Martin Fuhrmann

Constrained inhibitory plasticity stabilizes competitive STDP networks

Fabrizio Musacchio, Martin Fuhrmann

Toward standardized behavioral analysis in IntelliCage experiments

Fabrizio Musacchio, Martin Fuhrmann

Abstract Automated home-cage systems measure individual behavior in social groups for days to months. Among these systems, the IntelliCage has become a widely used platform for longitudinal and socially embedded behavioral phenotyping. Yet the analysis layer often remains less standardized than the …

de (code pays fourni par la source)

MotilA: A pipeline for microglial fine process motility analysis

Fabrizio Musacchio, Sophie Crux, Felix Nebeling, Nala Gockel et autres

🚀 MotilA v1.2.0 This release is a major internal refactor of the MotilA package, where we have modularized MotilA's monolithic codebase into focused submodules in order to improve maintainability and readability and to ensure future extensibility. We also exchanged the batch processing …

Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence

Xin Yan, Christina Georgopoulou, Hang‐Mao Lee, Ala Ahrari et autres

Abstract Aging-associated loss of chromatin compaction is linked to derepression of retrotransposable elements (RTEs) in mouse and human tissues. Whether such RTE transcription contributes to the microglia activation that is common in aged brains is unknown. Here, we show that DAXX, a …

de, nl, cn, sk, us, gb (code pays fourni par la source)

CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser‐Induced Lesions

Jens Wagner, Henrike Antony, Cornelia Hoyer, K. D. Lundgren et autres

Microglia are innate immune cells of the central nervous system (CNS). They extend their processes and migrate toward injuries in vivo. However, how the fractalkine receptor (CX3CR1) influences microglial migration remains unknown. Label-free proteomic profiling predicted changes in Ras homology family (RHO)-signaling …

de, fi, pl (code pays fourni par la source)

ZenReg: A modular Python platform for fast and memory-efficient N-dimensional microscopy image registration

Fabrizio Musacchio, Martin Fuhrmann

Abstract Motion artifacts are almost unavoidable in functional time-lapse and structural volumetric multiphoton microscopy. They arise from respiration, heartbeat, locomotion, awake behavior, instrument heating, mechanical vibration, and slow drift, while the recorded signal is often photon-limited, blurred by scattering, and biologically time …

de (code pays fourni par la source)

MotilA: A pipeline for microglial fine process motility analysis

Fabrizio Musacchio, Sophie Crux, Felix Nebeling, Nala Gockel et autres

🚀 MotilA v1.1.3 This release adds optional plain-text sidecar exports for tabular outputs while keeping Excel as the default format for full backward compatibility. Optional CSV and YAML table exports MotilA now supports optional plain-text sidecar exports for tabular outputs while keeping …

MotilA: A pipeline for microglial fine process motility analysis

Fabrizio Musacchio, Sophie Crux, Felix Nebeling, Nala Gockel et autres

🚀 MotilA v1.1.2 August 11, 2026 This is just a minor post-v1.1.1 release to fix a small issue in pyproject.toml: Since MotilA runs now with OMIO, which requires Python 3.12 or higher, the requires-python field in pyproject.toml has been updated to reflect …

MotilA: A pipeline for microglial fine process motility analysis

Fabrizio Musacchio, Sophie Crux, Felix Nebeling, Nala Gockel et autres

🚀 MotilA v1.1.1 August 11, 2026 This release introduces support for additional input formats and axis configurations via OMIO, along with several other improvements and bug fixes. Flexible image I/O via OMIO MotilA now uses OMIO for image reading and stack-style TIFF …

CellColoc: A modular, open-source workflow for cell colocalization, segmentation, and feature extraction in microscopy images

Fabrizio Musacchio, Henrike Antony, Arush Baijal, Marie Denise Roggan et autres

Abstract Quantitative cell colocalization in fluorescence microscopy often depends on ad hoc combinations of image loading, segmentation, region selection, manual inspection, and spreadsheet post-processing. Such workflows are difficult to transfer across projects and often obscure how intermediate results were produced. We present …

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CellColoc example data

Fabrizio Musacchio, Henrike Antony, Arush Baijal, Denise Marie Hoffmann et autres

Example data for CellColoc This Zenodo record contains example and validation data for testing, demonstrating, and reproducing analyses performed with CellColoc, an open-source, script-driven workflow for image-based cell segmentation, object-based marker colocalization, regional occupancy analysis, and per-cell feature extraction. The record contains …

de (code pays fourni par la source)

CellColoc example data

Fabrizio Musacchio, Henrike Antony, Arush Baijal, Denise Marie Hoffmann et autres

Example data for CellColoc This Zenodo record contains example and validation data for testing, demonstrating, and reproducing analyses performed with CellColoc, an open-source, script-driven workflow for image-based cell segmentation, object-based marker colocalization, regional occupancy analysis, and per-cell feature extraction. The record contains …

de (code pays fourni par la source)