Carlton L. Pavy

Neurosteroid replacement therapy using tiagabine and zuranolone restores cerebellar neurodevelopment and reduces hyperactive behaviour following preterm birth

Carlton L. Pavy, Julia C. Shaw, Hannah K. Palliser, Roisin A. Moloney et autres

Preterm birth exposes the neonate to hypoxic-ischaemic and excitotoxic insults that impair neurodevelopment and are magnified by the premature loss of placentally supplied, inhibitory neurosteroids. The cerebellum is a neuronally dense brain region, which undergoes critical periods of development during late gestation, …

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Neurosteroid replacement approaches for improving outcomes after compromised pregnancies and preterm birth

Jonathan J. Hirst, Hannah K. Palliser, Carlton L. Pavy, Julia C. Shaw et autres

• Allopregnanolone has a key role in the fetus with higher levels than after birth. • Placental allopregnanolone protects fetus and promotes development. • Maternal stressors suppress placental synthesis and fetal development. • Preterm birth leads to an early loss of allopregnanolone-mediated …

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Ganaxolone Therapy After Preterm Birth Restores Cerebellar Oligodendrocyte Maturation and Myelination in Guinea Pigs

Carlton L. Pavy, Julia C. Shaw, Rebecca Maree Dyson, Hannah K. Palliser et autres

The postnatal environment is challenging for the preterm neonate with exposure to hypoxic and excitotoxic events, amplified by premature loss of placentally derived neurosteroids. Between preterm birth and term equivalent age (TEA), cerebellar development continues despite these challenges. We hypothesize that neurosteroid …

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Zuranolone therapy protects frontal cortex neurodevelopment and improves behavioral outcomes after preterm birth

Roisin A. Moloney, Hannah K. Palliser, Carlton L. Pavy, Julia C. Shaw et autres

BACKGROUND: Preterm birth is associated with brain injury and long-term behavioral abnormalities, for which there are limited prevention options. When born preterm, infants prematurely lose placental neurosteroid (allopregnanolone) support. This increases the risk of excitotoxic damage to the brain, which increases the …

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Author response for "Zuranolone therapy protects frontal cortex neurodevelopment and improves behavioral outcomes after preterm birth"

Roisin A. Moloney, Hannah K. Palliser, Carlton L. Pavy, Julia C. Shaw et autres

Protection from oxygen–glucose deprivation by neurosteroid treatment in primary neurons and oligodendrocytes

Roisin A. Moloney, Carlton L. Pavy, Richard G. S. Kahl, Hannah K. Palliser et autres

Abstract Preterm birth results in an increased risk of neonatal brain injury and neurobehavioural disorders. Despite the seriousness of these adverse outcomes, there are currently no effective therapies to protect the vulnerable developing brain. We propose that neurosteroid replacement therapy may be …

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Ongoing effects of preterm birth on the dopaminergic and noradrenergic pathways in the frontal cortex and hippocampus of guinea pigs

Roisin A. Moloney, Hannah K. Palliser, Rebecca Maree Dyson, Carlton L. Pavy et autres

Children born preterm have an increased likelihood of developing neurobehavioral disorders such as attention-deficit hyperactivity disorder (ADHD) and anxiety. These disorders have a sex bias, with males having a higher incidence of ADHD, whereas anxiety disorder tends to be more prevalent in …

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Potential for a cerebellar role in moderate-late preterm associated behavioural disorders

Carlton L. Pavy, Julia C. Shaw, Roisin A. Moloney, Hannah K. Palliser et autres

Preterm birth is known to cause impaired cerebellar development, and this is associated with the development of neurobehavioral disorders. This review aims to identify the mechanisms through which preterm birth impairs cerebellar development and consequently, increases the risk of developing neurobehavioral disorders. …

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Dual isolation of primary neurons and oligodendrocytes from guinea pig frontal cortex

Roisin A. Moloney, Carlton L. Pavy, Richard G. S. Kahl, Hannah K. Palliser et autres

Primary cell culture is a technique that is widely used in neuroscience research to investigate mechanisms that underlie pathologies at a cellular level. Typically, mouse or rat tissue is used for this process; however, altricial rodent species have markedly different neurodevelopmental trajectories …

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Examining Neurosteroid-Analogue Therapy in the Preterm Neonate For Promoting Hippocampal Neurodevelopment

Julia C. Shaw, Rebecca Maree Dyson, Hannah K. Palliser, Ryan Phillip Sixtus et autres

Background: Preterm birth can lead to brain injury and currently there are no targeted therapies to promote postnatal brain development and protect these vulnerable neonates. We have previously shown that the neurosteroid-analogue ganaxolone promotes white matter development and improves behavioural outcomes in …

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