Michael E. Richett

Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives

Mary M. Mader, Chuan Shih, Eileen L. Considine, Alfonso de Dios et autres

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Acyl Sulfonamide Anti-Proliferatives: Benzene Substituent Structure−Activity Relationships for a Novel Class of Antitumor Agents

Karen L. Lobb, Philip A. Hipskind, James A. Aikins, Enrique L. Álvarez et autres

Two closely related diaryl acylsulfonamides were recently reported as potent antitumor agents against a broad spectrum of human tumor xenografts (colon, lung, breast, ovary, and prostate) in nude mice. Especially intriguing was their activity against colorectal cancer xenografts. In this paper, rapid …

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ChemInform Abstract: Diamino Benzo[b]thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors. Part 6. Further Focus on the Contracted C4′‐Side Chain Analogues.

Kumiko Takeuchi, Todd J. Kohn, Richard W. Harper, Ho‐Shen Lin et autres

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article …

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Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: Further focus on the contracted C4′-side chain analogues

Kumiko Takeuchi, Todd J. Kohn, Richard W. Harper, Ho‐Shen Lin et autres

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Diamino Benzo[b]thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors. 5. Potency, Efficacy, and Pharmacokinetic Properties of Modified C-3 Side Chain Derivatives

Daniel J. Sall, Dianna L. Bailey, Jolie A. Bastian, John A. Buben et autres

A systematic investigation of the structure-activity relationships of the C-3 side chain of the screening hit 1a led to the identification of the potent thrombin inhibitors 23c, 28c, and 31c. Their activities (1240, 903, and 1271 x 10(6) L/mol, respectively) represent 2200- …

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Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2: sidechain optimization and demonstration of in vivo efficacy

Minsheng Zhang, Dianna L. Bailey, Jolie A. Bastian, Steve Briggs et autres

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Synthesis of 4α-(2-propenyl)-5,6-secocholestan-3α-ol, a Novel B-ring Seco Analog of the Hypocholesterolemic Agent 4α-(2-propenyl)-5α-cholestan-3α-ol

Ho‐Shen Lin, Ashraff A. Rampersaud, Michael E. Richett, Lisa S. Beavers et autres

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