Gaik Lin Ong

Effects of the Gelatin Plasma Substitutes Haemaccel ® , Plasmagel ® and Plasmion ® (Geloplasma ® ) on Collagen-, ADP- and Adrenaline-Induced Aggregation of Human Platelets in vitro

J. Stibbe, Pascal Plas, Gaik Lin Ong, F. ten Hoor et autres

The effect of some gelatin plasma substitutes (Haemaccel, plasmagel and Plasmion (Geloplasma), which are widely used in Europe) on collagen-, ADP- and adrenaline-induced platelet aggregation in human PRP in vitro was studied under controlled conditions (pH, electrolyte composition). Haemaccel inhibited these aggregations, …

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Influence of Prostaglandin E 1 on Platelet Decrease in the Heart-Lung Machine

J. Stibbe, Gaik Lin Ong, F. ten Hoor, Joske Nauta et autres

It was investigated whether the decrease of platelet count, which occurs during open heart surgery with the use of the heart-lung machine (HLM), is a result of platelet adhesion and/or aggregation. PGE1 in concentrations of 100, 10 and 5 ng/ml, respectively, inhibited …

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Single-cell cytotoxicity with radiolabeled antibodies.

Gaik Lin Ong, Sammy Elsamra, David M. Goldenberg, M. Jules Mattes

Previous studies demonstrated the effective, antigen-specific killing of Raji B-lymphoma cells in vitro by radiolabeled anti-CD74, attributable largely to the high level of uptake, of approximately 10(7) antibody (Ab) molecules/cell/ day. This Ab is rapidly delivered to lysosomes for catabolism, so the …

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Radionuclides linked to a CD74 antibody as therapeutic agents for B-cell lymphoma: comparison of Auger electron emitters with beta-particle emitters.

Serengulam V. Govindan, David M. Goldenberg, Sammy Elsamra, Gary L. Griffiths et autres

UNLABELLED: We demonstrated previously that human B-cell lymphomas were effectively and specifically killed in vitro by an antibody to CD74 (LL1) linked to (111)In or other Auger electron emitters. This study was intended to more accurately compare the potency and specificity of …

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Localization of an antibody to CD74 (MHC class II invariant chain) to human B cell lymphoma xenografts in nude mice

Lisa B. Shih, Gaik Lin Ong, J. D. Burton, Dina Mishina et autres

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Limitations in the use of low pH extraction to distinguish internalized from cell surface-bound radiolabeled antibody

Gaik Lin Ong, M. Jules Mattes

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Processing of antibodies to the MHC class II antigen by B-cell lymphomas: release of Fab-like fragments into the medium

Gaik Lin Ong, M. Jules Mattes

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Enhancement of tumor-to-nontumor localization ratios by hepatocyte-directed blood clearance of antibodies labeled with certain residualizing radiolabels.

Supriya Patel, Rhona Stein, Gaik Lin Ong, David M. Goldenberg et autres

UNLABELLED: To increase tumor-to-nontumor localization ratios of injected radiolabeled antibodies (Abs), several interrelated methods were used. METHODS: The model systems used were two human carcinoma xenografts grown in nude mice, targeted by antibodies RS11 (antiepithelial glycoprotein-2) or MN-14 (anticarcinoembryonic antigen). The Abs …

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Cytotoxicity with Auger electron-emitting radionuclides delivered by antibodies

Gary L. Griffiths, Serengulam V. Govindan, George Sgouros, Gaik Lin Ong et autres

We investigated the in vitro cytotoxic potential of Auger electron-emitting radionuclides delivered to the cytoplasm or, more specifically, to lysosomes, via antibodies. The antibody (Ab) used was LL1, which is specific for CD74, an epitope of the major histocompatibility complex (MHC) class …

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Cytotoxicity with Auger electron-emitting radionuclides delivered by antibodies

Gary L. Griffiths, Serengulam V. Govindan, George Sgouros, Gaik Lin Ong et autres

Intracellular processing of 99Tcm-antibody conjugates

Habibe Karacay, Gaik Lin Ong, H. J. Hansen, Gary L. Griffiths et autres

The catabolism of 99Tcm-antibody conjugates after internalization by B-cell lymphomas was investigated, using antibody LL1, an antibody to the MHC class II invariant chain which is internalized and catabolized very rapidly. Intact IgG antibodies were labelled with 99Tcm after mild reduction. The …

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The processing of antibodies bound to B-cell lymphomas: The effect of inadvertent mycoplasma contamination

Gaik Lin Ong, M. Jules Mattes

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