Hyo‐Il Jung

Proteomic Profiling of Human Extracellular Vesicles Reveals Diagnostic Biomarkers for Colon Adenocarcinoma

Yura Seo, Yoon Dae Han, Linda Bojmar, Kyung‐A Kim et autres

Early detection of colon adenocarcinoma (COAD) remains suboptimal. Fecal tests fail to diagnose 30% of stage I cancer, and serum CEA lacks sensitivity (< 40%). Extracellular vesicles (EVs) circulate systemically and package tumor-related cargo, making them attractive non-invasive biomarkers for cancer diagnosis. …

kr, se, us, il (code pays fourni par la source)

Vertical numbering-up microfluidic architecture for scalable and homogeneous lipid nanoparticle production

Zhaoyu Zhang, J. S. Kim, Jinwoo Hwang, H. K. Seo et autres

wound model. Notably, an 80-cartridge platform is projected to achieve a production flow rate of approximately 80 L per hour, validating this platform as a viable solution for industrial-scale LNP manufacturing.

kr (code pays fourni par la source)

Lab-in-a-cartridge for real-time detection of tuberculosis via precise measurement of urinary lipoarabinomannan

Woong Heo, Qingyang Wang, Seoyeon Choi, Joonchul Shin et autres

Current methods for detecting Mycobacterium tuberculosis (M.tb) in centralized medical facilities are a bottleneck in TB surveillance, particularly in resource-constrained regions. In response, we present a groundbreaking portable bio-tool, the lab-in-a-cartridge (LIC) system, designed for on-site detection of lipoarabinomannan (LAM) in trace …

kr (code pays fourni par la source)

Antibody-based alternatives to animal testing for toxin detection and antitoxin evaluation

Seo-Hyuk Chang, Jieun Jang, Wonjun Yang, Nam-Kyung Lee et autres

Animal experiments have long played a central role in biomedical research and toxicology, yet their limitations in translational accuracy and ethical concerns have intensified the demand for reliable alternatives. Antibody-based technologies are versatile tools used to develop non-animal testing methods capable of …

kr (code pays fourni par la source)

Microfluidic ExoBONE Assay for Predicting Bone Mineral Density Improvement in Primary Hyperparathyroidism

Seunghyun Lee, Sunyoung Park, Namki Hong, Yongnyun Kim et autres

kr (code pays fourni par la source)

Microfluidic Generation of Exosome‐Mimetic Nanoparticles for Scalable Production and Enhanced Therapeutic Efficacy

J. S. Kim, Do Hyun Lee, H. K. Seo, Hyun‐Jin Lee et autres

Exosomes are nanoscale lipid-bilayer vesicles that mediate intercellular communication by delivering bioactive molecules such as nucleic acids and proteins. Among them, exosomes derived from salivary gland epithelial stem cells (sgESC-Exos) exhibit antifibrotic effects in salivary gland models through the delivery of antifibrotic …

kr (code pays fourni par la source)

Machine learning-driven microfluidic deglycosylation for ultra-sensitive detection of PD-L1 extracellular vesicles

Cheng Nie, Hyorim Jeong, Sunyoung Park, Hairi Jiang et autres

kr (code pays fourni par la source)

Critical Challenges and Future Direction in Extracellular Vesicle Research and Commercialization

Hyo‐Il Jung

kr (code pays fourni par la source)

Automatic Identification of CTC in Microscope Images Based on Automatic Detection of Region of Interest and Machine Learning Algorithm

Kazuki Hashimoto, Kouki Tsuji, Seongmin Ha, Hyo‐Il Jung

Currently, cancer is the leading cause of death in the world, and it is estimated that more than 10 million people will die from cancer in 2020. Since cancer progresses by repeated metastasis, early detection and early treatment are necessary. There are …

jp, kr (code pays fourni par la source)

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

Young-Won Kim, Si Hyeon Chae, Dahae Lee, Bum Soo Lee et autres

The efficacy evaluation of anticancer drugs derived from natural products has traditionally relied on animal models, highlighting the need for more efficient preclinical assessment platforms. In this study, a binary tumor-microenvironment-on-a-chip (T-MOC) system is introduced to assess the therapeutic potential of illudin …

kr (code pays fourni par la source)

Artificially intelligent nasal perception for rapid sepsis diagnostics

Joonchul Shin, Gwang Su Kim, Seongmin Ha, Taehee Yoon et autres

Sepsis, a life-threatening disease caused by infection, presents a major global health challenge due to its high morbidity and mortality rates. A rapid and precise diagnosis of sepsis is essential for better patient outcomes. However, conventional diagnostic methods, such as bacterial cultures, …

kr, us (code pays fourni par la source)

Extracellular vesicles derived from salivary gland stem cells cultured on microwell scaffolds loaded with WNT3A promote the recovery of salivary gland function damaged by radiation via the YWHAZ-PI3K-AKT pathway

Jae-Min Cho, Sujeong Ahn, Yeo‐Jun Yoon, Sunyoung Park et autres

Salivary gland (SG) stem cell-derived extracellular vesicles (EVs) are promising agents for regenerative therapy, but efficient production and targeted delivery remain key challenges. We developed a WNT3A-releasing double-layered microwell scaffold by integrating WNT3A-loaded poly(D,L-lactide-co-glycolide) (PLGA) nanofibers with a polycaprolactone (PCL)-based microwell array. …

kr (code pays fourni par la source)