Filippo M. Rijli

Polycomb chromatin topology enables long-range enhancer recruitment during craniofacial development

Yousra Ben Zouari, Onkar Joshi, Adwait Salvi, Sandra Kessler et autres

Little is known about how three-dimensional chromatin topology shapes mammalian craniofacial development. In mouse cranial neural crest cells, a Polycomb Repressive Complex 2 (PRC2)-dependent chromatin architecture is established before migration. This configuration maintains craniofacial gene promoters poised and connects them with distal …

ch, dk, de, nl, fr (code pays fourni par la source)

Comparing Trigeminal Nerve Branches in Lampreys and Gnathostomes Reveals Evolutionary Changes in Vertebrate Oral Nerve Innervation

Yuki Nakanishi, Motoki Tamura, Fumiaki Sugahara, Nono Kawada et autres

ABSTRACT The trigeminal nerve consists of three major branches or rami (r) in jawed vertebrates: the ophthalmic (rV 1 ), maxillary (rV 2 ), and mandibular (rV 3 ), with rV 2 and rV 3 innervating the upper and lower jaws, respectively. …

jp, es, ch (code pays fourni par la source)

Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction

Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí-Jou et autres

Functional elastic cartilage remains an unmet challenge in regenerative medicine, limiting reconstructive options for children born with microtia, the congenital malformation of the auricle. The current gold standard treatment relies on harvesting rib cartilage, an invasive procedure associated with donor site morbidity, …

Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction

Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou et autres

ABSTRACT Functional elastic cartilage remains an unmet challenge in regenerative medicine, limiting reconstructive options for children born with microtia, the congenital malformation of the auricle. The current gold standard treatment relies on harvesting rib cartilage, an invasive procedure associated with donor site …

ch (code pays fourni par la source)

Tissue Engineered Elastic Cartilage-Mimetic Auricular Grafts for Ear Reconstruction

Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou et autres

Abstract Patients born with microtia, the congenital malformation of the external ear, face substantial psychosocial strain. Current reconstruction relies on harvesting rib cartilage, an invasive procedure associated with donor site morbidity and unnaturally stiff ears due to the use of hyaline cartilage. …

ch (code pays fourni par la source)

Primary Cell Cultures in Neurobiology: Optimized Protocol for Culture of Mouse Fetal Hindbrain Neurons

Hadrien Glibert, Laure Bridoux, Maëlle Palate, Coralie Piget et autres

Primary cultures of neural cells are important key tools for basic and translational neuroscience research. These primary cell cultures are classically generated from the rodent brain hippocampus or cortex and optimized for enrichment in neurons at the expense of glial cells. Importantly, …

be, fr, ch (code pays fourni par la source)

Chromatin regulation of neuronal activity-dependent gene programs in circuit formation and plasticity

Gabriele Pumo, Filippo M. Rijli

Neuronal activity-dependent transcription is crucial for the development and plasticity of neuronal circuits. At the chromatin level, the induction of neuronal activity-regulated genes is orchestrated through various mechanisms, including the deposition of histone modifications at regulatory elements, the binding of transcriptional activators …

ch (code pays fourni par la source)

A prenatal window for enhancing spatial resolution of cortical barrel maps

Mar Aníbal-Martínez, Lorenzo Puche-Aroca, Elena Pérez-Montoyo, Gabriele Pumo et autres

Precise mapping of peripheral inputs onto cortical areas is essential for accurate sensory processing. In the mouse primary somatosensory cortex, mystacial whiskers correspond to large, well-defined barrels, while upper lip whiskers form smaller, less distinct barrels. These differences are traditionally attributed to …

es, ch (code pays fourni par la source)

Genetic identification of medullary neurons underlying congenital hypoventilation

Ke Cui, Yiling Xia, Abhisarika Patnaik, Aikaterini Salivara et autres

Mutations in the transcription factors encoded by PHOX2B or LBX1 correlate with congenital central hypoventilation disorders. These conditions are typically characterized by pronounced hypoventilation, central apnea, and diminished chemoreflexes, particularly to abnormally high levels of arterial PCO 2 . The dysfunctional neurons …

de, fr, ch (code pays fourni par la source)

A prenatal window for enhancing spatial resolution of cortical barrel maps

Mar Aníbal-Martínez, Lorenzo Puche-Aroca, Gabriele Pumo, M. Pilar Madrigal et autres

ABSTRACT Precise mapping of peripheral inputs onto cortical areas is required for appropriate sensory processing. In the mouse primary somatosensory cortex, mystacial whiskers are represented in large barrels, while upper lip whiskers are in smaller, less defined barrels. Barrel size and definition …

es, ch (code pays fourni par la source)

Comparative analysis of Hmx expression and the distribution of neuronal somata in the trigeminal ganglion in lamprey and shark: insights into the homology of the trigeminal nerve branches and the evolutionary origin of the vertebrate jaw

Motoki Tamura, Ryota Ishikawa, Yuki Nakanishi, Juan Pascual‐Anaya et autres

Abstract The evolutionary origin of the jaw remains one of the most enigmatic events in vertebrate evolution. The trigeminal nerve is a key component for understanding jaw evolution, as it plays a crucial role as a sensorimotor interface for the effective manipulation …

jp, es, ch (code pays fourni par la source)

BRAIN AREAS FOR SOMATOTOPIC REPRESENTATIONS ARE SET EMBRYONICALLY IN THE MOUSE SOMATOSENSORY SYSTEM

Mar Aníbal-Martínez, Lorenzo Puche-Aroca, Daniel Torres, Gabriele Pumo et autres

Facial somatosensory territories are represented in devoted cortical maps for precise sensory processing. In rodents, there are two main facial whisker patterns in the primary somatosensory cortex, those corresponding to the mystacial whiskers represented in the postero-medial barrel subfield (PMBSF) and those …

es, ch (code pays fourni par la source)