Emine Çağnur Ulukuş

Relationship Between EGFR Mutation Status and Clinicopathological Parameters in Non-Small Cell Lung Carcinomas and Correlation of PD-L1 Expression

Sumru Cagaptay, Anil Aysal Agalar, Kübra Canaslan, Duygu Gürel et autres

Background and Objectives: In this study, we investigate clinical and pathological parameters that may be associated with EGFR mutations. We aimed to contribute to the literature by understanding other potential clinical and pathological factors that could be useful in predicting patients with …

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Association of Molecular Classification with FIGO Stage and Survival Outcomes in Endometrial Cancer

Merve Keskinkılıç, Gül Polat, Zeynep Bayramoğlu, Anıl Aysal Ağalar et autres

Background and Objectives: Molecular classification has emerged as a key determinant of prognosis in endometrial cancer and has recently been incorporated into the 2023 FIGO staging system. Tumors are categorized into four molecular subgroups—POLE-mutated (POLEmut), p53-abnormal (p53abn), mismatch repair-deficient (dMMR), and no …

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Effect of dilation and curettage procedure on endometrial cancer invasion and spread

Orkun İlgen, Sefa Kurt, Eyuphan Ozgozen, Egehan Bilen et autres

Amaç: Dilatasyon ve küretaj (D&C), kadın doğum alanında yaygın bir işlemdir. D&C'nin endometriumu tahrip etme olasılığı olduğu bilinmektedir. Bu nedenle, bu işlem plasenta adezyon-invazyon bozuklukları ve Asherman sendromu için bir risk faktörüdür. Dolayısıyla, D&C, endometriyal kanser (EK) invazyonu ve yayılımı için olası …

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The Effect of MicroRNA 21 and MicroRNA 200b Expression on Carcinogenesis in Endometriosis-Associated Ovarian Cancers and Relationship with Clinicopathological Parameters

Esra Canan Kelten Talu, Emine Çağnur Ulukuş, Yasemin Çakır, Merih Güray Durak et autres

(1) Background and Objectives: Endometriosis is defined as the presence of endometrial glands and stroma outside the uterine cavity. It affects 5–15% of women of reproductive age. Ovarian cancer develops in approximately 1% of patients with endometriosis. Prediction of those with endometriosis …

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3424 Prognostic impact and validation of new molecular classification in endometrial cancer patients

Mehmet Varol, İlknur Bilkay Görken, Emine Çağnur Ulukuş, Sefa Kurt et autres

NOD1, NOD2, PYDC1, and PYDC2 gene polymorphisms in ovarian endometriosis

Hakan Kula, Beste Balbal, Onur Yavuz, Sefa Kızıldağ et autres

Background Endometriosis, a prevalent chronic gynecologic disorder, significantly impacts women’s health, with both genetic and environmental factors contributing to its heritability. Within the adaptive immune system, the NOD-like receptors (NLR) pathway plays pivotal roles in various autoinflammatory diseases, regulating interleukins, proinflammatory cytokines, …

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Prediction of adenomyosis according to revised definitions of morphological uterus sonographic assessment features

Onur Yavuz, Aslı Akdöner, Mehmet Eyüphan Özgözen, Begüm Ertan et autres

Objectives This study aimed to predict the diagnosis of adenomyosis by revised definitions of morphological uterus sonographic assessment (MUSA) features in individuals who had hysterectomy. Methods This was retrospective cohort research conducted at a tertiary facility. Between January 2022 and January 2023, …

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Morphomolecular Correlation and Clinicopathologic Analysis in Endometrial Carcinoma

Göksenil Bülbül, Tekincan Çağrı Aktaş, Anıl Aysal Ağalar, Safiye Aktaş et autres

Research groups have identified 4 groups [polymerase epsilon (POLE) mutant, mismatch repair-deficient, p53-abnormal, and no specific molecular profile)] reflecting the Tumor Cancer Genomic Atlas Research Network subgroups in endometrial carcinomas, improving the clinical applicability of molecular classification. We have analyzed the histopathologic …

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Effect of low uterine segment involvement on prognosis of early stage endometrial cancer

Aslı Akdöner, Sefa Kurt, Onur Yavuz, Emre Bayram et autres

AIM: Our aim is to investigate the effect of uterine lower segment involvement on prognosis of early-stage endometrial cancer cases diagnosed and treated in our clinic. MATERIALS AND METHODS: The file records of 316 cases reviewed retrospectively.Only stage I (a and b, …

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Endometrial pathologies in clinical follow-up of patients with hormone receptor-positive/negative breast cancer

Sefa Kurt, Samican Özmen, Onur Yavuz, Orkun İlgen et autres

Background/Aim: Breast cancer is the leading cause of cancer-related fatalities in women. Tamoxifen, a selective estrogen receptor modulator (SERM), is frequently employed for chemoprevention in hormone receptor (HR)-positive breast cancer patients due to its anti-estrogenic impact on breast tissue. Nevertheless, tamoxifen exhibits …

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Contribution of F-18 fluorodeoxyglucose PET/CT and contrast-enhanced thoracic CT texture analyses to the differentiation of benign and malignant mediastinal lymph nodes

Ogün Bülbül, Hande Melike Bülbül, Kemal Can Tertemiz, Gamze Çapa Kaya et autres

BACKGROUND: Texture analysis and machine learning methods are useful in distinguishing between benign and malignant tissues. PURPOSE: To discriminate benign from malignant or metastatic mediastinal lymph nodes using F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and contrast-enhanced computed tomography (CT) texture …

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Diagnostic Approach According to More Frequent Metastatic Sites: Liver, Lung, Bone, and Lymph Nodes

Anıl Aysal, Betül Gündoğdu, Burçin Pehlivanoğlu, Sümeyye Ekmekçi et autres

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