Injoo Hwang

Enhanced trans-cleavage activity using CRISPR-Cas12a variant designed to reduce steric inhibition by cis-cleavage products

Injoo Hwang, Yo Han Song, Sang-Hwa Lee

kr (code pays fourni par la source)

Discovery of 3,7-dimethoxyflavone that inhibits liver fibrosis based on dual mechanisms of antioxidant and inhibitor of activated hepatic stellate cell

Hyomin Park, Eun Ju Lee, Dodam Moon, Hyunji Yun et autres

kr (code pays fourni par la source)

Discovery of 3,7-dimethoxyflavone that inhibits liver fibrosis based on dual mechanisms of antioxidant and inhibitor of activated hepatic stellate cell

Hyomin Park, Eun Ju Lee, Dodam Moon, Areum Cha et autres

kr, Éthiopie (code pays fourni par la source)

Smart gene therapeutics for selective targeting of myofibroblasts derived from hepatic stellate cells and limited expression under inflamed conditions

Dodam Moon, Hyomin Park, Injoo Hwang, Areum Cha et autres

Dear Editor, Recently, we reported the role of transcriptional intermediary factor-1γ (TIF1γ) from hepatic stellate cells (HSCs) in preventing liver fibrosis.1 Therefore, an effective strategy to supply TIF1γ during liver injury offers significant therapeutic promise. Here, we devised a strategy to induce …

kr, Éthiopie, Soudan (code pays fourni par la source)

KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state

Jin Woo Lee, Jin Hur, Yoo‐Wook Kwon, Cheong-Whan Chae et autres

BACKGROUND: Little is known about endogenous inhibitors of angiogenic growth factors. In this study, we identified a novel endogenous anti-angiogenic factor expressed in pericytes and clarified its underlying mechanism and clinical significance. METHODS: Herein, we found Kai1 knockout mice showed significantly enhanced …

kr, pr (code pays fourni par la source)

Discovery of chemerin as the new chemoattractant of human mesenchymal stem cells

Irene Kim, Hyomin Park, Injoo Hwang, Dodam Moon et autres

BACKGROUND: The homing capacity of human mesenchymal stem cells (hMSCs) to the injured sites enables systemic administration of hMSCs in clinical practice. In reality, only a small proportion of MSCs are detected in the target tissue, which is a major bottleneck for …

kr, Éthiopie (code pays fourni par la source)

Endothelin-1 enhances the regenerative capability of human bone marrow-derived mesenchymal stem cells in a sciatic nerve injury mouse model

Injoo Hwang, Eun Ju Lee, Hyomin Park, Dodam Moon et autres

kr, pr (code pays fourni par la source)

Retinol from hepatic stellate cells via STRA6 induces lipogenesis on hepatocytes during fibrosis

Injoo Hwang, Eun Ju Lee, Hyomin Park, Dodam Moon et autres

BACKGROUND: Hepatic stellate cells (HSCs) are activated in response to liver injury with TIF1γ-suppression, leading to liver fibrosis. Here, we examined the mechanism how reduction of TIF1γ in HSCs induces damage on hepatocytes and liver fibrosis. METHOD: Lrat:Cas9-ERT2:sgTif1γ mice were treated Tamoxifen …

kr, Éthiopie (code pays fourni par la source)

Hepatic stellate cell–specific knockout of transcriptional intermediary factor 1γ aggravates liver fibrosis

Eun Ju Lee, Injoo Hwang, Ji Yeon Lee, Jong Nam Park et autres

Transforming growth factor β (TGFβ) is a crucial factor in fibrosis, and transcriptional intermediary factor 1γ (TIF1γ) is a negative regulator of the TGFβ pathway; however, its role in liver fibrosis is unknown. In this study, mesenchymal stem cells derived from human …

kr (code pays fourni par la source)

The MicroRNA-92a/Sp1/MyoD Axis Regulates Hypoxic Stimulation of Myogenic Lineage Differentiation in Mouse Embryonic Stem Cells

Seo Yeon Lee, Jimin Yang, Jung Hwa Park, Hwa Kyoung Shin et autres

Hypoxic microenvironments exist in developing embryonic tissues and determine stem cell fate. We previously demonstrated that hypoxic priming plays roles in lineage commitment of embryonic stem cells. In the present study, we found that hypoxia-primed embryoid bodies (Hyp-EBs) efficiently differentiate into the …

kr, ca (code pays fourni par la source)

Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation

Young Chan Kim, Sang Eun Lee, Somi K. Kim, Hyunduk Jang et autres

kr, pr (code pays fourni par la source)

Endothelin-1 Augments Therapeutic Potency of Human Mesenchymal Stem Cells via CDH2 and VEGF Signaling

Eun Ju Lee, Injoo Hwang, Gi-Hwan Kim, Dodam Moon et autres

In our previous study, we identified differences in the levels of CDH2 and vascular endothelial growth factor (VEGF) between effective and ineffective clones of human umbilical cord blood (hUCB) mesenchymal stem cells (MSCs), with regard to the infarcted rat myocardium. In this …

kr, fr (code pays fourni par la source)