Carboxypeptidase B2 (CPU, TAFIa)
Joachim C. Mertens, Karen Claesen, Dirk Hendriks
0 citationsHandbook of Proteolytic Enzymes
Dirk Hendriks
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124Publications signalées
3306Citations signalées
1Affiliations récentes
Institutions déclarées
Domaines associés
Peptidase Inhibition and AnalysisBlood Coagulation and Thrombosis MechanismsProtease and Inhibitor MechanismsNeuropeptides and Animal PhysiologyCoagulation, Bradykinin, Polyphosphates, and Angioedema
Publications récentes
List of contributors
Marija Abrami, Hideki Adachi, Zach Adam, Michael W. W. Adams et autres
0 citationsHandbook of Proteolytic Enzymes
ProCPU Is Expressed by (Primary) Human Monocytes and Macrophages and Expression Differs between States of Differentiation and Activation
Karen Claesen, Joni De Loose, Pieter Van Wielendaele, Emilie De bruyn et autres
1 citationInternational Journal of Molecular Sciences
Atorvastatin downregulates plasma procarboxypeptidase U concentrations and improves fibrinolytic potential dose-dependently in hyperlipidemic individuals
Karen Claesen, Yani Sim, Shahir Basir, Simon De Belder et autres
0 citationsJournal of Thrombosis and Haemostasis
Proline-specific peptidase activities (DPP4, PRCP, FAP and PREP) in plasma of hospitalized COVID-19 patients
An Bracke, Emilie De Hert, Michelle De bruyn, Karen Claesen et autres
18 citationsClinica Chimica Acta
Activation of the Carboxypeptidase U (CPU, TAFIa, CPB2) System in Patients with SARS-CoV-2 Infection Could Contribute to COVID-19 Hypofibrinolytic State and Disease Severity Prognosis
Karen Claesen, Yani Sim, An Bracke, Michelle De bruyn et autres
5 citationsJournal of Clinical Medicine
Carboxypeptidase U (TAFIa) Is Rapidly Activated and Deactivated Following Thrombolysis and Thrombectomy in Stroke Patients
Joachim C. Mertens, Vanessa Blanc‐Guillemaud, Karen Claesen, Pere Cardona et autres
2 citationsTranslational Stroke Research
Pleiotropic Effects of Atorvastatin Result in a Downregulation of the Carboxypeptidase U System (CPU, TAFIa, CPB2) in a Mouse Model of Advanced Atherosclerosis
Karen Claesen, Lynn Roth, Joachim C. Mertens, Karlijn Susanna Francisca Maria Hermans et autres
2 citationsPharmaceutics
Effect of Statin Therapy on the Carboxypeptidase U (CPU, TAFIa, CPB2) System in Patients With Hyperlipidemia: A Proof-of-concept Observational Study
Karen Claesen, Joachim C. Mertens, Shahir Basir, Simon De Belder et autres
5 citationsClinical Therapeutics
Carboxypeptidase U (CPU, TAFIa, CPB2) in Thromboembolic Disease: What Do We Know Three Decades after Its Discovery?
Karen Claesen, Joachim C. Mertens, Dorien Leenaerts, Dirk Hendriks
30 citationsInternational Journal of Molecular Sciences
Favourable safety profile of S62798, a potent TAFIa (activated thrombin-activatable fibrinolysis inhibitor) inhibitor, in first-in-man study in healthy subjects
F Petit Dop, Mathieu Latreille, L Guicherd, Joachim C. Mertens et autres
5 citationsEuropean Heart Journal
Selective inhibition of carboxypeptidase U may reduce microvascular thrombosis in rat experimental stroke
Joachim C. Mertens, William Boisseau, Dorien Leenaerts, Lucas Di Meglio et autres
9 citationsJournal of Thrombosis and Haemostasis
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