Daniel Ruderfer

Atypical Presentation of Rapidly Progressive Guillain–Barré Syndrome With Dysautonomia in an Adolescent With Persistent Mycoplasma pneumoniae Infection: A Case Report

Madhu Parna Chakrabarti, Richard Sultan, Daniel Ruderfer, Katherine Hickey

Background Guillain–Barré syndrome (GBS) is an acute immune‐mediated polyradiculoneuropathy and the leading cause of acute flaccid paralysis in children. Mycoplasma pneumoniae is a frequent antecedent infection in pediatric GBS and has been associated with a severe, rapidly progressive course with heterogeneous neurologic …

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Postvaccination Immunogenicity Among Pediatric Solid Organ Transplant Recipients

Amy G. Feldman, Brenda L. Beaty, Jose Ferrolino, Gabriela Marón et autres

This cohort study assesses the protection provided by live attenuated viral vaccines among a pediatric population of solid organ transplant recipients 1 year after vaccination.

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Posoleucel, an Allogeneic, Off-the-Shelf Multivirus-Specific T-Cell Therapy, for the Treatment of Refractory Viral Infections in the Post-HCT Setting

Thomas Pfeiffer, Ifigeneia Tzannou, Meng-Fen Wu, Carlos A. Ramos et autres

PURPOSE: Viral infections are a major cause of morbidity and mortality following allogeneic hematopoietic cell transplantation (allo-HCT). In the absence of safe and effective antiviral treatments, virus-specific T cells have emerged as a promising therapeutic option. Posoleucel is a multivirus-specific T-cell therapy …

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1588. Epidemiology of Chronic High Level (CHL) Epstein-Barr virus (EBV) DNAemia in Pediatric Solid Organ Transplant Recipients (SOTR) at Texas Children’s Hospital (TCH)

Kristen G. Valencia Deray, Kathleen Hosek, Daniel Ruderfer, Leanne M Buffaloe et autres

Abstract Background EBV infections cause significant morbidity and mortality in pediatric SOTR and can be complicated by post-transplant lymphoproliferative disorder (PTLD). Contemporary data on CHL EBV DNAemia and the development of PTLD are limited. Methods A retrospective cohort study of patients ≤ …

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1096. Riding the Waves: Infection by SARS-CoV-2 Variants in Solid Organ Transplant Recipients at Texas Children’s Hospital

Leanne M Buffaloe, Claire Bocchini, Elizabeth A. Moulton, Daniel Ruderfer et autres

Abstract Background Texas Children’s Hospital is the largest pediatric solid organ transplant (SOT) program in the US, performing heart, kidney, liver, and lung transplants. Limited data exist about SARS-CoV-2 infection (COVID-19) in the pediatric SOT population. We evaluated the impact of different …

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Necrotizing enterovirus myositis in a pediatric renal transplant recipient

Kristen G. Valencia Deray, Margaret Taylor, Melissa M. Blessing, Claire Bocchini et autres

BACKGROUND: Enteroviruses can cause severe infections, including viral myocarditis, meningitis, acute flaccid myelitis, and viral myositis. METHODS/RESULTS: We report a 3-year-old female renal transplant recipient who presented to a tertiary care hospital with elevated serum liver aminotransferases and subsequently developed proximal muscle …

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276. SARS-CoV-2 Infection in Solid Organ Transplant Candidates and Recipients at Texas Children’s Hospital: A Retrospective Review

Leanne M. Petters, Flor M. Muñoz, Claire Bocchini, Elizabeth A. Moulton et autres

Abstract Background Texas Children’s Hospital (TCH) is the largest pediatric solid organ transplant (SOT) program in the US, performing heart, kidney, liver, and lung transplants. Limited data exists about SARS-CoV-2 infection (COVID-19) in the pediatric SOT populations. We evaluated the impact of …

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946. Epidemiology and Long-term Outcomes of BK Polyomavirus Nephropathy in Kidney Solid Organ Transplant Recipients at Texas Children’s Hospital

Kristen Valencia Deray, Kathleen Hosek, Daniel Ruderfer, Sarah J. Swartz et autres

Abstract Background BK Polyomavirus (BKPyV) is an important cause of graft dysfunction and premature graft failure in pediatric kidney transplant recipients (PKTR). Contemporary data on BK viral associated nephropathy (BKVAN) in PKTR are limited. We sought to determine the frequency, associations with, …

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Allogeneic, Off-the-Shelf Multi-Virus Specific T-Lymphocytes for the Treatment of Virus-Associated Hemorrhagic Cystitis in the Post-HSCT Setting

Thomas Pfeiffer, Ifigeneia Tzannou, Daniel Ruderfer, Swati Naik et autres

BK Virus Epidemiology, Risk Factors, and Clinical Outcomes: An Analysis of Hematopoietic Stem Cell Transplant Patients at Texas Children’s Hospital

Daniel Ruderfer, Meng-Fen Wu, Tao Wang, Poyyapakkam Srivaths et autres

BACKGROUND: BK virus-associated hemorrhagic cystitis (BKV-HC) is a serious complication after hematopoietic stem cell transplantation (HSCT). METHODS: A retrospective review was performed to determine the frequency of BKV-HC and identify risk factors and renal morbidity associated with BKV-HC in pediatric HSCT recipients …

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2305. Staphylococcus aureus Screening and Decolonization for Pediatric Patients Undergoing Cardiovascular Surgery at Texas Children’s Hospital (TCH): A Trainee Quality Improvement Initiative

Catherine Foster, Daniel Ruderfer, Gabriella S Lamb, Juri Boguniewicz et autres

Colonization with Staphylococcus aureus increases the risk of developing healthcare-associated infections (HAIs) in adults, but its role in pediatrics remains unclear. We hypothesized that use of a S. aureus screening and decolonization protocol for pediatric patients undergoing cardiovascular (CV) surgery would result …

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BK Virus Epidemiology, Risk Factors & Outcomes: A Retrospective Analysis of Hematopoietic Stem Cell Transplant (HSCT) Patients at Texas Children’s Hospital (TCH)

Daniel Ruderfer