Accès ouvert
2026
article
OpenAlex
Forough Jahandideh, MengQi Zhang, Hannah Laquerre, Partha Patel et autres
Abstract Objectives To examine the effect of biological sex on mortality, inflammation, organ dysfunction, and bacterial burden in preclinical sepsis models. Data sources MEDLINE and Embase from January 1, 2011, to May 13, 2025. Study selection We included in vivo animal models …
ca
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Jennie Vu, Cory S. Wagg, Claudia D. Holody, Anson Wong et autres
Abstract Sepsis-induced cardiac dysfunction (SICD) occurs in nearly half of septic patients, is associated with increased mortality, and lacks targeted therapy. Emerging evidence implicates impaired mitochondrial function and metabolic inflexibility as central contributors to myocardial depression. Here, we characterized SICD in a …
ca
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Forough Jahandideh, Si Ning Liu, Kimberly B. Tworek, Ronan Noble et autres
Abstract Background Neonatal sepsis is a major cause of infant morbidity and mortality worldwide, particularly in preterm and very low birthweight babies. Fundamental differences between neonates and adults warrant clinically relevant models of neonatal sepsis. Here, we describe a preclinical fecal-slurry (FS)-induced …
ca
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Forough Jahandideh, Asher A. Mendelson, Patricia C. Liaw, Sean E. Gill et autres
Background: Sepsis remains a leading cause of mortality in critical care. Despite extensive preclinical research on sepsis pathophysiology, the development of effective therapies has been largely unsuccessful. Key obstacles include limited construct validity of animal models, insufficient methodological rigor and the lack …
ca, us
(code pays fourni par la source)
Accès ouvert
2026
peer-review
OpenAlex
Forough Jahandideh, Asher A. Mendelson, Patricia C. Liaw, Sean E. Gill et autres
Background Sepsis remains a leading cause of mortality in critical care. Despite extensive preclinical research on sepsis pathophysiology, the development of effective therapies has been largely unsuccessful. Key obstacles include limited construct validity of animal models, insufficient methodological rigor and the lack …
ca
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Braedon McDonald, Kashimbi Mbuta, Onon Batnyam, Ian-Ling Yu et autres
Background Sepsis remains a leading cause of mortality in critical care. Despite extensive preclinical research on sepsis pathophysiology, the development of effective therapies has been largely unsuccessful. Key obstacles include limited construct validity of animal models, insufficient methodological rigor and the lack …
ca
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Alexandra Troitskaya, Aminmohamed Manji, Onon Batnyam, Eric K. Patterson et autres
ABSTRACT Sepsis is defined as a dysregulated response to infection, leading to life-threatening organ dysfunction that particularly affects parenchymal organs. Clinical studies remain inconclusive regarding the impact of biological sex on sepsis, and preclinical studies are predominantly performed in male animals. We …
ca
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Forough Jahandideh, Asher A. Mendelson, Patricia C. Liaw, SE Gill et autres
Background Sepsis remains a leading cause of mortality in critical care. Despite extensive preclinical research on sepsis pathophysiology, the development of effective therapies has been largely unsuccessful. Key obstacles include limited construct validity of animal models, insufficient methodological rigor and the lack …
ca, us
(code pays fourni par la source)
Accès ouvert
2025
peer-review
OpenAlex
Forough Jahandideh, Asher A. Mendelson, Patricia C. Liaw, Sean E. Gill et autres
Background Sepsis remains a leading cause of mortality in critical care. Despite extensive preclinical research on sepsis pathophysiology, the development of effective therapies has been largely unsuccessful. Key obstacles include limited construct validity of animal models, insufficient methodological rigor and the lack …
ca
(code pays fourni par la source)
Accès ouvert
2025
peer-review
OpenAlex
Forough Jahandideh, Asher A. Mendelson, Patricia C. Liaw, Sean E. Gill et autres
Background Sepsis remains a leading cause of mortality in critical care. Despite extensive preclinical research on sepsis pathophysiology, the development of effective therapies has been largely unsuccessful. Key obstacles include limited construct validity of animal models, insufficient methodological rigor and the lack …
ca
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Madison Foster, Dean A. Fergusson, Emily Thompson, Victoria T. Hunniford et autres
Patient engagement in research enriches study design, conduct, and dissemination by integrating lived experiences of patients into the research process. Although patient engagement is becoming more popular in clinical research settings, it remains comparatively rare in preclinical (i.e. laboratory based) research. To …
ca
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Madison Foster, Dean A. Fergusson, Emily Thompson, Victoria T. Hunniford et autres
Abstract Background Patient engagement in research enriches study design, conduct, and dissemination by integrating lived experiences of patients into the research process. Although patient engagement is increasingly common in clinical research settings, it remains rare in preclinical (i.e. laboratory based) research. To …
ca, mx
(code pays fourni par la source)