Bertrand Accart

Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau seeding in Alzheimer's disease

Marie Oosterlynck, Laura Fichter, Élodie Leroux, Sabiha Eddarkaoui et autres

BACKGROUND: Tauopathies are neurodegenerative diseases all characterized by tau lesions in the brain. Nevertheless, a clinical and pathophysiological heterogeneity is present among them. This includes the dominant tau isoform found within aggregates (3R and/or 4R tau) along with different brain regions being …

fr (code pays fourni par la source)

Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau seeding in Alzheimer's disease

Marie Oosterlynck, Laura Fichter, Élodie Leroux, Sabiha Eddarkaoui et autres

Abstract Background Tauopathies are neurodegenerative diseases all characterized by tau lesions in the brain. Nevertheless, a clinical and pathophysiological heterogeneity is present among them. This includes the dominant tau isoform found within aggregates (3R and/or 4R tau) along with different brain regions …

fr (code pays fourni par la source)

Additional file 1 of Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau seeding in Alzheimer's disease

Marie Oosterlynck, Laura Fichter, Élodie Leroux, Sabiha Eddarkaoui et autres

Additional file 1.

fr (code pays fourni par la source)

Additional file 1 of Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau seeding in Alzheimer's disease

Marie Oosterlynck, Laura Fichter, Élodie Leroux, Sabiha Eddarkaoui et autres

Additional file 1.

fr (code pays fourni par la source)

Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau seeding in Alzheimer's disease

Marie Oosterlynck, Laura Fichter, Élodie Leroux, Sabiha Eddarkaoui et autres

Abstract Background Tauopathies are neurodegenerative diseases all characterized by tau lesions in the brain. Nevertheless, a clinical and pathophysiological heterogeneity is present among them. This includes the dominant tau isoform found within aggregates (3R and/or 4R tau) along with different brain regions …

fr (code pays fourni par la source)

Stratification of brain-derived extracellular vesicles of Alzheimer’s disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles

Marie Oosterlynck, Élodie Leroux, Balasubramaniam Namasivayam, Thomas Bouillet et autres

BACKGROUND: Alzheimer's disease (AD) is the most prominent form of dementia worldwide. It is characterized by tau lesions that spread throughout the brain in a spatio-temporal manner. This has led to the prion-like propagation hypothesis implicating a transfer of pathological tau seeds …

fr (code pays fourni par la source)

Author Correction: Classification of GBA1 variants and their impact on Parkinson’s disease: an in silico score analysis

Aymeric Lanore, Christelle Tesson, Aymeric Basset, François-Xavier Lejeune et autres

In this article, the ‘Competing interests’ statement was missing and should have been ‘Elena Moro was the Associate Publisher of npj Parkinson’s Disease at the time of publication and was not involved in the peer review or editorial decision for this article. …

fr, us (code pays fourni par la source)

Anti-tau VHH therapy against PHF6: a safe approach to slowing the phenotype of tau pathology

Raphaëlle Caillierez, Clémence Leboullenger, Sarah Leclercq, Mélanie Besegher et autres

BACKGROUND: Tauopathies share common features, including tau aggregation, which plays a central role in neurodegeneration. However, these disorders are highly heterogeneous, particularly in the spread of pathological tau species between cells. In Alzheimer's disease, intracellular tau aggregation is followed by a propagation …

fr (code pays fourni par la source)

Classification of GBA1 variants and their impact on Parkinson’s disease: an in silico score analysis

Aymeric Lanore, Christelle Tesson, Aymeric Basset, François-Xavier Lejeune et autres

Bi-allelic pathogenic GBA1 variants cause Gaucher disease (GD), whereas certain heterozygous missense variants increase the risk of Parkinson's disease (PD), although the underlying mechanisms are unclear. Here, we classified GBA1 missense variants using predictive and structural scores, and analysed their associations with …

fr, us (code pays fourni par la source)

Anti-Tau VHH Therapy Against PHF6: A Safe Approach to Slowing the Phenotype of Tau Pathology

Raphaëlle Caillierez, Clémence Leboullenger, Sarah Leclercq, Mélanie Besegher et autres

fr (code pays fourni par la source)

Stratification of Brain-Derived Extracellular Vesicles of Alzheimer’s Disease Patients Indicates a Unique Proteomic Content and a Higher Seeding Capacity of Small Extracellular Vesicles

Marie Oosterlynck, Élodie Leroux, Balasubramaniam Namasivayam, Thomas Bouillet et autres

fr (code pays fourni par la source)

Serum sortilin-derived propeptide concentrations as markers of depression in chronic stroke

Estelle Mazella, Anne-Marie Mendyk, Bertrand Accart, Marc Borsotto et autres

Post-stroke depression is a common and debilitating consequence of stroke that significantly impacts functional recovery and quality of life. Identifying new biological markers and treatments is essential to enhance patient care. This study aimed to assess the relationship between serum levels of …

fr (code pays fourni par la source)