P. Simpson

Adaptive Integration of Heterogeneous Foundation Models to Find Histologically Predictable Genes in Breast Cancer

Hao N. Nguyen, Chaoyi Li, Can Peng, P. Simpson et autres

Abstract Foundation models for computational pathology have rapidly emerged as powerful tools for extracting rich biological and morphological representations from histopathology images. However, variations in model architecture, pre-training data, and optimization objectives often lead to task-dependent performance, rather than universal generalization. As …

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Abstract P1-07-08: Mixed ductal-lobular carcinomas of the breast: Abrogated cell adhesion in the clonal evolution from ductal to lobular morphology

AE McCart Reed, JR Kutasovic, Kátia Nones, L da Silva et autres

Abstract Mixed ductal-lobular carcinomas (MDL) display both ductal and lobular morphology, and are a clear example of intratumour morphological heterogeneity. The evolution of MDL carcinomas is not well understood. There is a paucity of data surrounding the genetic origin of the different …

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Abstract P1-05-16: An integrated molecular analysis of invasive lobular carcinoma

Samir Lal, AE McCart Reed, Kátia Nones, Leesa F. Wockner et autres

Abstract Background: Invasive lobular carcinoma (ILC) is the most commonly diagnosed special histological type of breast cancer, accounting for up to 15% of all cases. Accumulating data suggests the biology and clinical features of ILC differ to those of the more commonly …

au (code pays fourni par la source)

Flat epithelial atypia

Stuart J. Schnitt, Laura C. Collins, Sunil R. Lakhani, P. Simpson

Role of breast screening for characterising the heterogeneity of invasive lobular carcinomas of the breast

AC Vargas, P. Simpson, Janani Jayanthan, Audra Lane et autres

Is there molecular evidence for progression of microglandular adenosis to carcinoma: Results of comparative genomic hybridization (CGH) on microdissected lesions

S. J. Shin, P. Simpson, L. Da Silva, J. Mahalinga-Iyer et autres

Evidence of evolution and intrinsic molecular relationship in a spectrum of morphological variants of invasive lobular carcinoma with variable E-cadherin status

L. Da Silva, Suzanne Parry, Patricia Keith, Sunil R. Lakhani et autres