Caroline Reynolds

O44 Raising awareness of medical emergencies in eating disorders: a quality improvement project

Dom Maxfield, Emer Kennedy, Marina Politis, Christie Mellor et autres

Introduction Eating disorders (ED) are complex psychiatric illnesses and can be associated with high mortality rates, due to complications of malnutrition.1 The Medical Emergencies in Eating Disorders (MEED) guidelines support early recognition of these life-threatening medical complications.2 An initial audit within our …

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Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension

Akshay S. Desai, Adam Karns, Jolita Badarienė, Ahmad Aswad et autres

Importance: In prior monotherapy studies of patients with hypertension, single subcutaneous doses of zilebesiran, an investigational RNA interference therapeutic, reduced serum angiotensinogen levels and systolic blood pressure (SBP) at 3 and 6 months. Objective: To evaluate the efficacy and safety of zilebesiran …

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ESCAPE-CS-Explore: Barriers and Enablers to Quality Cardiogenic Shock Care: A Focus Group Study

S William, Sabine Allida, Mark Dennis, Pankaj Jain et autres

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RNA Interference With Zilebesiran for Mild to Moderate Hypertension

George L. Bakris, Manish Saxena, Anil Gupta, Fadi Chalhoub et autres

Importance: Angiotensinogen is the most upstream precursor of the renin-angiotensin-aldosterone system, a key pathway in blood pressure (BP) regulation. Zilebesiran, an investigational RNA interference therapeutic, targets hepatic angiotensinogen synthesis. Objective: To evaluate antihypertensive efficacy and safety of different zilebesiran dosing regimens. Design, …

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Impact of clinicians’ behavior, an educational intervention with mandated blood pressure and the hypotension prediction index software on intraoperative hypotension: a mixed methods study

Ilonka N. de Keijzer, Jaap Jan Vos, David Yates, Caroline Reynolds et autres

PURPOSE: Intraoperative hypotension (IOH) is associated with adverse outcomes. We therefore explored beliefs regarding IOH and barriers to its treatment. Secondarily, we assessed if an educational intervention and mandated mean arterial pressure (MAP), or the implementation of the Hypotension Prediction Index-software (HPI) …

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The early diagnosis of cancer in primary care: A qualitative exploration of the patient's role and acceptable safety‐netting strategies

Jane Heyhoe, Caroline Reynolds, Rebecca Lawton

OBJECTIVES: The study had two aims-to assess the components considered important for patient involvement in diagnosing cancer earlier in primary care and to assess the acceptability, feasibility, cost and burden of three safety-netting interventions in terms of their potential to become a …

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Post-ICU Care: A Qualitative Analysis of Patient Priorities and Implications for Redesign.

Leslie P. Scheunemann, Joel White, Suman Prinjha, Megan Hamm et autres

RATIONALE: While survival during critical illness is improving, little evidence exists to guide post-intensive care unit (ICU) care. Understanding patients' needs and priorities is fundamental to improving care quality. OBJECTIVE: To describe the evolution of patients' priorities for recovery across the spectrum …

Validation of revised patient measures of safety: PMOS-30 and PMOS-10

Gemma Louch, Caroline Reynolds, Sally Moore, Claire Marsh et autres

OBJECTIVES: There is growing evidence that patients can provide feedback on the safety of their care. The 44-item Patient Measure of Safety (PMOS) was developed for this purpose. While valid and reliable, the length of this questionnaire makes it potentially challenging for …

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Developing a safety-netting intervention for the earlier diagnosis of cancer in primary care: the Shared Safety Net Action Plan (SSNAP)

Jane Heyhoe, Caroline Reynolds, Rebecca Lawton

Background Diagnosing cancer earlier broadens treatment options and improves survival outcomes. When symptoms do not indicate a cancer diagnosis referral, evidence suggests patients could play an important role in achieving a faster cancer diagnosis by assisting with symptom follow-up and review. Little …

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THE ROLE OF TWITTER IN THE PROFESSIONAL LEARNING OF IRISH PRIMARY TEACHERS

Caroline Reynolds, Keith Johnston

1 Scoil Bhríde, Croghan, Co. Offaly (IRELAND)2 Trinity College Dublin, the University of Dublin (IRELAND)

Physician attitudes about non-medical switching to biosimilars: results from an online physician survey in the United States

Amanda Teeple, Lorie Ellis, Laura Huff, Caroline Reynolds et autres

OBJECTIVE: This study was designed to understand the level of familiarity of US rheumatologists, gastroenterologists and dermatologists with biosimilar therapies, their experience with non-medical switching (switching medications for reasons unrelated to patient health) of patients between biologics and their attitudes towards switching …

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Patient attitudes about non-medical switching to biosimilars: results from an online patient survey in the United States

Amanda Teeple, Shiphra Ginsburg, Leah Howard, Laura Huff et autres

OBJECTIVE: To evaluate patient attitudes regarding non-medical switching (NMS) to biosimilars among patients with autoimmune disease currently receiving a biologic. METHODS: An online survey was conducted among patients meeting the following criteria: ≥18 years of age; residing in the US; diagnosis of …

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