui Wang, Ge Cai, Donghai Peng et autres

The entomopathogen Bacillus thuringiensis is equipped with multiple virulent factors. The genome sequence of B. thuringiensis YBT1520 revealed the presence of a two-domain protein named Nel which is composed of a necrosis-inducing phytophthora protein 1-like domain found in phytopathogens and a ricin …

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