Yingpeng Peng

An open-label, single-center phase II trial of mitoxantrone hydrochloride liposome combined with programmed death-1 (PD-1) inhibitors for pretreated recurrent or metastatic nasopharyngeal carcinoma.

You Rui, Jijin Yao, Youping Liu, Mengqi Long et autres

6047 Background: Liposomal mitoxantrone (Lipo-MIT) in combination with programmed death-1 (PD-1) inhibitors exhibits potential synergistic antitumor effects. This study aimed to evaluate the efficacy and safety of this regimen in patients with pretreated recurrent/metastatic nasopharyngeal carcinoma (R/M NPC). Methods: This was a …

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Discontinuation of immunotherapy and its effect on prognosis in recurrent or metastatic nasopharyngeal carcinoma patients: a retrospective analysis

Yingpeng Peng, Xi Chu, Dasong Zha, Linghan Meng et autres

PURPOSE: Immunotherapy has become the standard first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (R/M NPC). This study aims to explore the impact of discontinuation of immunotherapy within 1 year on survival prognosis in patients with R/M NPC. MATERIALS AND METHODS: We …

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RNA adenosine modification writers define characteristics of immunity and prognosis in head and neck squamous cell carcinoma

Rong Wang, Yingpeng Peng, Ruotong Chen, Rui Liu et autres

PURPOSE: To identify potential roles of RNA modification patterns in immunotherapy and prognosis in head and neck squamous cell carcinoma (HNSCC). METHODS: We performed a multiomics analysis of 26 "writers" from four major adenine RNA modifications in 866 HNSCC samples from 3 …

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Development and Validation of Survival Prediction Models for Patients With Pineoblastomas Using Deep Learning: A SEER ‐Based Study

Xuanzi Li, Shuai Yang, Yingpeng Peng, Xueqiang You et autres

PURPOSE: Pineoblastomas (PBs) are rare central nervous system tumors primarily affecting children and adolescents, with limited data on clinical characteristics and survival outcomes. Prognosis prediction models for this disease are lacking. The purpose of this study was to develop deep learning (DL) …

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Combination of Tim-3 blockade TQB2618 with penpulimab and chemotherapy in the first-line treatment of recurrent/metastatic nasopharyngeal carcinoma (R/M NPC): A multicenter, single-arm, two-cohort, phase 2 study.

Qingqing Cai, Jun Ma, Kunyu Yang, Siyang Wang et autres

6031 Background: T cell immunoglobulin and mucin domain molecule 3 (Tim-3) is an inhibitory immune checkpoint receptor that negatively regulates the immune response. This multicenter, single-arm, two-cohort, phase 2 study (NCT05563480) aimed to explore the efficacy and safety of TQB2618, a novel …

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Two cycles of neoadjuvant therapy with low-dose radiotherapy, PD-1 inhibitor tislelizumab, albumin-bound paclitaxel, and cisplatin for resectable locally advanced head and neck squamous cell carcinoma (NeoRTPC02): A phase II, open-label, single-arm trial.

Zhigang Liu, Dong Wang, Guanjun Li, Muhua Yi et autres

6039 Background: Despite standard treatments, mortality rates remain high in locally advanced head and neck squamous cell carcinoma (LA HNSCC). Neoadjuvant immunotherapy combined with chemotherapy has improved response rates, but further enhancement is needed. Recent studies suggest that low-dose radiotherapy (LDR) can …

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Matrix metallopeptidase 2-responsive curcumin-loaded nanoparticles-induced signal transducer and activator of transcription 3 inhibition suppresses glioblastoma multiforme growth via enhancing nuclear factor erythroid 2-related factor 2 activity

Fujie Jia, Yingpeng Peng, Xiaobing Li, Shuai Yang et autres

This study investigated the inhibitory effects of matrix metallopeptidase 2 (MMP2)-responsive curcumin-loaded nanoparticles on glioblastoma multiforme (GBM), and elucidated their underlying mechanisms. The methods employed included the Cell Counting Kit-8 viability assay, colony formation assay, flow cytometry for apoptosis analysis, wound healing …

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Clinical and Genomic Phenotype of Brain Metastasis in Nasopharyngeal Carcinoma

Yingpeng Peng, Shuai Yang, Jianzhong He, Qiaodan Liu et autres

Brain metastasis in nasopharyngeal carcinoma is a rare but poor prognosis clinical problem. This study aims to investigate the clinical characteristics and identify the genomic profiling of nasopharyngeal carcinoma brain metastasis. Patients with a diagnosis of nasopharyngeal carcinoma who visited at the …

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Development and Validation of a Deep Learning Model to Predict Survival in Breast Cancer Patients

Xuanzi Li, Shuai Yang, Yingpeng Peng, Qiaodan Liu et autres

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Deep-learning based 3-year survival prediction of pineoblastoma patients

Xuanzi Li, Shuai Yang, Qiaodan Liu, Siyang Wang et autres

Abstract Purpose Pineoblastoma (PB) is an extremely uncommon and highly aggressive malignancy that originates from the pineal gland, more frequently occurs in young children. Due to the rare nature, little is known about its prognostic implications and survival outcomes. Existing methods for …

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Neoadjuvant low-dose radiotherapy, tislelizumab, combined with albumin-bound paclitaxel and cisplatin in resectable locally advanced head and neck squamous cell carcinoma (NeoRTPC02): The first-stage result from an open label, single-arm, two stage, phase II clinical trial.

Zhigang Liu, Yingpeng Peng, Xiaotao Huang, Lizhong Liang et autres

6078 Background: Neoadjuvant immunotherapy and chemotherapy has been explored in phase I/II clinical studies in head and neck squamous cell carcinoma (HNSCC), confirming its safety and efficacy. However, the pathological complete response (pCR) / major pathological response (MPR) rate still needed for …

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Prognostic significance of carboxypeptidase Q and its methylation in glioblastoma

Qiaodan Liu, Rong Wang, Zizi Li, Yingpeng Peng et autres

Background: Glioblastoma (GBM) is a highly aggressive intracranial malignant tumor. The role of carboxypeptidase Q (CPQ) in GBM remains unknown. This study was to investigate the prognostic significance of CPQ and its methylation in GBM. Methods: We collected data from The Cancer …

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