Paulette Mhawech‐Fauceglia

ShapeUpLMD: An Automated Pipeline for Spatially Optimized Laser Microdissection in Multi-omic Tissue Profiling

J. Schaaf, Dave Mitchell, Jonathan Ogata, Sakiyah TaQee et autres

Abstract Laser microdissection (LMD) enables enrichment of defined cellular populations from heterogeneous tissues, providing histologically-resolved molecular profiles with spatial resolution. However, the absence of standardized methods for generating optimized regions of interest (ROIs) limits reproducibility and scalability for spatial multi-omic workflows. To …

us (code pays fourni par la source)

IDENTIFYING RESPONDERS TO ENZALUTAMIDE IN ADVANCED ENDOMETRIAL CANCER: THE ENPAC STUDY

Anil K. Sood, Elaine Stur, Shannon N. Westin, Bryan Fellman et autres

us (code pays fourni par la source)

Quantitative proteomics identifies conserved proteins and altered regulation of mucin-16 in low grade serous ovarian cancers

Christopher M. Tarney, Paulette Mhawech‐Fauceglia, Jonathan Ogata, Julie Oliver et autres

BACKGROUND: Low-grade serous ovarian carcinoma (LGSOC) is a rare and largely chemoresistant subtype of epithelial ovarian cancer. Unlike treatment for high-grade serous ovarian cancer (HGSOC), management options for LGSOC patients are limited, in part, due to a lack of deep molecular characterization …

us (code pays fourni par la source)

Linking human papillomavirus infections to cervical cancer driver mutations and survival

Ahmed Hussain, Chunqiao Tian, Christopher M. Tarney, Thomas Beltran et autres

us, de (code pays fourni par la source)

Integrated analysis of clinical presentation, prognostic factors, treatment options, survival and genomic drivers in cervical clear cell carcinoma compared with usual-type adenocarcinoma

Ryan J. McLaughlin, Chunqiao Tian, Paulette Mhawech‐Fauceglia, Pouya Javadian et autres

us, de (code pays fourni par la source)

Survival in stage I-IV cervical squamous cell carcinoma, adenocarcinoma or adenosquamous carcinoma

Pouya Javadian, Chunqiao Tian, Ahmed Hussain, Ryan J. McLaughlin et autres

us, de (code pays fourni par la source)

Deep quantitative proteomics identifies elevated MUC16 in low- compared to high-grade serous ovarian carcinoma

Christopher M. Tarney, Nicholas W. Bateman, Paulette Mhawech‐Fauceglia, Jonathan Ogata et autres

us (code pays fourni par la source)

Author Correction: Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities

Nicholas W. Bateman, Tamara Abulez, Anthony R. Soltis, Andrew McPherson et autres

In the original version of this article, the wrong file was inadvertently supplied for Supplementary Data 15. The original article has been corrected.

us, au, gb, ca (code pays fourni par la source)

Quantitative Proteomics Identifies Conserved Proteins and Altered Regulation of Mucin-16 in Low Grade Serous Ovarian Cancers

Christopher M. Tarney, Paulette Mhawech‐Fauceglia, Jonathan Ogata, Julie Oliver et autres

Abstract Background Low-grade serous ovarian carcinoma (LGSOC) is a rare and largely chemoresistant subtype of epithelial ovarian cancer. Unlike treatment for high-grade serous ovarian cancer (HGSOC), management options for LGSOC patients are limited, in part, due to a lack of deep molecular …

us (code pays fourni par la source)

The association of histopathologic features after neoadjuvant chemo-immunotherapy with clinical outcome: Sub-analyses from the randomized double-blinded, placebo-controlled, Phase III IMagyn050/GOG3015/ENGOT-ov39 study

Paulette Mhawech‐Fauceglia, Denis M. McCarthy, Akiko Tonooka, Giovanni Scambia et autres

OBJECTIVE: Histopathologic characteristics after neoadjuvant chemotherapy (NACT) may correlate with outcome. This study evaluates histopathologic features after immunotherapy and NACT/bevacizumab, and associated clinical outcomes. METHODS: Evaluable tissue from IMagyn050/GOG3015/ENGOT-ov39 patients from prespecified anatomic sites from interval cytoreductive surgery (ICS) after NACT/bevacizumab plus …

jp, it, es, cz, us, fr (code pays fourni par la source)

Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities

Nicholas W. Bateman, Tamara Abulez, Anthony R. Soltis, Andrew McPherson et autres

We performed a deep proteogenomic analysis of bulk tumor and laser microdissection enriched tumor cell populations from high-grade serous ovarian cancer (HGSOC) tissue specimens spanning a broad spectrum of purity. We identified patients with longer progression-free survival had increased immune-related signatures and …

us, au, gb, ca (code pays fourni par la source)

Bilateral Ovarian Serous Borderline Tumor with Non-Invasive Endometrial Implants

Melissa Bou Malham, Jordy Mehawej, Andreas Filippaios, Christina L. Kushnir et autres

Herein, we are presenting a case of a 33-year-old woman who presented to the emergency department complaining of persistent lower abdominal pain of one-day duration. Physical examination revealed abdominal tenderness with right lower quadrant rebound tenderness. Computed tomography abdomen/pelvis showed a 6 …

us (code pays fourni par la source)