Felix F. Adams

Incorporating Si into Sb2Se3: Tailoring Optical Phase Change Materials via Nanocomposites

Chih‐Yu Lee, Yi‐Siou Huang, Felix F. Adams, Chuanyu Lian et autres

Chalcogenide-based optical phase change materials (OPCMs) exhibit a large contrast in refractive index when reversibly switched between their stable amorphous and crystalline states. OPCMs have rapidly gained attention due to their versatility as nonvolatile amplitude or phase modulators in various photonic devices. …

Correction: Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia

Arnold Kloos, Konstantinos Mintzas, Lina Winckler, Razif R. Gabdoulline et autres

The article Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia, written by Arnold Kloos, Konstantinos Mintzas, Lina Winckler, Razif Gabdoulline, Yasmine Alwie, Nidhi Jyotsana, Nadine Kattre, Renate Schottmann, Michaela Scherr, Charu Gupta, …

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Reprogramming enriches for somatic cell clones with small-scale mutations in cancer-associated genes

Maike Kosanke, Katarzyna Osetek, Alexandra Haase, Lutz Wiehlmann et autres

Cellular therapies based on induced pluripotent stem cells (iPSCs) come out of age and an increasing number of clinical trials applying iPSC-based transplants are ongoing or in preparation. Recent studies, however, demonstrated a high number of small-scale mutations in iPSCs. Although the …

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Reprogramming enriches for somatic cell clones with small scale mutations in cancer-associated genes

Maike Kosanke, Katarzyna Osetek, Alexandra Haase, Lutz Wiehlmann et autres

Summary Recent studies demonstrated that the mutational load in human induced pluripotent stem cells (hiPSCs) is largely derived from their parental cells, but it is still unknown whether reprogramming may enrich for individual mutations. 30 hiPSC lines were analyzed by whole exome …

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Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia

Arnold Kloos, Konstantinos Mintzas, Lina Winckler, Razif R. Gabdoulline et autres

To establish novel and effective treatment combinations for chronic myelomonocytic leukemia (CMML) preclinically, we hypothesized that supplementation of CMML cells with the human oncogene Meningioma 1 (MN1) promotes expansion and serial transplantability in mice, while maintaining the functional dependencies of these cells …

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Electrode Materials of Sodium-Ion Batteries toward Practical Application

Yangyang Huang, Yuheng Zheng, Xiang Li, Felix F. Adams et autres

Advances in developing affordable batteries are vital for integrating renewable and environmentally friendly energy sources into the power grid. Benefiting from the abundance of sodium resources, sodium-ion batteries (SIBs) have attracted great attention as one of the most promising energy storage and …

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Pooled Generation of Lentiviral Tetracycline-Regulated microRNA Embedded Short Hairpin RNA Libraries

Felix F. Adams, Thomas Walter Hoffmann, Johannes A. Zuber, Dirk Heckl et autres

Short hairpin RNA (shRNA) screens are powerful tools to probe genetic dependencies in loss-of-function studies, such as the identification of therapeutic targets in cancer research. Lentivirally delivered shRNAs embedded in endogenous microRNA contexts (shRNAmiRs) mediate efficient long-term suppression of target genes suitable …

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Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications

Maurice Labuhn, Felix F. Adams, Michelle Shu Wen Ng, Sabine Knoess et autres

Genome editing with the CRISPR-Cas9 system has enabled unprecedented efficacy for reverse genetics and gene correction approaches. While off-target effects have been successfully tackled, the effort to eliminate variability in sgRNA efficacies-which affect experimental sensitivity-is in its infancy. To address this issue, …

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Serially Transplantable Patient-Derived Xenograft Model of Chronic Myelomonocytic Leukemia (CMML)

Arnold Kloos, Felicitas R. Thol, Lina Winckler, Razif R. Gabdoulline et autres

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Targeting Rac-GTPases reverses stroma-induced resistance to notch and mtor-inhibition in T-cell acute lymphoblastic leukemia

Adrian Schwarzer, Felix F. Adams, Martin May, Harald Genth et autres

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The non-coding RNA landscape of human hematopoiesis and leukemia

Adrian Schwarzer, Stephan Emmrich, Franziska Schmidt, Dominik Beck et autres

Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during normal and malignant human hematopoiesis are incompletely understood. Here we present a comprehensive resource defining the non-coding RNA landscape of …

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An optimized lentiviral vector system for conditional RNAi and efficient cloning of microRNA embedded short hairpin RNA libraries

Felix F. Adams, Dirk Heckl, Thomas Walter Hoffmann, Steven Roger Talbot et autres

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