Adrian M. Piliponsky

Innate Immune Cell and Epithelial Subsets Coordinate Airway Responses to Allergen

Ryan C. Murphy, C López-Martínez, Tristan Kooistra, Y Lai et autres

RATIONALE: The mechanisms responsible for promoting allergic asthma remain incompletely understood, particularly the role of the crosstalk between innate immune cells and airway epithelium in coordinating the response to inhaled allergen. OBJECTIVE: Identify transcriptional responses to allergen exposure in human airway samples …

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Human Rhinovirus A16 Infection of Mast Cells Promotes T2 and Non‐ T2 Immune Responses That Are Modulated by the Airway Epithelium

Ying Lai, Ryan C. Murphy, Matthew Liu, Maciej W. Czarnecki et autres

Respiratory viral infection with major serotype human rhinoviruses (RVs) such as RV A16 (RV16) serves as a common trigger for acute asthma exacerbations and can generate a strong type-2 (T2) immune response in the lower airways of some individuals with asthma [1]. …

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Siglec-6 And Siglec-8 Directed Bispecific Antibodies Engaging T Cells Can Deplete Mast Cells

Adrian M. Piliponsky, Madelyn Shapiro, Nyssa Samanas, Raymond Ruff et autres

Human Rhinovirus A16 Infection of Mast Cells Promotes T2 and non-T2 Immune Responses that are Modulated by the Airway Epithelium

Ying Lai, Ryan C. Murphy, Matthew Y. Liu, Maciej W. Czarnecki et autres

IntroductionRespiratory viral infection with major serotype human rhinoviruses (RVs) are implicated in the onset and progression of asthma (1) and serve as a common trigger for acute exacerbations. Major serotype A human RVs such as RV A16 (RV16) ente

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Siglec-9 modulates mast cell function in homeostasis and in mouse models of allergic disease 4222

Josie Sachen, Victoria Puryear, Albert J. Seo, Jake S. Foronda et autres

Abstract Description Mast cell activation is essential in allergic disease development. Engaging Sialic acid-binding immunoglobin-like lectins (Siglecs) such as CD33, Siglec-6, -7 and -8 has been shown to inhibit mast cell activation. We have identified Siglec-9 as a functional Siglec on human …

Mast Cells Are Intrinsically Primed for Degranulation in DOCK8 Deficiency

Nyssa B. Samanas, Irina Miralda, Nadja Van Camp, Josie Sachen et autres

The data that support the findings of this study are available from the corresponding author upon reasonable request. Table S1. Characteristics of DOCK8-deficient patients. Table S2. Proteins that were observed in fetal skin-derived cultured mast cells (FSCMCs) from DOCK8 mutant mice (Dock8pri/pri …

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Attenuated interferon-γ following injury is associated with chronic critical illness

Joseph Cuschieri, Lucy Z. Kornblith, Hashem Kalthoum, Sophia A. Cuschieri et autres

OBJECTIVE: Altered genomic expression of interferon (IFN)-γ has been demonstrated to be associated with the development of organ failure following severe injury. Altered expression of IFN-γ on innate immunity and long-term outcomes have not been previously examined. The purpose of this study …

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Group B Streptococcus Hyaluronidase Promotes Lung Invasion and Early Onset Disease

Sarah J. Clark, Hyung‐Jun Kwon, Joy Twentyman, Nyssa B. Samanas et autres

Abstract Rationale: Group B Streptococcus (GBS) infections pose a significant public health risk leading to preterm births and invasive infections in newborns. Early onset disease (EOD) in infants occurs following the inhalation of infected fluids during birth, which results in neonatal pneumonia …

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The type 2 immune response in gut homeostasis and parasite transmission in malaria

Nora Céspedes, Renée M. Tsolis, Adrian M. Piliponsky, Shirley Luckhart

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Sialic acids from the Group B Streptococcus (GBS) capsule dampen mast cell activation through Siglec-9

Irina Miralda Molina, Austyn Orvis, Michelle C. Coleman, Alyssa Brokaw et autres

Abstract GBS is a leading cause of bacterial infection in newborns, adult diabetics, pregnant women, and the elderly. A key virulence factor of GBS is its surface capsular polysaccharide, which displays terminal sialic acids that suppress host innate immune responses by engaging …

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The injured monocyte: The link to chronic critical illness and mortality following injury

Joseph Cuschieri, Lucy Z. Kornblith, Shibani Pati, Adrian M. Piliponsky

BACKGROUND: This study aimed to understand the altered innate immune response in severely injured patients leading to chronic critical illness (CCI). Specifically, it focused on characterizing the monocyte populations and their correlation with CCI development and long-term complications. METHODS: Over a 3-year …

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Distinct Epithelial-Innate Immune Cell Transcriptional Circuits Underlie Airway Hyperresponsiveness in Asthma

Ryan C. Murphy, Ying Lai, Matthew Y. Liu, Taha Al‐Shaikhly et autres

Abstract Rationale Indirect airway hyperresponsiveness (AHR) is a highly specific feature of asthma, but the underlying mechanisms responsible for driving indirect AHR remain incompletely understood. Objectives To identify differences in gene expression in epithelial brushings obtained from individuals with asthma who were …

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