Asher A. Mendelson

Standardized Single-Session Cardiopulmonary Exercise Test for Measuring Peak Oxygen Uptake, Oxygen On/Off Kinetics, and Skeletal Muscle Oxygenation in ICU Survivors—ICU Combined Assessment of Cardiorespiratory Exercise (ICU-CARE) Study: Protocol for a Cross-Sectional Observational Study

Britney Blunderfield, Jefferson Santana, Raju Majumdar, Isuru Herath et autres

Background: Intensive care unit-acquired weakness (ICU-AW) research focuses predominantly on intrinsic muscle pathology rather than integrated systemic interactions, which are commonly studied in exercise science. Peak oxygen uptake (V˙O2peak), V˙O2 on/off kinetics, and skeletal muscle oxygenation provide a quantitative evaluation of exercise …

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Assessing the effects of fluids and antibiotics in an acute murine model of sepsis: study protocol for the National Preclinical Sepsis Platform-01 (NPSP-01) Study

Forough Jahandideh, Asher A. Mendelson, Patricia C. Liaw, Sean E. Gill et autres

Background: Sepsis remains a leading cause of mortality in critical care. Despite extensive preclinical research on sepsis pathophysiology, the development of effective therapies has been largely unsuccessful. Key obstacles include limited construct validity of animal models, insufficient methodological rigor and the lack …

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Assessing the effects of fluids and antibiotics in an acute murine model of sepsis: study protocol for the National Preclinical Sepsis Platform-01 (NPSP-01) Study [version 3; peer review: 2 approved]

Braedon McDonald, Kashimbi Mbuta, Onon Batnyam, Ian-Ling Yu et autres

Background Sepsis remains a leading cause of mortality in critical care. Despite extensive preclinical research on sepsis pathophysiology, the development of effective therapies has been largely unsuccessful. Key obstacles include limited construct validity of animal models, insufficient methodological rigor and the lack …

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Safety of intravascular administration of umbilical-cord-derived mesenchymal stromal cells: an updated systematic review and meta-analysis

Christine Hum, Jessica Poliwoda, Manoj Lalu, Duncan J Stewart et autres

BACKGROUND: Mesenchymal stromal cells (MSCs) have the capacity to self-renew and exert immunomodulatory and paracrine effects. Our previously published systematic review of 55 randomized controlled trials (RCTs) of all MSC sources found an overall favorable safety profile for MSCs aside from more …

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Protocol for Standardized Single-Session Cardiopulmonary Exercise Test for Measuring Peak Oxygen Uptake, Oxygen On/Off Kinetics, and Skeletal Muscle Oxygenation in ICU survivors: ICU Combined Assessment of Cardio-Respiratory Exercise (ICU-CARE) Study (Preprint)

Britney Blunderfield, Jefferson Silva de SANTANA, Raju Majumdar, Isuru Herath et autres

BACKGROUND ICU-acquired weakness (ICU-AW) research focuses predominantly on intrinsic muscle pathology rather than integrated systemic interactions, commonly studied in exercise science. Peak oxygen uptake (V ̇O_2peak), V ̇O_2 on/off kinetics, and skeletal muscle oxygenation provide quantitative evaluation of exercise capacity, and are …

Assessing the effects of fluids and antibiotics in an acute murine model of sepsis: study protocol for the National Preclinical Sepsis Platform-01 (NPSP-01) Study

Forough Jahandideh, Asher A. Mendelson, P. C. Liaw, SE Gill et autres

Background Sepsis remains a leading cause of mortality in critical care. Despite extensive preclinical research on sepsis pathophysiology, the development of effective therapies has been largely unsuccessful. Key obstacles include limited construct validity of animal models, insufficient methodological rigor and the lack …

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Protocol for multi-organ isolation of murine leukocytes for flow cytometry

Paul Jerard Layug, Agata Marcinow, David Sontag, Asher A. Mendelson et autres

The immune system comprises several specialized cells across multiple organs. Here, we present a protocol for the isolation of leukocytes from murine blood, spleen, mesenteric lymph nodes, liver, kidney, and skeletal muscle. We describe steps for cell isolation and gradient density separation …

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Identifying challenges and enablers to engaging patients in preclinical laboratory research: an interview study

Madison Foster, Dean A. Fergusson, Emily Thompson, Victoria T. Hunniford et autres

Patient engagement in research enriches study design, conduct, and dissemination by integrating lived experiences of patients into the research process. Although patient engagement is becoming more popular in clinical research settings, it remains comparatively rare in preclinical (i.e. laboratory based) research. To …

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Inflation of the journal impact factor

Jennifer Ziegler, Barret N. M. Rush, Asher A. Mendelson, Sylvain Lother et autres

In 1975, the inaugural Journal Citation Reports (JCR) included the widely used bibliometric measure, the journal impact factor (JIF). The JIF is now reported in the annual JCR by Clarivate Analytics. It is calculated by dividing the number of current year citations …

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Identifying Challenges and Enablers to Engaging Patients in Preclinical Laboratory Research

Madison Foster, Dean A. Fergusson, Emily Thompson, Victoria T. Hunniford et autres

Abstract Background Patient engagement in research enriches study design, conduct, and dissemination by integrating lived experiences of patients into the research process. Although patient engagement is increasingly common in clinical research settings, it remains rare in preclinical (i.e. laboratory based) research. To …

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Impact of streptozotocin-induced hyperglycemia on the host response to sepsis

Sean Carlin, Dhruva J. Dwivedi, Erblin Cani, Neha Sharma et autres

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Effects of anesthesia modality on plasma proteomics and biomarkers of inflammation and vascular injury: an exploratory analysis

Nathan Wiebe, Victor Spicer, David Sontag, Ying Lao et autres

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