Mark Rafferty

Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial

Lise J Estcourt, Zoe McQuilten, Peter Bardy, Merrole Cole‐Sinclair et autres

PB0826 Examining Plasma von Willebrand Factor (VWF) Thresholds to Reduce Repeated VWF Testing in Adults

B. Dillon, Mark Rafferty, Sheila M. Brady, Mittie K. Doyle et autres

Low Incidence of COVID-19 Infection in Patients with Acute Myeloid Leukemia Undergoing Reduced Intensity/Venetoclax Based Treatment: Initial Results of the PACE Prospective Clinical Study from the UK Trials Acceleration Program

Ching Ting Loke, Charlotte Gaskell, Sonia Fox, Rachel Fletcher et autres

Abstract The impact of Coronavirus disease 2019 (COVID-19) on outcomes in patients with cancer remains unclear. Acute Myeloid Leukemia (AML)/high-risk myelodysplasia (MDS) are common hematological malignancies resulting in profound immunosuppression, which is exacerbated by intensive and less-intensive chemotherapy. Importantly, venetoclax based regimens …

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AB124. SOH21AS106. Balloon dilatation of subglottic stenosis related to granulomatosis with polyangiitis-long term follow up of four patients and their outcomes

Natalija Snovak, Mark Rafferty, Lisa O’Byrne

Background: Subglottic stenosis is a well-known potentially life-threatening presentation of granulomatosis with polyangiitis (GPA). Circumferential scarring and critical narrowing of the airway at the level of cricoid cartilage and/or upper tracheal rings appears in 10–16% of patients with GPA. Symptoms range from …

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Outcomes of older patients with primary central nervous system lymphoma treated in routine clinical practice in the UK: methotrexate dose intensity correlates with response and survival

Nicolás Martínez‐Calle, Edward Poynton, Alia Alchawaf, Shireen Kassam et autres

Summary Data on older patients with primary central nervous system lymphoma (PCNSL) are scarce. Comorbidities and performance status frequently compromise outcomes in this group. Medical records for consecutive patients ≥65 years (n = 244) with PCNSL diagnosed 2012–2017 from 14 UK centres …

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Real-World Outcomes of Older Patients with Primary Central Nervous System Lymphoma (PCNSL): Methotrexate Dose Intensity and Combination with Cytarabine Correlate with Response and Survival

Nicolás Martínez‐Calle, Edward Poynton, Alia Alchawaf, Shireen Kassam et autres

Abstract INTRODUCTION Primary central nervous system lymphoma (PCNSL) in patients (pts) over 65 years old have poorer outcome compared to younger cohorts, as comorbidities, baseline performance status and susceptibility to iatrogenic toxicity impede adequate drug delivery (Kasenda et al, Ann Oncol, 2015). …

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Hypomegakaryocytic thrombocytopenia and increased number of PNH ‐phenotype cells – an emerging subgroup of myelodysplastic syndrome showing frequent response to immunosuppression

Mark Rafferty, Mike Leach

The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.

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The Modified Graeb Score

Timothy C. Morgan, Jesse Dawson, Danielle Spengler, Kennedy R. Lees et autres

BACKGROUND AND PURPOSE: Simple and rapid measures of intraventricular hemorrhage (IVH) volume are lacking. We developed and validated a modification of the original Graeb scale to facilitate rapid assessment of IVH over time. METHODS: We explored the relationship between the modified Graeb …

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修正Graeb Score: 脳室内出血評価と機能的アウトカム予測を目的として強化されたツール

C Morgan Timothy, Dawson Jesse, Spengler Danielle, Randalynn Kennedy et autres

修正Graeb Score: 脳室内出血評価と機能的アウトカム予測を目的として強化されたツール | 文献情報 | J-GLOBAL 科学技術総合リンクセンター

C Morgan Timothy, Dawson Jesse, Spengler Danielle, Randalynn Kennedy et autres

Anti-Platelet Therapy and Aspirin Resistance – Clinically and Chemically Relevant?

Mark Rafferty, Matthew R. Walters, Jesse Dawson

Platelets play a central role in the pathogenesis of the atherothrombosis which ultimately causes myocardial infarction, stroke and peripheral vascular disease. Commonly used oral anti-platelet drugs include aspirin (an irreversible inhibitor of cyclo-oxygenase), clopidogrel (an ADP receptor antagonist), other thienopyridines such as …

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Neckties and Cerebrovascular Reactivity in Young Healthy Males: A Pilot Randomised Crossover Trial

Mark Rafferty, Terence J. Quinn, Jesse Dawson, James Walters

Background. A necktie may elevate intracranial pressure through compression of venous return. We hypothesised that a tight necktie would deleteriously alter cerebrovascular reactivity. Materials and Methods. A necktie was simulated using bespoke apparatus comprising pneumatic inner-tube with aneroid pressure-gauge. Using a randomised …

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