Cinzia Anna Ventura

PEG-β-Cyclodextrin polymer-based formulation to increase the antiangiogenic activity of rutin in vivo

Federica De Gaetano, Eleftheria Dossi, Anna Cacciola, Noemi Totaro et autres

Rutin (RTN) is a natural flavonoid with well-documented anti-angiogenic, antioxidant, anti-inflammatory, and anti-cancer properties. However, its therapeutic potential is limited by its extremely low water solubility, which results in poor and unpredictable bioavailability. To address these limitations, we developed a new formulation …

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Cyclodextrin-Based Formulations as a Promising Strategy to Overcome the Blood–Brain Barrier: Historical Overview and Prospects in Glioblastoma Treatment

Federica De Gaetano, Noemi Totaro, Cinzia Anna Ventura

Glioblastoma (GB) is one of the most aggressive and treatment-resistant cancers affecting the central nervous system (CNS), predominantly in adults. Despite significant advancements in this field, GB treatment still relies primarily on conventional approaches, including surgical resection, radiotherapy, and chemotherapy, which, due …

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Development, physicochemical characterization and antibacterial evaluation of the baicalin/sulfobutylether-β-cyclodextrin inclusion complex

Giuseppe Paladini, Federica De Gaetano, Valentina Venuti, F. Caridi et autres

The growing spread of antibiotic resistance represents a significant challenge in the medical field, making the treatment of bacterial infections increasingly difficult. Therefore, current research is focused on studying new formulations containing natural antibacterial/antibiofilm agents that can act on both planktonic and …

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The Anti-Angiogenic Effect of Cynara cardunculus L. subsp. cardunculus Waste Product

Adriano Cacciola, Valeria D’Angelo, Federica De Gaetano, Antonella Fais et autres

Cynara cardunculus L. subsp. cardunculus (Cynara cardunculus L. var. sylvestris (Lam.) Fiori), the wild cardoon, is known for its culinary applications and potential health benefits. Due to this, and given the growing interest in circular economies, deepening our under-standing of the effects …

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Morphological and Physicochemical Characterization of Single-Species Bacterial Biofilms Probed by SEM, FTIR-ATR, and µ-Raman Techniques

Giuseppe Paladini, F. Caridi, Domenico Majolino, Valentina Venuti et autres

Treatment of biofilm-related infections represents a major challenge in public health management. Therefore, the accurate identification of both the composition and architecture of bacterial biofilms, in terms of microorganisms and surrounding extracellular polymeric substances (EPSs), represents a fundamental pre-requisite for the rapid …

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Naringenin-Loaded Solid Lipid Nanoparticles: Physical–Chemical Characterization and In Vitro Antibacterial Activity

Federica De Gaetano, F. Caridi, Noemi Totaro, Consuelo Celesti et autres

Currently, problems related to antibiotic resistance are shifting the focus of pharmaceutical research towards natural molecules with antibacterial properties. Among them, flavonoids represent promising molecules with strong antibacterial features; however, they have poor biopharmaceutical properties. In this study, we developed solid lipid …

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Study of Host-Guest Interaction and In Vitro Neuroprotective Potential of Cinnamic Acid/Randomly Methylated β-Cyclodextrin Inclusion Complex

Federica De Gaetano, Loredana Leggio, Consuelo Celesti, Fabio Genovese et autres

Cinnamic acid (CA) has many beneficial effects on human health. However, its poor water solubility (0.23 g/L, at 25 °C) is responsible for its poor bioavailability. This drawback prevents its clinical use. To overcome the solubility limits of this extraordinary natural compound, …

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Randomly methylated β-cyclodextrin improves water – solubility, cellular protection and mucosa permeability of idebenone

Federica De Gaetano, Deborah Mannino, Consuelo Celesti, Maria Bulzomì et autres

Neurodegenerative diseases such as Alzheimer’s are very common today. Idebenone (IDE) is a potent antioxidant with good potential for restoring cerebral efficiency in cases of these and other medical conditions, but a serious drawback for the clinical use of IDE in neurological …

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384P Predictive value of Gal1 and sAxL plasma levels in chemotherapy response of pancreatic ductal adenocarcinoma patients

Laura Visa, Neus Martínez‐Bosch, Cinzia Anna Ventura, Paula Carmona García et autres

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Rutin/Sulfobutylether-β-Cyclodextrin as a Promising Therapeutic Formulation for Ocular Infection

Federica De Gaetano, Martina Pastorello, Venerando Pistarà, Antonio Rescifina et autres

Ocular pathologies present significant challenges to achieving effective therapeutic results due to various anatomical and physiological barriers. Natural products such as flavonoids, alone or in association with allopathic drugs, present many therapeutic actions including anticancer, anti-inflammatory, and antibacterial action. However, their clinical …

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Rutin/Sulfobutylether-β-Cyclodextrin as a Promising Therapeutic Formulation for Ocular Infection

Federica De Gaetano, Martina Pastorello, Venerando Pistarà, Antonio Rescifina et autres

Ocular pathologies present significant challenges in achieving effective therapeutic re-sults due to various anatomical and physiological barriers. Natural products, such as flavonoids, alone or in association with allopathic drugs, present many therapeutical actions, including anti-cancer, anti-inflammatory, and antibacterial action. However, their clinical …

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Characterization and In Vivo Antiangiogenic Activity Evaluation of Morin-Based Cyclodextrin Inclusion Complexes

Federica De Gaetano, Fatima Margani, Vincenzina Barbera, Valeria D’Angelo et autres

Morin (MRN) is a natural compound with antiangiogenic, antioxidant, anti-inflammatory, and anticancer activity. However, it shows a very low water solubility (28 μg/mL) that reduces its oral absorption, making bioavailability low and unpredictable. To improve MRN solubility and positively affect its biological …

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