Gaelen Moore

Human J-domain proteins promote stress granule disassembly and suppress neurodegeneration-linked protein aggregation

Giovanni J. Mastromarco, Rebecca Earnshaw, Gaelen Moore, X.Y. Sherwin Xu et autres

Stress granules are conserved biomolecular condensates that form under stress and rapidly disassemble during recovery. Stress granules have been linked to pathological protein aggregation and their impaired disassembly reduces cell viability, yet the mechanisms governing their clearance and protein aggregation remain unclear. …

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RanBP2-dependent SUMOylation of G3BP2 inhibits formation, and promotes disassembly, of stress granules

Yifan E. Wang, Javid Guliyev, Sean SJ Ihn, Gaelen Moore et autres

Stress granules and processing bodies (P-bodies) are dynamic cytoplasmic ribonucleoprotein (RNP) condensates that coordinate translation inhibition, mRNA storage, and decay during cellular stress. Emerging evidence suggests that SUMOylation contributes to the regulation of these RNP granules in human cells, though the underlying …

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PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

Christopher Chin Sang, Gaelen Moore, Maria Tereshchenko, Hongshan Zhang et autres

Poly(ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and plays crucial roles in recruiting DNA repair proteins through its activity - poly(ADP-ribosyl)ation (PARylation). The enrichment of DNA repair proteins at sites of DNA damage has been described …

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Author Reply to Peer Reviews of PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

Christopher Chin Sang, Gaelen Moore, Maria Tereshchenko, Hongshan Zhang et autres

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A secreted bacterial protein protects bacteria from cationic antimicrobial peptides by entrapment in phase-separated droplets

Nicholas Ostan, Gregory B. Cole, Flora Zhiqi Wang, Sean E. Reichheld et autres

Abstract Mammalian hosts combat bacterial infections through the production of defensive cationic antimicrobial peptides (CAPs). These immune factors are capable of directly killing bacterial invaders; however, many pathogens have evolved resistance evasion mechanisms such as cell surface modification, CAP sequestration, degradation, or …

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PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

Christopher Chin Sang, Gaelen Moore, Maria Tereshchenko, Michael L. Nosella et autres

ABSTRACT Poly(ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and plays crucial roles in recruiting DNA repair proteins through its activity – poly(ADP-ribosyl)ation (PARylation). The enrichment of DNA repair proteins at sites of DNA damage has been …

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A central chaperone-like role for 14-3-3 proteins in human cells

Dmitri Segal, Stefan Maier, Giovanni J. Mastromarco, Wesley Wei Qian et autres

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Concepts | No Membrane, No Problem: Cellular Organization by Biomolecular Condensates

Christopher Chin Sang, Gaelen Moore, Hyun O. Lee

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TRANSGENIC ADVANCES TOWARD INDUCTION OF PRECOCIOUS FLOWERING IN CITRUS

T.L. Kamps, Gaelen Moore

ISHS XXVIII International Horticultural Congress on Science and Horticulture for People (IHC2010): International Symposium on Genomics and Genetic Transformation of Horticultural Crops TRANSGENIC ADVANCES TOWARD INDUCTION OF PRECOCIOUS FLOWERING IN CITRUS