Ivan E. de Araújo

Isl1 + Central Amygdala Neurons Coordinate Control of the Jaw and Stomach During Ingestion

Matthew H. Perkins, Wenfei Han, Leonardo Santana Novaes, Hao Chang et autres

Abstract Central Amygdala neurons expressing Isl1 (CeA Isl1+ ) project to brainstem regions involved in control of the jaw and the stomach, including the parabrachial nucleus (PBN), the nucleus of the tractus solitary (NTS), and the parvocellular reticular nucleus (PCRt). Stimulation of …

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Selection and transmission of the gut microbiome alone can shift mammalian behavior

Taichi A. Suzuki, Akbuğa-Schön Tanja, Jillian L. Waters, Dennis Jakob et autres

Animals live in partnership with their gut microbiota, and these microbial communities often shift when hosts adapt to new environments. While it is well known that the microbiome can influence traits ranging from metabolism to behavior, a key question remains unresolved: can …

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Selection and transmission of the gut microbiome alone shifts mammalian behavior

Taichi A. Suzuki, Tanja Akbuğa-Schön, Jillian L. Waters, Dennis Jakob et autres

Abstract Natural selection acts on phenotypic variation, which is influenced by genetic and environmental factors including the microbiome. Whether microbiome-mediated host phenotypes can be selected and transmitted remains untested in vertebrates. Here, we first identified locomotor activity as a trait transmissible through …

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D1 and D2 neurons in the nucleus accumbens enable positive and negative control over sugar intake in mice

Rafael Sandoval-Rodríguez, Jenifer Alejandra Parra-Reyes, Wenfei Han, Pavel E. Rueda‐Orozco et autres

Stress-sensitive neural circuits change the gut microbiome via duodenal glands

Hao Chang, Matthew H. Perkins, Leonardo Santana Novaes, Qian Feng et autres

Negative psychological states impact immunity by altering the gut microbiome. However, the relationship between brain states and microbiome composition remains unclear. We show that Brunner's glands in the duodenum couple stress-sensitive brain circuits to bacterial homeostasis. Brunner's glands mediated the enrichment of …

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An Amygdalar-Vagal-Glandular Circuit Controls the Intestinal Microbiome

Hao Chang, Matthew H. Perkins, Leonardo Santana Novaes, Qian Feng et autres

Psychological states can regulate intestinal mucosal immunity by altering the gut microbiome. However, the link between the brain and microbiome composition remains elusive. We show that Brunner’s glands in the duodenal submucosa couple brain activity to intestinal bacterial homeostasis. Brunner’s glands mediated …

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Stress-activated brain-gut circuits disrupt intestinal barrier integrity and social behaviour

Scott J. Russo, Kenny L. Chan, Long Li, Lyonna F. Parise et autres

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The Neurobiology of Eating Behavior in Obesity: Mechanisms and Therapeutic Targets: A Report from the 23rd Annual Harvard Nutrition Obesity Symposium

Imen Becetti, Esther L Bwenyi, Ivan E. de Araújo, Jamy D. Ard et autres

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D1 and D2 neurons in the nucleus accumbens enable positive and negative control over sugar intake in mice

Rafael Sandoval-Rodríguez, Jenifer Alejandra Parra-Reyes, Wenfei Han, Pavel E. Rueda‐Orozco et autres

Although the consumption of carbohydrates is needed for survival, their potent reinforcing properties drive obesity worldwide. In turn, sugar overconsumption reveals a major role for brain reward systems in regulating sugar intake. However, it remains elusive how different cell types within the …

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Identification of central amygdala and trigeminal motor nucleus connectivity in humans: An ultra‐high field diffusion MRI study

Batu Kaya, Paul Geha, Ivan E. de Araújo, Iacopo Cioffi et autres

The neuroanatomical circuitry of jaw muscles has been mostly explored in non-human animals. A recent rodent study revealed a novel circuit from the central amygdala (CeA) to the trigeminal motor nucleus (5M), which controls biting attacks. This circuit has yet to be …

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An inter-organ neural circuit for appetite suppression

Tong Zhang, Matthew H. Perkins, Hao Chang, Wenfei Han et autres

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Chronic pain precedes disrupted eating behavior in low-back pain patients

Yezhe Lin, Ivan E. de Araújo, G.L. Stanley, Dana Melanie Small et autres

Chronic pain is associated with anhedonia and decreased motivation. These behavioral alterations have been linked to alterations in the limbic brain and could explain the increased risk for obesity in pain patients. The mechanism of these behavioral changes and how they set …

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